Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Molecules, Journal Year: 2015, Volume and Issue: 20(12), P. 21138 - 21156

Published: Nov. 27, 2015

Overproduction of oxidants (reactive oxygen species and reactive nitrogen species) in the human body is responsible for pathogenesis some diseases. The scavenging these thought to be an effective measure depress level oxidative stress organisms. It has been reported that intake vegetables fruits inversely associated with risk many chronic diseases, antioxidant phytochemicals are considered health benefits. Antioxidant can found foods medicinal plants, play important role prevention treatment diseases caused by stress. They often possess strong free radical abilities, as well anti-inflammatory action, which also basis other bioactivities benefits, such anticancer, anti-aging, protective action cardiovascular diabetes mellitus, obesity neurodegenerative This review summarizes recent progress on benefits phytochemicals, discusses their potential mechanisms

Language: Английский

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Role of ROS and Nutritional Antioxidants in Human Diseases

Frontiers in Physiology, Journal Year: 2018, Volume and Issue: 9

Published: May 17, 2018

Overproduction of reactive oxygen species¬ (ROS) have been implicated in the development various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative digestive diseases. Under physiological conditions, concentrations ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination antioxidant-deficiency malnutrition may render individuals more vulnerable to oxidative stress, increases risk cancer occurrence. In addition, antioxidant defense overwhelmed during sustained inflammation obstructive pulmonary diseases, inflammatory bowel disease, disorders. Certain vitamins, vitamin D, essential regulating biochemical pathways that lead proper functioning organs. Antioxidant supplementation has shown attenuate endogenous depletion thus alleviating associated damage some clinical research. However, results antioxidants exert no favorable effects on disease progression. Thus, studies warranted investigate complicated interactions between different types for restoration redox balance under pathologic conditions. This review highlights potential roles nutritional pathogenesis several imbalance-related attenuation stress-induced damages.

Language: Английский

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Dietary Natural Products for Prevention and Treatment of Liver Cancer

Nutrients, Journal Year: 2016, Volume and Issue: 8(3), P. 156 - 156

Published: March 10, 2016

Liver cancer is the most common malignancy of digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, some edible macro-fungi. These their active components could affect development progression in various ways, inhibiting tumor cell growth metastasis, protecting against carcinogens, immunomodulating enhancing effects chemotherapeutic drugs. This review summarizes activities major bioactive constituents on discusses possible mechanisms action.

Language: Английский

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Healthy Effects of Plant Polyphenols: Molecular Mechanisms

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(4), P. 1250 - 1250

Published: Feb. 13, 2020

The increasing extension in life expectancy of human beings developed countries is accompanied by a progressively greater rate degenerative diseases associated with lifestyle and aging, most which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed reducing prevalence these conditions population limited to safer including physical/mental exercise, reduced caloric intake, proper diet convivial environment. claimed health benefits Mediterranean Asian diets have been confirmed many clinical trials epidemiological surveys. These characterized several features, low meat consumption, intake oils instead fats as lipid sources, moderate amounts red wine, significant fresh fruit vegetables. In particular, latter attracted popular scientific attention their content, though amounts, number molecules increasingly investigated healthy properties. Among latter, plant polyphenols raised remarkable interest community; fact, that Mediterranean/Asian can be traced back presence molecules, even though, some cases, contradictory results reported, highlights need further investigation. light trials, recent research has sought provide information on biochemical, molecular, epigenetic, cell biology modifications cell, organismal, animal, models cancer, metabolic, neurodegenerative pathologies, notably Alzheimer's Parkinson disease. findings reported last decade starting help decipher complex relations between homeostatic systems metabolic redox equilibrium, proteostasis, inflammatory response, establishing an solid molecular basis effects molecules. Taken together, data currently available, incomplete, providing rationale possible use natural polyphenols, or scaffolds, nutraceuticals contrast aging combat pathologies.

Language: Английский

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Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 6, 2019

Background: Genistein is one among the several other known isoflavones that can be found in different soybeans and soy products. The chemical name of genistein 4',5,7-trihydroxyisoflavone. has drawn attention scientific community because its potential beneficial effects on human dreadful diseases, such as cancer. Mechanistic insight reveals for apoptotic induction, cell cycle arrest, well anti-angiogenic, antimetastatic anti-inflammatory effects. Objective: purpose this review to unravel analyze various molecular mechanisms diverse cancer models. Data sources: English language literature was searched using databases, PubMed, ScienceDirect, EBOSCOhost, Scopus, Web Science Cochrane library. Key words used combinations included genistein, cancer, anticancer, prevention, treatment, vivo, vitro, clinical studies. Study selection: selection carried out strictly accordance with statement Preferred Reporting Items Systematic Reviews Meta-Analyses. extraction: Four authors independently extraction articles. synthesis: 79 papers were suitable use review. Conclusion: This covers interactions cellular targets It will help understand biology provoke them design novel therapeutic strategies.

Language: Английский

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Dietary Natural Products for Prevention and Treatment of Breast Cancer

Nutrients, Journal Year: 2017, Volume and Issue: 9(7), P. 728 - 728

Published: July 8, 2017

Breast cancer is the most common among females worldwide. Several epidemiological studies suggested inverse correlation between intake of vegetables and fruits incidence breast cancer. Substantial experimental indicated that many dietary natural products could affect development progression cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, cereals. Their anti-breast effects involve various mechanisms action, downregulating ER-α expression activity, inhibiting proliferation, migration, metastasis angiogenesis tumor cells, inducing apoptosis cell cycle arrest, sensitizing cells to radiotherapy chemotherapy. This review summarizes potential role their major bioactive components in prevention treatment special attention was paid action.

Language: Английский

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Reconfiguration of DNA methylation in aging

Mechanisms of Ageing and Development, Journal Year: 2015, Volume and Issue: 151, P. 60 - 70

Published: Feb. 20, 2015

A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in epigenetic field has highlighted effective impact deregulation, particularly DNA methylation, on aging. Age-associated alterations methylation are commonly grouped phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation genome and hypermethylation a number promoter-associated CpG islands. Surprisingly, specific regions show directional changes aged individuals suggesting importance these events for However, information obtained until now needs re-consideration due to recent discovery 5-hydroxymethylcytosine, new mark present genome. recapitulation factors involved regulation occurring will be described this review also considering data available 5 hmC.

Language: Английский

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Epigenetic regulation of Keap1-Nrf2 signaling

Free Radical Biology and Medicine, Journal Year: 2015, Volume and Issue: 88, P. 337 - 349

Published: June 24, 2015

Language: Английский

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Natural Products for the Management and Prevention of Breast Cancer

Evidence-based Complementary and Alternative Medicine, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 23

Published: Jan. 1, 2018

Among all types of cancer, breast cancer is one the most challenging diseases, which responsible for a large number related deaths. Hormonal therapy, surgery, chemotherapy, and radiotherapy have been used as treatment very long time. Due to severe side effects multidrug resistance, these approaches become increasingly ineffective. However, adoption complementary approach can be big solution this situation, it evident that compounds derived from natural source great deal anticancer activity. Natural fight against aggressiveness inhibit cancerous cell proliferation, modulate pathways. A research works are now focusing on dietary trying find out new more effective strategies patients. In review, we discussed some significant chemical with their mechanisms actions, potent by proper modifications further clinical research. Future anti-breast-cancer agents open horizon in treatment, will play role enhancing survival rate

Language: Английский

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Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4567 - 4567

Published: Sept. 14, 2019

Polyphenols are potent micronutrients that can be found in large quantities various food sources and spices. These compounds, also known as phenolics due to their phenolic structure, play a vital nutrient-based role the prevention of diseases such diabetes, cardiovascular diseases, neurodegenerative liver disease, cancers. However, function polyphenols disease therapy depends on dietary consumption biological properties. According American Cancer Society statistics, there will an expected rise 23.6 million new cancer cases by 2030. Due severity increased risk, it is important evaluate preventive measures associated with cancer. Relatively recently, numerous studies have indicated phytochemicals possess properties modifying epigenetic mechanisms modulate gene expression resulting regulation phytochemicals, when administrated dose-dependent combinatorial-based manner, enhanced effect changes, which crucial therapy. Hence, this review focus combined impact modifications DNA methylation histone well non-coding miRNAs for treatment types

Language: Английский

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