Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 326 - 326
Published: March 3, 2025
Exosomes,
spherical
lipid-bilayered
particles
secreted
by
cells,
have
recently
emerged
as
a
novel
and
highly
promising
drug
delivery
system,
attracting
extensive
attention
in
the
field
of
biomedical
research.
Dendritic-cell-derived
exosomes
(DC-Exos)
possess
surface
protein
ligands
characteristic
DC
such
functional
MHC-I
MHC-II,
CD80,
CD86.
These
components
play
crucial
role
immune
responses,
facilitating
antigen
uptake,
presentation,
activation
antigen-specific
CD4
CD8
T
cells.
properties
make
them
striking
excellent
vehicles
for
use
various
diseases
cancer
therapy.
This
review
summarizes
discusses
characteristics,
current
methods
types
loading
DC-Exos.
Its
modifications
application
disease
treatment
were
also
discussed,
aiming
to
motivate
development
exosome-based
theranostic
nanoplatforms
nanotechnology
improved
healthcare
treatments.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(30)
Published: June 14, 2024
Abstract
In
recent
decades,
research
on
Extracellular
Vesicles
(EVs)
has
gained
prominence
in
the
life
sciences
due
to
their
critical
roles
both
health
and
disease
states,
offering
promising
applications
diagnosis,
drug
delivery,
therapy.
However,
inherent
heterogeneity
complex
origins
pose
significant
challenges
preparation,
analysis,
subsequent
clinical
application.
This
review
is
structured
provide
an
overview
of
biogenesis,
composition,
various
sources
EVs,
thereby
laying
groundwork
for
a
detailed
discussion
contemporary
techniques
preparation
analysis.
Particular
focus
given
state‐of‐the‐art
technologies
that
employ
microfluidic
non‐microfluidic
platforms
EV
processing.
Furthermore,
this
discourse
extends
into
innovative
approaches
incorporate
artificial
intelligence
cutting‐edge
electrochemical
sensors,
with
particular
emphasis
single
proposes
current
outlines
prospective
avenues
future
research.
The
objective
motivate
researchers
innovate
expand
methods
analysis
fully
unlocking
biomedical
potential.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 709 - 709
Published: May 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(46), P. 43374 - 43387
Published: Nov. 9, 2023
Exosomes
are
nanoscale
vesicles
secreted
by
living
cells
that
have
similar
membrane
composition
to
parental
and
carry
a
variety
of
proteins,
lipids,
nucleic
acids.
Therefore,
exosomes
certain
biological
activities
play
an
important
role
in
intercellular
communication.
On
the
basis
its
potential
as
carrier
for
drug
delivery
systems,
been
engineered
compensate
shortage
natural
through
various
engineering
strategies
improving
efficiency,
enhancing
targeting
tissues
organs,
extending
circulating
half-life
exosomes.
This
review
focuses
on
loading
drugs
different
strategies,
discussions
exosome
surface
modification
summarizes
advantages
disadvantages
strategies.
In
addition,
this
provides
overview
recent
applications
number
refractory
relapsable
diseases.
has
provide
reference
further
research
development
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 674 - 674
Published: May 16, 2024
The
escalating
demand
for
enhanced
therapeutic
efficacy
and
reduced
adverse
effects
in
the
pharmaceutical
domain
has
catalyzed
a
new
frontier
of
innovation
research
field
pharmacy:
novel
drug
delivery
systems.
These
systems
are
designed
to
address
limitations
conventional
administration,
such
as
abbreviated
half-life,
inadequate
targeting,
low
solubility,
bioavailability.
As
disciplines
pharmacy,
materials
science,
biomedicine
continue
advance
converge,
development
efficient
safe
systems,
including
biopharmaceutical
formulations,
garnered
significant
attention
both
domestically
internationally.
This
article
presents
an
overview
latest
advancements
categorized
into
four
primary
areas:
carrier-based
coupling-based
targeted
intelligent
devices,
based
on
their
main
objectives
methodologies.
Additionally,
it
critically
analyzes
technological
bottlenecks,
current
challenges,
future
trends
application
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(1), P. 45 - 70
Published: Jan. 2, 2024
Introduction
Exosomes,
a
type
of
extracellular
vesicles,
are
effective
tools
for
delivering
small-molecule
drugs
and
biological
therapeutics
into
cells
tissues.
Surface
modifications
with
targeting
ligands
ensure
precise
delivery
to
specific
cells,
minimizing
accumulation
in
healthy
organs
reducing
the
side
effects.
This
is
rapidly
growing
area
drug
research
this
review
aims
comprehensively
discuss
recent
advances
field.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
As
we
progress
into
the
21st
century,
cancer
stands
as
one
of
most
dreaded
diseases.
With
approximately
in
every
four
individuals
facing
a
lifetime
risk
developing
cancer,
remains
serious
health
challenges
worldwide.
Its
multifaceted
nature
makes
it
an
arduous
and
tricky
problem
to
diagnose
treat.
Over
years,
researchers
have
explored
plenty
approaches
avenues
improve
management.
One
notable
strategy
includes
study
extracellular
vesicles
(EVs)
potential
biomarkers
therapeutics.
Among
these
EVs,
exosomes
emerged
particularly
promising
candidates
due
their
unique
characteristic
properties
functions.
They
are
small
membrane-bound
secreted
by
cells
carrying
cargo
biomolecules
such
proteins,
nucleic
acids,
lipids.
These
play
crucial
roles
intercellular
communication,
facilitating
transfer
biological
information
between
cell-to-cell
communication.
Exosomes
transport
cargoes
DNA,
RNA,
lipids
involved
cellular
reprogramming
promoting
cancer.
In
this
review,
explore
molecular
composition
exosomes,
significance
chemistry
development,
its
theranostic
application
well
research
complications
solutions.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 3175 - 3199
Published: March 1, 2025
Extracellular
vesicles
(EVs)
participate
in
intercellular
communication
and
play
an
essential
role
physiological
pathological
processes.
In
recent
years,
EVs
have
garnered
significant
attention
as
cell-free
therapeutic
alternatives,
vectors
for
drug
gene
delivery,
biomarkers
disease
diagnosis
prognosis,
vaccine
development,
nutraceuticals.
The
biodistribution
of
critically
influences
their
efficacy
toxicity.
Therefore,
this
review
aims
to
discuss
the
main
factors
influencing
unmodified
EVs,
highlighting
distribution
patterns,
advantages,
limitations,
applications
under
different
routes
administration.
addition,
we
provide
a
comprehensive
discussion
currently
available
sources
summarize
current
status
potentials
EVs.
By
optimizing
administration
selecting
appropriate
EV
sources,
aim
offer
valuable
insights
enhance
delivery
efficiency
target
tissues.
