Recent advances in noble metal complex based photodynamic therapy

Chemical Science, Journal Year: 2022, Volume and Issue: 13(18), P. 5085 - 5106

Published: Jan. 1, 2022

This minireview summarizes recent developments of noble metal photosensitizers based on Ru, Ir, and Pt. Molecular design strategies to overcome shallow tissue penetration depth, O 2 -dependence the limited therapeutic effect are introduced.

Language: Английский

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Harnessing anti‐tumor and tumor‐tropism functions of macrophages via nanotechnology for tumor immunotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(3)

Published: Feb. 25, 2022

Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in immunotherapy. As a class of professional phagocytes and antigen-presenting cells innate immune system, can not only directly engulf clear cells, but also play roles presenting tumor-specific antigen to initiate adaptive immunity. However, tumor-associated (TAMs) usually display tumor-supportive M2 phenotype rather than anti-tumor M1 phenotype. They support escape immunological surveillance, aggravate progression, impede T cell Although many TAMs-modulating agents have shown success therapy multiple tumors, they face enormous challenges including poor accumulation off-target side effects. An alternative solution is use advanced nanostructures, which deliver augment therapeutic efficacy, serve as modulators TAMs. Another important strategy exploitation macrophage-derived components tumor-targeting delivery vehicles. Herein, we summarize recent advances targeting engineering for immunotherapy, (1) direct indirect effects on augmentation immunotherapy (2) strategies macrophage-based drug carriers. The existing perspectives immunotherapies are highlighted.

Language: Английский

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A Thrombin‐Activated Peptide‐Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 2, 2023

Ischemic stroke (IS) is one of the most common causes disability and death. Thrombolysis neuroprotection are two current major therapeutic strategies to overcome ischemic reperfusion damage. In this work, a novel peptide-templated manganese dioxide nanozyme (PNzyme/MnO

Language: Английский

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Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer

Cancer Nanotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 25, 2023

Abstract Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while efficacy still unsatisfactory and limited by unique immunosuppressive microenvironment site. Here, we developed a bone-targeted nano-delivery system as nano-regulator to enhance immunotherapy PCa. The nanosystem was assembled via coordination between phytic acid (PA) Fe 3+ form nano-sized metal–organic framework (MOF), through which mitoxantrone (MTO) encapsulated. At cellular level, showed selective cytotoxicity towards RM-1 cells over immune cells, could induce tumor immunogenic cell (ICD) improve immunogenicity tumor. Moreover, able ubiquitination TGFβ receptor (TβR) on promote its degradation, thus serving block functions TGF-β, an abundant cytokine that has systematically effect microenvironment. Upon intravenous injection, nanoparticle pro-longed blood circulation targeting accumulation into site, imposed robust anti-tumor combination αCTLA-4. In addition, destruction significantly alleviated after reduce skeletal-related events. Overall, this work provides biocompatible nanomedicine restore sensitivity enhanced blocking TGF-β signaling pathway.

Language: Английский

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Platinum Prodrug Nanoparticles with COX‐2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)

Published: Dec. 14, 2023

Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to trigger a robust antitumor immune response. Platinum-based chemotherapeutic agents can induce pyroptosis via caspase-3 activation. However, these also enhance cyclooxygenase-2 (COX-2) expression in tumor tissues, leading drug resistance and evasion pancreatic cancer significantly limiting the effectiveness chemotherapy-induced pyroptosis. Here, amphiphilic polymer (denoted as PHDT-Pt-In) containing both indomethacin (In, COX-2 inhibitor) platinum(IV) prodrug (Pt(IV)) is developed, which responsive glutathione (GSH). This self-assemble into nanoparticles Pt-In NP) that disintegrate cells due GSH responsiveness, releasing In inhibit expression, hence overcoming chemoresistance amplifying cisplatin-induced mouse model, NP growth elicit innate adaptive responses. Moreover, when combined with anti-programmed death ligand (α-PD-L1) treatment, demonstrate ability completely suppress metastatic tumors, transforming "cold tumors" "hot tumors". Overall, sustained release Pt(IV) from amplifies platinum-drug-induced long-term responses, presenting generalizable strategy for cancer.

Language: Английский

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Tumor microenvironment‐responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy

Exploration, Journal Year: 2023, Volume and Issue: 3(6)

Published: July 27, 2023

Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis and antitumor immune responses, which exhibits tremendous in treatment. However, the therapeutic efficacy of CO is inhibited by immunosuppressive tumor microenvironment (TME). Herein, a facile strategy proposed construct hollow-structured rough nanoplatforms boost immunity simultaneously reverse immunosuppression exploring intrinsic immunomodulatory properties morphological optimization nanomaterials. The TME-responsive delivery nanosystems (M-RMH) are developed encapsulating prodrug within hollow MnO

Language: Английский

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Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 25, 2024

Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based

Language: Английский

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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: June 9, 2024

Abstract The tumor microenvironment (TME) of typical types such as triple‐negative breast cancer is featured by hypoxia and immunosuppression with abundant tumor‐associated macrophages (TAMs), which also emerge potential therapeutic targets for antitumor therapy. M1‐like macrophage‐derived exosomes (M1‐Exos) have emerged a promising candidate their tumor‐targeting macrophage‐polarization capabilities. However, the limited drug‐loading efficiency stability M1‐Exos hindered effectiveness in applications. Here, hybrid nanovesicle developed integrating AS1411 aptamer‐conjugated liposomes (AApt‐Lips), termed M1E/AALs. obtained M1E/AALs are loaded perfluorotributylamine (PFTBA) IR780, P‐I, to construct P‐I@M1E/AALs reprogramming TME alleviating engineering TAMs. P‐I@M1E/AAL‐mediated therapy enhances situ generation reactive oxygen species, repolarizes TAMs toward an phenotype, promotes infiltration T lymphocytes. synergistic based on significantly suppresses growth prolongs survival 4T1‐tumor‐bearing mice. By multiple treatment modalities, P‐I@M1E/AAL nanoplatform demonstrates approach overcoming hypoxic immunosuppressive targeted TAM enhanced photodynamic immunotherapy. This study highlights innovative TAM‐engineering platform tumors characterized TME.

Language: Английский

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Deformable nanocarriers for enhanced drug delivery and cancer therapy

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 15, 2024

Abstract Recently, the field of nanomedicine has witnessed substantial advancements in development nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable have garnered considerable attention due their unique capabilities size changeable, tumor‐specific aggregation, stimuli‐triggered disintegration, morphological transformations. These present significant opportunities revolutionizing delivery strategies, by responding specific stimuli or environmental cues, enabling achieved various functions at tumor site, including size‐shrinkage penetration, aggregative retention effect, disintegrating enable controlled release, shape‐changing improve cellular uptake, allowing personalized treatment approaches combination therapies. This review provides an overview recent developments applications enhancing therapy, underscores diverse design strategies employed create elucidates remarkable potential therapy.

Language: Английский

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A pH-Responsive and Guanidinium-Rich Nanoadjuvant Efficiently Delivers STING Agonist for Cancer Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

As natural agonists of the stimulator interferon genes (STING), cyclic dinucleotides (CDNs) have been identified as promising immunotherapies that trigger a potent immune response against tumors. However, low stability, rapid clearance, inadequate cellular uptake, and inefficient cytosol localization heavily hinder therapeutic efficacy hydrophilic negatively charged 2′, 3′-cyclic-GMP-AMP (cGAMP). How to efficiently deliver cGAMP into endoplasmic reticulum (ER) activate STING for priming remains challenging. Here, we report pH-responsive guanidinium-rich nanoagonist (nPGSA) delivery cGAMP. Compared with free cGAMP, nPGSA achieves up 37.4-fold enhancement internalization. The pH-sensitive guanidinium-functional design facilitates quick release endosome escape, thus enabling precise ER targeting 33.9-fold amplification sensibilization. Furthermore, through modulation tumor-associated macrophage (TAM) polarization, elicits antigen-specific sustained tumor regression in melanoma- neuroblastoma-bearing mice. Our study provides strategy it offers insights function modulating microenvironment cancer immunotherapy.

Language: Английский

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