Recent development of pH‐responsive theranostic nanoplatforms for magnetic resonance imaging‐guided cancer therapy

Exploration, Journal Year: 2023, Volume and Issue: 3(3)

Published: March 30, 2023

The acidic characteristic of the tumor site is one most well-known features and provides a series opportunities for cancer-specific theranostic strategies. In this regard, pH-responsive nanoplatforms that integrate diagnostic therapeutic capabilities are highly developed. fluidity microenvironment (TME), with its temporal spatial heterogeneities, makes noninvasive molecular magnetic resonance imaging (MRI) technology very desirable TME constituents developing MRI-guided tumor-specific treatments. Therefore, various MRI-based strategies which employ assorted modes have been drawn up more efficient cancer therapy through raised local concentration agents in pathological tissues. review, we summarize mechanisms organic components (including polymers, biological molecules, organosilicas) as well inorganic metal coordination compounds, oxides, salts) nanoplatforms. Furthermore, review designs applications diagnosis treatment cancer. addition, challenges prospects pH-responsiveness discussed.

Language: Английский

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A Giant Heterometallic Polyoxometalate Nanocluster for Enhanced Brain‐Targeted Glioma Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(10)

Published: Jan. 10, 2024

Giant heterometallic polyoxometalate (POM) clusters with precise atom structures, flexibly adjustable and abundant active sites are promising for constructing functional nanodrugs. However, current POM drugs almost vacant in orthotopic brain tumor therapy due to the inability effectively penetrate blood-brain barrier (BBB) low drug activity. Here, we designed largest (3.0 nm × 6.0 nm) transition-metal-lanthanide co-encapsulated cluster {[Ce

Language: Английский

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pH-responsive membranes: Mechanisms, fabrications, and applications

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 173865 - 173865

Published: June 14, 2024

Language: Английский

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Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(12), P. 9100 - 9113

Published: March 13, 2024

Reactive oxygen species (ROS) mediated tumor cell death is a powerful anticancer strategy. Cuproptosis copper-dependent and ROS-mediated prospective therapy However, the complex microenvironment (TME), low specificity, poor efficiency, lack of imaging capability impair output current cuproptosis drugs. Herein, we designed dual-responsive two-dimensional metal–organic framework (2D MOF) nanotheranostic via coordination self-assembly strategy using Au(III) tetra-(4-pyridyl) porphine (AuTPyP) as ligand copper ions (Cu2+) nodes. The dual-stimulus combined with protonation pyridyl group in AuTPyP deep-penetration ultrasound (US) together triggered controlled release an acidic TME. ultrathin structure (3.0 nm) nanotheranostics promoted process. released Cu2+ was reduced to Cu+ by depleting overexpressed glutathione (GSH) tumor, which not only activated Ferredoxin 1 (FDX1)-mediated but also catalyzed hydrogen peroxide (H2O2) into reactive Fenton-like reaction. Simultaneously, could specifically bind thioredoxin reductase activate redox imbalance cells. These selectively induced significant mitochondrial vacuoles prominent did damage normal fluorescence magnetic resonance (MRI) results verified this target HeLa greatly promote self-enhanced effect chemotherapy/cuproptosis inhibition efficiency. work helped elucidate assembly multiresponsive high-specificity ROS regulation for application therapy.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

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Smart hydrogel: A new platform for cancer therapy

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470

Published: March 7, 2025

Language: Английский

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Cancer Stem‐Like Cells‐Oriented Surface Self‐Assembly to Conquer Radioresistance

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 8, 2023

Abstract Cancer stem‐like cells (CSCs), capable of indefinite self‐renewal and differentiation, are considered to be the root cause tumor radiotherapy (RT) resistance. However, CSCs‐targeted therapy still remains a great challenge because they commonly located in deep making drugs hard approach, their hypoxic acidic niche can further aggravate radioresistance. Herein, based on finding that CSCs highly express carbonic anhydrase IX (CAIX) cell membrane, CAIX‐targeted induced situ self‐assembly system surface CSC is reported overcome CSC‐mediated Via sequential processes “monomer release‐target accumulation‐surface self‐assembly”, constructed peptide‐based drug delivery (CA‐Pt) exhibits advantages penetration, amplified CAIX inhibition, enhanced cellular uptake, which greatly relieves microenvironment promote differentiation combines with platinum boost RT‐inducing DNA damage. In both lung cancer mouse zebrafish embryo models, CA‐Pt treatment effectively assist RT suppressing growth preventing invasion metastasis. This study uses surface‐induced strategy differentiate CSCs, may provide universal for overcoming

Language: Английский

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Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”

Exploration, Journal Year: 2023, Volume and Issue: 3(6)

Published: Oct. 28, 2023

Although the extraordinary progress has been made in molecular biology, prevention of cancer remains arduous. Most solid tumours exhibit both spatial and temporal heterogeneity, which is difficult to be mimicked vitro. Additionally, complex biochemical immune features tumour microenvironment significantly affect development. Molecular imaging aims at exploitation tumour-associated molecules as specific targets customized probe, thereby generating image contrast markers, offering opportunities non-invasively evaluate pathological characteristics vivo. Particularly, there are no "standard markers" control clinical diagnosis individuals, so characteristics-responsive nanoprobe-based quantitative imaging, able visualize determine accurate content values heterogeneous distribution tumours, can provide criteria for diagnosis. In this context, a variety "smart" nanoprobes have designed, order feasible approaches quantitatively This review summarizes recent achievements designs these nanoprobes, highlights state-of-the-art technologies molecules.

Language: Английский

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Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1079 - 1114

Published: Jan. 1, 2024

Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,

Language: Английский

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