Journal of Traditional Chinese Medical Sciences,
Journal Year:
2024,
Volume and Issue:
11(3), P. 340 - 350
Published: June 5, 2024
To
determine
the
main
components
of
Astragalus
membranaceus
(Fisch.)
Bge.
(A.
membranaceus,
Huang
Qi),
Astragaloside
IV
(AIV)
and
polysaccharides
(AP),
to
characterize
their
properties,
evaluate
in
vivo
efficacy,
analyze
drug
diffusion
using
dissolving
microneedle
(DMN)
technology
vivo.
Respectively,
AIV-
AP-loaded
DMNs
comprising
chitosan
(CTS)
polyvinyl
alcohol
(PVA)
were
prepared
via
dual-mold
forming.
Their
morphology,
mechanical
solubility,
skin
irritation
characteristics
tested.
In
efficacy
was
assessed
cyclophosphamide-induced
immunosuppressed
mice,
AIV
AP
by
conventional
methods
compared,
rheological
properties
AIV-CTS-PVA
AP-CTS-PVA
mixtures
measured.
Subcutaneous
dissolution
absorption
microneedles
(MNs)
at
low
doses
(50%
–
17%
intraperitoneal
injection
12%
4%
intravenous
injection)
reduced
spleen
index
acid
phosphatase
activity
mouse
models,
increased
thymus
index,
achieved
equivalent
or
better
systemic
therapeutic
effects.
Compared
with
injections,
controllable
solid-liquid
conversion
through
delivery
CTS-PVA
MNs,
resulting
highly
localized
aggregation
within
48
h,
reducing
initial
explosive
effect
drug,
achieving
stable
slow
release.
The
present
study
enhances
our
understanding
remote
effects
drug-loaded
from
a
traditional
Chinese
medicine
(TCM)
perspective,
thereby
promoting
development
precise
efficient
TCM
further
expanding
drug-loading
range
application
scenarios
for
DMNs.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100184 - 100184
Published: June 26, 2024
Polyphenol
is
a
versatile
green
phytochemical
vital
in
several
biomedical
applications
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
emergence
of
novel
nanotechnology
techniques,
such
as
electrospinning,
has
proven
to
be
an
excellent
option
for
nanotechnology,
ensuring
effective
drug
delivery
system
recognised
medicinal
plant
extracts
containing
polyphenols
electrospun
nanofibers
can
provide
the
necessary
environment
encapsulation.
Together,
have
shown
promising
usage
wound
healing.
When
are
incorporated
into
nanofibrous
scaffolds,
their
combined
properties
enhance
cell
attachment,
proliferation,
differentiation.
This
review
explores
potential
polyphenol-loaded
therapy,
highlighting
importance
efficient
systems
polyphenols.
It
provides
brief
assessment
specific
(resveratrol,
curcumin,
thymol,
quercetin,
tannic
acid,
ferulic
hesperidin,
gallic
kaempferol,
chlorogenic
acid)
that
been
successfully
encapsulated
applied
treatment.
Despite
ongoing
research,
certain
carvacrol,
oleuropein,
kaempferol
remain
less
explored.
underscores
need
continued
investigation
these
while
recognising
growing
application
healing
more
extensive
therapeutic
use.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1559 - 1572
Published: May 9, 2024
Three-Dimensional
(3D)
microneedles
have
recently
gained
significant
attention
due
to
their
versatility,
biocompatibility,
enhanced
permeation,
and
predictable
behavior.
The
incorporation
of
biological
agents
into
these
3D
constructs
has
advanced
the
traditional
microneedle
an
effective
platform
for
wide-ranging
applications.
Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Microneedles
(MNs)
have
emerged
as
a
promising
transdermal
antimicrobial
delivery
system,
providing
precise
and
localized
drug
while
complemented
with
noninvasiveness
patient
compliance.
Currently,
the
topical
application
of
antimicrobials
restricts
drugs
to
critical
areas
wound
bed,
largely
due
barriers
posed
by
necrotic
tissue,
scab
formation,
bacterial
biofilms,
which
severely
diminish
bioavailability
therapeutics.
MNs
enabled
efficient
targeted
overcome
many
chronic
challenges.
Over
past
decade,
significant
progress
has
been
made
develop
unique
properties
tailored
for
vaccines,
anticancer,
antimicrobials.
As
ongoing
research
continues
refine
MN
design,
material
properties,
formulations,
potential
revolutionizing
efficacy,
experience,
therapeutic
outcomes
remains
at
forefront
scientific
research.
In
this
review,
insights
are
provided
into
latest
progress,
current
developments,
diverse
applications
delivery.
Herein,
translational
is
highlighted
perspective
on
challenges
associated
clinical
translation
provided.
Furthermore,
review
aids
in
identifying
gaps
empowering
contributing
future
implementation
cutting‐edge
systems
effectively
tackle
resistance.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 4321 - 4337
Published: May 1, 2024
Cannabidiol
(CBD)
is
a
promising
therapeutic
drug
with
low
addictive
potential
and
favorable
safety
profile.
However,
CBD
did
face
certain
challenges,
including
poor
solubility
in
water
oral
bioavailability.
To
harness
the
of
by
combining
it
transdermal
delivery
system
(TDDS).
This
innovative
approach
sought
to
develop
patch
dosage
form
micellar
vesicular
nanocarriers
enhance
bioavailability
CBD,
leading
improved
outcomes.
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 1, 2025
The
process
of
wound
healing
is
frequently
impeded
by
metabolic
imbalances
within
the
microenvironment.
MXenes
exhibit
exceptional
biocompatibility,
biodegradability,
photothermal
conversion
efficiency,
conductivity,
and
adaptable
surface
functionalization,
demonstrating
marked
potential
in
development
multifunctional
platforms
for
healing.
Moreover,
integration
with
other
bioactive
nanomaterials
has
been
shown
to
enhance
their
therapeutic
efficacy,
paving
way
innovative
approaches
In
this
review,
we
provide
a
systematic
exposition
mechanisms
through
which
facilitate
offer
comprehensive
analysis
current
research
landscape
on
MXene-based
composites
field.
By
delving
into
latest
scientific
discoveries,
identify
existing
challenges
future
trajectories
advancement
MXenes.
Our
evaluation
aims
insightful
guidance
formulation
more
effective
strategies.
