Multifunctional Biosensing In Vivo with Optical Manipulation DOI Creative Commons
Xiaoshuai Liu, Yanzheng Xie

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

The multifunctional biosensing at specific positions, without destroying the epidermal tissue, is of great importance for early diagnosis and accurate therapy cardiovascular disease cancer. Conventional detection techniques are usually based on needle-type microelectrode molecular imaging in situ quantitative characterization vivo. However, due to characteristics direct contact invasive implantation, it easy cause large tissue trauma organisms as well a series postoperative complications. Therefore, an vivo technique needs be developed that not only allows active control fluorescent probes but also enables noninvasive sub-micrometer resolution. In this chapter, we will introduce emerging strategy by organic integration optical manipulation technique, which fully nanoprobe noninvasively multipoint Moreover, reported could achieve overexpression heterogenous distribution biomarkers thrombus even extend perform desired removal highly programmable selective manner.

Language: Английский

Tumor microenvironment‐responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy DOI Creative Commons
Beibei Chen,

Kangli Guo,

Xiaoyi Zhao

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(6)

Published: July 27, 2023

Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis and antitumor immune responses, which exhibits tremendous in treatment. However, the therapeutic efficacy of CO is inhibited by immunosuppressive tumor microenvironment (TME). Herein, a facile strategy proposed construct hollow-structured rough nanoplatforms boost immunity simultaneously reverse immunosuppression exploring intrinsic immunomodulatory properties morphological optimization nanomaterials. The TME-responsive delivery nanosystems (M-RMH) are developed encapsulating prodrug within hollow MnO

Language: Английский

Citations

62
Platinum Prodrug Nanoparticles with COX‐2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer DOI

Bingzheng Yu,

Yushu Wang,

Tiejun Bing

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)

Published: Dec. 14, 2023

Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to trigger a robust antitumor immune response. Platinum-based chemotherapeutic agents can induce pyroptosis via caspase-3 activation. However, these also enhance cyclooxygenase-2 (COX-2) expression in tumor tissues, leading drug resistance and evasion pancreatic cancer significantly limiting the effectiveness chemotherapy-induced pyroptosis. Here, amphiphilic polymer (denoted as PHDT-Pt-In) containing both indomethacin (In, COX-2 inhibitor) platinum(IV) prodrug (Pt(IV)) is developed, which responsive glutathione (GSH). This self-assemble into nanoparticles Pt-In NP) that disintegrate cells due GSH responsiveness, releasing In inhibit expression, hence overcoming chemoresistance amplifying cisplatin-induced mouse model, NP growth elicit innate adaptive responses. Moreover, when combined with anti-programmed death ligand (α-PD-L1) treatment, demonstrate ability completely suppress metastatic tumors, transforming "cold tumors" "hot tumors". Overall, sustained release Pt(IV) from amplifies platinum-drug-induced long-term responses, presenting generalizable strategy for cancer.

Language: Английский

Citations

62
Surface Oxygen Vacancies and Corona Polarization of Bi4Ti3O12 Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy DOI
Jie Ma, Meng Yuan, Zhuang Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(32), P. 22348 - 22359

Published: Aug. 1, 2024

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.

Language: Английский

Citations

24
Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma DOI

Shaoping Jiang,

Wenpei Li,

Jun Yang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6445 - 6462

Published: Feb. 15, 2024

Tumor-associated macrophages (TAMs) are closely related to the progression of glioblastoma multiform (GBM) and its development therapeutic resistance conventional chemotherapy. TAM-targeted therapy combined with chemotherapy has emerged as a promising strategy combat GBM. However, presence blood–brain barrier (BBB) severely limits efficacy. Meanwhile, lack ability distinguish different targeted cells also poses challenge for precise therapy. Herein, we propose cathepsin B (CTSB)-responsive programmed brain-targeted delivery system (D&R-HM-MCA) simultaneous GBM-targeted delivery. D&R-HM-MCA could cross BBB via low density lipoprotein receptor-associated protein 1 (LRP1)-mediated transcytosis. Upon reaching GBM site, outer angiopep-2 modification be detached from cleavage CTSB-responsive peptide, which circumvent abluminal LRP1-mediated efflux. The exposed p-aminophenyl-α-d-mannopyranoside (MAN) further recognize glucose transporter-1 (GLUT1) on macrophage mannose receptor (MMR) TAMs. achieve chemotherapeutic killing simultaneously induce TAM polarization anti-inflammatory M2 phenotype pro-inflammatory M1 phenotype, thus resensitizing response improving anti-GBM immune response. This not only can improve brain efficiency, but enable combination chemo-immunotherapy against effectiveness this may provide thinking designing more functional systems effective regimens.

Language: Английский

Citations

22
Basic helix–loop–helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases DOI Creative Commons
Fanglin Shao, Zhipeng Wang,

Luxia Ye

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

The circadian clock is an internal timekeeper system that regulates biological processes through a central and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein (ARNTL1), key component of the clock. deletion BMAL1 alone can abolish rhythms human body. plays critical role in immune cell function. Dysregulation linked to immune-related diseases such autoimmune diseases, infectious cancer, vice versa. This review highlights significant governing cells, including their development, differentiation, migration, homing, metabolism, effector functions. study explores how dysregulation have far-reaching implications potentially contribute onset sepsis, trauma. Furthermore, this discusses treatments for target disorders. Understanding impact on function provide insights into pathogenesis help development more effective treatment strategies. Targeting has been demonstrated achieve good efficacy indicating its promising potential targetable therapeutic these diseases.

Language: Английский

Citations

4
Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors DOI Creative Commons
Hang Li,

Yunheng Liu,

Xiaokang Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared mono-treatment regimens. However, its use is associated drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, immunotherapy for tumor treatment. These nanoparticles (D/I@HST NPs) accurately target overexpressed transferrin receptors (TfRs) on the surface of cells surface-modified (Tf). After endocytosis, D/I@HST NPs generate ROS under 808-nm laser irradiation, breaking ROS-responsive crosslinking agent increasing drug release utilization. Tf also carries Fe3+, reduced to Fe2+ by iron reductase in acidic microenvironment (TME). Consequently, endoperoxide bridge structure dihydroartemisinin cleaved, causing additional generation. Furthermore, released IR-780 exerts both photodynamic photothermal effects, enhancing cell death. This multi-pathway amplification effect can trigger immunogenic death tumors, promoting relevant antigens damage-associated molecular patterns, thereby dendritic maturation sensitivity immunotherapy. Mature transmit signals T cells, infiltration activation, facilitating growth inhibition suppression lung metastasis. myeloid-derived suppressor decreases after In summary, this stress-amplified effectively inhibits reverses immunosuppressive microenvironment, provides new insights into combined phototherapy.

Language: Английский

Citations

3
Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition DOI

Wuyang Wei,

Hai Wang,

Ren Chunrong

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 3, 2024

Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form inflammatory programmed cell death, presents dependable strategy combating cancer by engaging multiple death pathways (apoptosis, pyroptosis, necroptosis). In this study, ultrasmall Bi 2 Sn O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties designed engineered as PANoptosis inducer through destroying mitochondrial function tumor cells enhancing intracellular accumulation toxic reactive oxygen species, finally triggering activation process. The role has been verified expression related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, 1, p‐MLKL, RIPK3. inclusion external ultrasonic irradiation significantly augments enzyodynamic efficiency. vitro in vivo antineoplastic efficacy, along inhibition lung metastasis, validate benefits ‐mediated pathway. This study not only elucidates intricate mechanisms underlying inducer, but also offers novel perspective treatment carcinoma.

Language: Английский

Citations

18
Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy DOI

Qiuhong Ouyang,

Ying Zhao, Kunyao Xu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

Citations

16
Recent development of micro-nano carriers for oral antineoplastic drug delivery DOI Creative Commons
Hongzheng Li, Xiang Chen,

Shangrui Rao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101445 - 101445

Published: Jan. 5, 2025

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.

Language: Английский

Citations

2
Cascade Reactions Catalyzed by Gold Hybrid Nanoparticles Generate CO Gas Against Periodontitis in Diabetes DOI Creative Commons

Yi Wang,

Tengda Chu,

Ting Jin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)

Published: April 22, 2024

Abstract The treatment of diabetic periodontitis poses a significant challenge due to the presence local inflammation characterized by excessive glucose concentration, bacterial infection, and high oxidative stress. Herein, mesoporous silica nanoparticles (MSN) are embellished with gold (Au NPs) loaded manganese carbonyl prepare carbon monoxide (CO) enhanced multienzyme cooperative hybrid nanoplatform (MSN‐Au@CO). Glucose‐like oxidase activity Au NPs catalyzes oxidation hydrogen peroxide (H 2 O ) gluconic acid，and then converts H hydroxyl radicals (•OH) peroxidase‐like destroy bacteria. Moreover, CO production in response , together exhibited synergistic anti‐inflammatory effect macrophages challenged lipopolysaccharides. underlying mechanism can be induction nuclear factor erythroid 2‐related reduce reactive oxygen species, inhibition kappa‐B signaling diminish inflammatory response. Importantly, antibacterial anti‐inflammation effects MSN‐Au@CO validated rats ligature‐induced showing decreased periodontal bone loss good biocompatibility. To summarize, is fabricate utilize glucose‐activated cascade reaction eliminate bacteria, synergize gas therapy regulate immune microenvironment, offering potential direction for periodontitis.

Language: Английский

Citations

9