Smart Medicine,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: Feb. 1, 2024
Abstract
Immune
engineering,
a
burgeoning
field
within
regenerative
medicine,
involves
spectrum
of
strategies
to
optimize
the
intricate
interplay
between
tissue
biomaterials
and
host
tissue.
These
are
applied
across
different
types
various
disease
models,
which
encompasses
finely
modulating
immune
response
at
levels
cells
factors,
aiming
mitigate
adverse
effects
like
fibrosis
persistent
inflammation
that
may
arise
injury
site
consequently
promote
regeneration.
With
continuous
progress
in
electrospinning
technology,
immunoregulatory
capabilities
electrospun
fibers
have
gained
substantial
attention
over
years.
Electrospun
fibers,
with
their
extracellular
matrix‐like
characteristics,
high
surface‐area‐to‐volume
ratio,
reliable
pharmaceutical
compound
capacity,
emerged
as
key
players
among
engineering
materials.
This
review
specifically
focuses
on
role
fiber‐based
emphasizing
unique
design
strategies.
Notably,
actively
engages
by
responses
through
four
essential
strategies:
(i)
surface
modification,
(ii)
drug
loading,
(iii)
physicochemical
parameters,
(iv)
biological
grafting.
presents
comprehensive
overview
mechanisms
system
injured
tissues
while
unveiling
adopted
orchestrate
regulation.
Furthermore,
explores
current
developmental
trends
limitations
concerning
function
drive
advancements
its
full
potential.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: June 22, 2024
Bioelectricity
provides
electrostimulation
to
regulate
cell/tissue
behaviors
and
functions.
In
the
human
body,
bioelectricity
can
be
generated
in
electromechanically
responsive
tissues
organs,
as
well
biomolecular
building
blocks
that
exhibit
piezoelectricity,
with
a
phenomenon
known
piezoelectric
effect.
Inspired
by
natural
bio-piezoelectric
phenomenon,
efforts
have
been
devoted
exploiting
high-performance
synthetic
biomaterials,
including
molecular
materials,
polymeric
ceramic
composite
materials.
Notably,
biomaterials
polarize
under
mechanical
strain
generate
electrical
potentials,
which
used
fabricate
electronic
devices.
Herein,
review
article
is
proposed
summarize
design
research
progress
of
devices
toward
bionanotechnology.
First,
functions
regulating
electrophysiological
activity
from
cellular
tissue
level
are
introduced.
Next,
recent
advances
structure-property
relationship
various
provided
detail.
following
part,
applications
engineering,
drug
delivery,
biosensing,
energy
harvesting,
catalysis
systematically
classified
discussed.
Finally,
challenges
future
prospects
presented.
It
believed
this
will
provide
inspiration
for
development
innovative
fields
biomedicine
nanotechnology.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(14)
Published: Jan. 10, 2024
Electrical
stimulation
(ES)
has
shown
beneficial
effects
in
repairing
injured
tissues.
However,
current
ES
techniques
that
use
tissue-traversing
leads
and
bulky
external
power
suppliers
have
significant
limitations
translational
medicine.
Hence,
exploring
noninvasive
vivo
to
provide
controllable
electrical
cues
tissue
engineering
is
an
imminent
necessity.
Herein,
a
conductive
hydrogel
with
situ
generation
capability
as
biodegradable
regeneration
scaffold
wireless
platform
for
spinal
cord
injury
(SCI)
repair
demonstrated.
When
soft
insulated
metal
plate
placed
on
top
of
the
site
transmitter,
implanted
at
can
serve
receiver,
capacitive
coupling
between
receiver
transmitter
generate
alternating
owing
electrostatic
induction
effect.
In
complete
transection
model
SCI
rats,
hydrogels
capacitive-coupling
enhance
functional
recovery
neural
by
promoting
remyelination,
accelerating
axon
regeneration,
facilitating
endogenous
stem
cell
differentiation.
This
facile
wireless-powered
electroactive-hydrogel
strategy
thus
offers
on-demand
adjustable
timeline,
duration,
strength
holds
great
promise
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(3), P. 1167 - 1315
Published: Jan. 1, 2024
Silicon-based
biomaterials
have
been
extensively
developed
in
the
past
decades.
The
classification,
characteristics,
multi-dimensional
design,
and
biomedical
applications
of
silicon-containing
are
comprehensively
elaborated.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 7, 2024
The
treatment
of
critical-size
bone
defects
with
irregular
shapes
remains
a
major
challenge
in
the
field
orthopedics.
Bone
implants
adaptability
to
complex
morphological
defects,
bone-adhesive
properties,
and
potent
osteogenic
capacity
are
necessary.
Here,
shape-adaptive,
highly
bone-adhesive,
ultrasound-powered
injectable
nanocomposite
hydrogel
is
developed
via
dynamic
covalent
crosslinking
amine-modified
piezoelectric
nanoparticles
biopolymer
networks
for
electrically
accelerated
healing.
Depending
on
inorganic-organic
interaction
between
amino-modified
bio-adhesive
network,
adhesive
strength
prepared
exhibited
an
approximately
3-fold
increase.
In
response
ultrasound
radiation,
could
generate
controllable
electrical
output
(-41.16
61.82
mV)
enhance
effect
vitro
vivo
significantly.
Rat
calvarial
defect
repair
validates
addition,
bioinformatics
analysis
reveals
that
ultrasound-responsive
enhanced
differentiation
mesenchymal
stem
cells
by
increasing
calcium
ion
influx
up-regulating
PI3K/AKT
MEK/ERK
signaling
pathways.
Overall,
present
work
novel
wireless
broadens
therapeutic
horizons
defects.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(17), P. 8632 - 8712
Published: Jan. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Abstract
Tissue
engineering
and
electrotherapy
are
two
promising
methods
to
promote
tissue
repair.
However,
their
integration
remains
an
underexplored
area,
because
requirements
on
devices
usually
distinct.
Triboelectric
nanogenerators
(TENGs)
have
shown
great
potential
develop
self‐powered
devices.
due
susceptibility
moisture,
TENGs
be
encapsulated
in
vivo.
Therefore,
existing
cannot
employed
as
scaffolds,
which
require
direct
interaction
with
surrounding
cells.
Here,
the
concept
of
triboelectric
scaffolds
(TESs)
is
proposed.
Poly(glycerol
sebacate),
a
biodegradable
relatively
hydrophobic
elastomer,
selected
matrix
TESs.
Each
micropore
multi‐hierarchical
porous
TESs
efficiently
serves
moisture‐resistant
working
unit
TENGs.
Integration
tons
micropores
ensures
ability
vivo
without
encapsulation.
Originally
degraded
by
surface
erosion
transformed
into
hydrophilic
surfaces,
facilitating
role
scaffolds.
Notably,
seeded
chondrocytes
obtain
dense
large
matured
cartilages
after
subcutaneous
implantation
nude
mice.
Importantly,
rabbits
osteochondral
defects
receiving
TES
show
favorable
hyaline
cartilage
regeneration
complete
healing.
This
work
provides
electronic
biomedical
device
will
inspire
series
new
applications.
Journal of Biomedical Materials Research Part A,
Journal Year:
2025,
Volume and Issue:
113(1)
Published: Jan. 1, 2025
ABSTRACT
In
the
human
body,
bioelectric
cues
are
crucial
for
tissue
stimulation
and
regeneration.
Electrical
(ES)
significantly
enhances
regeneration
of
nerves,
bones,
cardiovascular
tissues,
wounds.
However,
use
conventional
devices
with
stimulating
metal
electrodes
is
invasive
requires
external
batteries.
Consequently,
electrically
active
materials
excellent
biocompatibility
have
attracted
attention
their
applications
in
engineering.
To
fully
exploit
potential
these
materials,
biocompatibility,
operating
mechanisms,
electrical
properties,
even
biodegradability
should
be
carefully
considered.
this
review,
we
categorize
various
biomaterials
based
on
mechanisms
generating
cues,
such
as
piezoelectric
effect,
triboelectric
others.
We
also
summarize
key
material
including
characteristics
biodegradability,
describe
musculoskeletal
tissues.
The
hold
great
advancing
field
engineering
demonstrated
success
underscores
importance
continued
research
field.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
High‐tension
site
wounds
are
frequently
accompanied
by
challenges
associated
with
hypertrophic
scarring.
The
key
to
achieving
scar‐free
healing
is
the
creation
of
a
mechanical
environment
conducive
skin
regeneration.
Herein,
simple
rolling
punctures
utilized
on
angle
transform
molds
develop
cat
tongue
prick
bionic
angle‐adjustable
microneedles
(TPMNs)
maintain
firm
grip
periwound
skin,
thereby
reducing
tissue
tension.
integration
TPMNs
triboelectric
nanogenerators
(TENGs)
enables
excellent
conductive
and
properties.
system
can
provide
stable
spatial
electric
field
around
wound
promote
cell
migration.
As
microfluid
reaches
TPMNs,
self‐driving
force
enhanced
unique
design
control
flow
rate.
Sufficient
evidence
has
shown
that
expedite
contraction
regeneration
while
concurrently
scar
formation
in
mouse
trauma
model
experiments.
innovative
TPMNs‐TENGs
synergistically
provides
highly
functional
platform
for
tension
relief,
which
suitable
treatment
this
study
potentially
extends
construction
regulation
smart
wearable
devices.
