Chemical, Insecticidal, Antioxidant and Phytochemical Assessment of Thorn Apple (Datura metel L.) leaf extract from Pakistan's Subtropical Climate DOI Creative Commons
Abdul Mateen, Ansar Javeed, Adnan Arshad

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Datura metel L., a plant belonging to the solanaceae family, is renowned for its medicinal, agrochemical and poisonous properties. This research assessed chemical makeup, antioxidant properties, phytochemical content of D. metel leaf extracts by employing different solvents: ethanol (EtOH), ethyl acetate (EA), dichloromethane (DCM), n-hexane (n-Hx), distilled water (DW). Chemical profile was Gas Chromatography-Mass Spectrometry (GC-MS) assay whereas; activity determined using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay. While, Insecticidal against Brevicoryne brassicae evaluated via aphid dip method. On other hand, quantitative qualitative analysis carried out Folin–Ciocalteu reagent method aluminum chloride colorimetric method, respectively. GC-MS identified four major compounds as: 11H-Pyrido [3’,2’:4,5] imidazo [2,1-b] [1,3] benzothiazin-11-one (29.76%), 1,3-dimethyl Benzene (18.35%), Didodecyl phthalate (11.73%), 1,3,5-Trimethylbenzene (10.09%), along with six minor compounds. Qualitative extract discovered alkaloids, flavonoids, phenols, glycosides, substances. Whereas, tests revealed high concentration phenols (75.03 GAEg− 1) in increased levels flavonoids (99.33 QEg− 1). All samples showed significant DPPH inhibition ranging from 63.91–81.59%. Similarly, displayed mortality 81.66% 73.33% at 48 h exposure 200 mgmL− 1 assay, These findings underline potential utilizing leaves as valuable source bioactive medicinal advantages.

Language: Английский

Phytobioactive compounds as therapeutic agents for human diseases: A review DOI Creative Commons
Muhammad Riaz,

Ramsha Khalid,

Muhammad Afzal

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(6), P. 2500 - 2529

Published: April 17, 2023

Phytobioactive compounds are plant secondary metabolites and bioactive abundantly present in medicinal plants have remarkable therapeutic potential. Oxidative stress antibiotic resistance major causes of present-day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, inflammation. The data for this review were collected from Google Scholar, PubMed, Directory Open Access Journals (DOAJ), Science Direct by using keywords: "Medicinal plants, compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies reported the pharmacological potential phytobioactives. alkaloids, terpenes, polysaccharides isolated showed antioxidant, anticancer, cytotoxic, anti-inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, antidiabetic activities. This literature was planned to provide comprehensive insight into biopharmacological phytobioactive compounds. techniques used extraction isolation bioassays required their biological activities antimicrobial, cytotoxic activities, been discussed. Characterization structural elucidation HPLC, TLC, FTIR, GC-MS/MS, NMR also concludes that may be alternative synthetic agents treatment various diseases.

Language: Английский

Citations

110
Exploring the Safety, Efficacy, and Bioactivity of Herbal Medicines: Bridging Traditional Wisdom and Modern Science in Healthcare DOI Creative Commons
Acharya Balkrishna, Nidhi Sharma, Deepika Srivastava

et al.

Future Integrative Medicine, Journal Year: 2024, Volume and Issue: 3(1), P. 35 - 49

Published: March 25, 2024

This review explores the convergence of traditional wisdom and modern science in realm herbal medicines, focusing on safety, efficacy, bioactivity these natural remedies contemporary healthcare. The rich history deeply embedded cultural traditions, is witnessing a resurgence as quest for holistic personalized healthcare gains momentum. Herbal medicine, time-honored practice passed down through generations, experiencing renewed interest amid growing acknowledgment its potential benefits. delves into safety profiles remedies, subjecting them to rigorous scientific scrutiny. Additionally, it investigates efficacy interventions, aiming bridge gap between historical anecdotes empirical research. complex compounds, often containing numerous active ingredients, focal point, unraveling mechanisms which substances interact with human body. In world where synthesis holds promise advancing healthcare, this contributes ongoing dialogue. By critically examining aims illuminate evolving landscape medicine. goal integrate best both worlds enhance global well-being, acknowledging medicine valuable complement practices.

Language: Английский

Citations

23
Paclitaxel and its semi-synthetic derivatives: comprehensive insights into chemical structure, mechanisms of action, and anticancer properties DOI Creative Commons

Priyanka Sati,

Eshita Sharma, Praveen Dhyani

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 30, 2024

Abstract Cancer is a disease that can cause abnormal cell growth and spread throughout the body. It among most significant causes of death worldwide, resulting in approx. 10 million deaths annually. Many synthetic anticancer drugs are available, but they often come with side effects interact negatively other medications. Additionally, many chemotherapy used for cancer treatment develop resistance harm normal cells, leading to dose-limiting effects. As result, finding effective treatments developing new remains challenge. However, plants potent source natural products potential treatment. These biologically active compounds may be basis enhanced or less toxic derivatives. Herbal medicines/phytomedicines, plant-based drugs, becoming more popular treating complicated diseases like due their effectiveness particularly attractive option affordability, availability, lack serious They have broad applicability therapeutic efficacy, which has spurred scientific research into as agents. This review focuses on Paclitaxel (PTX), drug derived from Taxus sp., its ability treat specific tumors. PTX derivatives against various lines. Researchers use this detailed information affordable cancer.

Language: Английский

Citations

18
Exploring the Anti-Colon Cancer Potential of Polygonum minus: Integrating In Vitro and In Silico Studies DOI
Zhongming Yang, Zhongguo Yang,

Md Zuki Abu Bakar

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105853 - 105853

Published: Jan. 6, 2025

Language: Английский

Citations

3
Optimizing the production and efficacy of antimicrobial bioactive compounds from Streptomyces kanamyceticus in combating multi-drug-resistant pathogens DOI Creative Commons
Zifang Shang, Vipasha Sharma, Liu Pai

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 6, 2025

The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate Streptomyces kanamyceticus from local soil samples and evaluate its properties, along with optimizing production bioactive compounds. Soil were collected regions, processed, analysed strains isolation using morphological characteristics molecular identification through 16S rRNA gene PCR assay. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans double-layer method, while Minimum Inhibitory Concentration (MIC) values determined. extracted compounds underwent Fourier Transform Infrared Spectroscopy (FTIR) analysis functional group identification. Optimization compound performed a Central Composite Design (CCD) coupled Partial Least Squares Regression (PLSR). A total 25 distinct isolated, seven confirmed as S. kanamyceticus. These exhibited activity, inhibition zones reaching 30 mm MIC between 20 70 µg/mL. extraction yielded 150-200 mL studies revealed that medium containing 10 g/L glucose glycine max meal maximized antibiotic production. is promising source antibiotics. combination microbial isolation, testing, statistical optimization successfully enhanced compounds, contributing effective agents resistant pathogens.

Language: Английский

Citations

2
Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies DOI Creative Commons
Tomasz Kowalczyk,

Martyna Muskała,

Anna Merecz-Sadowska

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1143 - 1143

Published: Sept. 22, 2024

Anthocyanins, a class of flavonoid compounds responsible for the vibrant colors many fruits and vegetables, have received considerable attention in recent years due to their potential health benefits. This review, focusing on evidence from both vitro vivo studies, provides comprehensive overview current state knowledge regarding health-promoting properties anthocyanins. The chemical structure diversity anthocyanins, bioavailability, mechanisms action at cellular molecular level are examined. Research antioxidant, anti-inflammatory, anticancer, neuroprotective effects anthocyanins is critically reviewed. Special emphasis placed role prevention treatment chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases. review also discusses challenges translating findings highlights importance considering dose, metabolism when assessing therapeutic concludes with identification gaps research suggestions future directions anthocyanin including need more long-term clinical trials investigations into synergistic other phytochemicals. analysis promising promoting human valuable insights researchers, professionals, nutraceutical industry. study new insights, it comprehensively investigates dual anti-inflammatory anticancer models. By uncovering biological variety natural sources, this not only expands our these level, but enhances relevance through validation. Furthermore, innovative use may lead important advances application future.

Language: Английский

Citations

14
Recent Advances in Non-Thermal Plasma for Seed Germination, Plant Growth, and Secondary Metabolite Synthesis: A Promising Frontier for Sustainable Agriculture DOI
Mayura Veerana, Sohail Mumtaz, Juie Nahushkumar Rana

et al.

Plasma Chemistry and Plasma Processing, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

Citations

10
Phytochemical analysis and enhanced production of alkaloids in non-dormant corm-derived callus of Gloriosa superba (L.) using plant growth regulators and abiotic elicitors DOI
Dexter Achu Mosoh, Ashok Kumar Khandel, Sandeep Kumar Verma

et al.

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2024, Volume and Issue: 156(3)

Published: Feb. 28, 2024

Language: Английский

Citations

9
Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery DOI Creative Commons

Jibon Kumar Paul,

Mahir Azmal,

Anm Shah Newaz Been Haque

et al.

Advances in Redox Research, Journal Year: 2024, Volume and Issue: 13, P. 100113 - 100113

Published: Aug. 31, 2024

Language: Английский

Citations

9
Alkaloids Unveiled: A Comprehensive Analysis of Novel Therapeutic Properties, Mechanisms, and Plant-Based Innovations DOI Creative Commons

L Sarvananda,

Hewa D.T. Madhuranga,

M.B.L.N. Kaushalya

et al.

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

9