Health benefits of polyphenols: A concise review

Journal of Food Biochemistry, Journal Year: 2022, Volume and Issue: 46(10)

Published: June 13, 2022

Plants produce polyphenols, which are considered highly essential functional foods in our diet. They classified into several groups according to their diverse chemical structures. Flavanoids, lignans, stilbenes, and phenolic acids the four main families of polyphenols. Several vivo vitro research have been conducted so far evaluate health consequences. Polyphenols serve a vital function protection organism from external stimuli eliminating reactive oxygen species (ROS), instigators illnesses. present tea, chocolate, fruits, vegetables with potential positively influence human health. For instance, cocoa flavan-3-ols associated decreased risk myocardial infarction, stroke, diabetes. diet also help improve lipid profiles, blood pressure, insulin resistance, systemic inflammation. Quercetin, flavonoid, resveratrol, stilbene, linked improved cardiovascular Dietary polyphenols elicit therapeutic effects might be attributed, at least part, bidirectional association gut microbiome. This is because known affect microbiome composition ways that lead better Specifically, converts bioactive compounds effects. In this review, antioxidant, cytotoxicity, anti-inflammatory, antihypertensive, anti-diabetic actions described based on findings experimental trials. Practical applications The non-communicable diseases (NCDs) burden has increasing worldwide due sedentary lifestyle other factors such as smoking, junk food, etc. Scientific literature evidence supports use plant-based food agents could alleviate NCD's burden. Thus, consuming polyphenolic natural sources an effective solution mitigate NCDs concerns. It discussed how antioxidants medicinal plants prevent or repair damage caused by free radicals, oxidative stress.

Language: Английский

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Hallmarks of Health

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

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Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4080 - 4080

Published: Nov. 15, 2021

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for impairment and dementia is advanced age followed by other determinants such genetic, socioeconomic, environmental factors, including nutrition physical activity. In the next decades, a rise in cases expected due largely aging of world population. There no hitherto effective pharmaceutical therapies treat age-associated dementia, which underscores crucial role prevention. A relationship among diet, activity, lifestyle with function has been intensively studied mounting evidence supporting these development decline chief cause disability globally. Several dietary patterns, foods, nutrients have investigated this regard, some encouraging disappointing results. This review presents current effects components, supplements, sleep social engagement on prevention or delay onset age-related dementia.

Language: Английский

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Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 206 - 206

Published: Jan. 12, 2021

Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, they most abundant antioxidant human diet. Studies suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes may contribute prevention several chronic disorders like diabetes, obesity, hypertension, colon cancer. have structural diversity which impacts their bioavailability as accumulate large intestine extensively metabolized through gut microbiota (GM). Intestinal transforms into metabolites make them bioactive. Interestingly, not only GM act on metabolize but also modulate composition GM. Thus, change from pathogenic beneficial ones health associated diseases. However, overcome low PPs, various approaches been developed improve solubility transportation gut. In this review, we present evidence supporting changes occur after reactions (curcumin, quercetin, catechins) effect leads improving overall helping disorders.

Language: Английский

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<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p>

Drug Design Development and Therapy, Journal Year: 2020, Volume and Issue: Volume 14, P. 4735 - 4748

Published: Nov. 1, 2020

Abstract: Salvia miltiorrhiza: (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear stasis. In this view, it widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, congenital defects. Tanshinone IIA (tan-IIA) the main fat-soluble component of miltiorrhiza . Modern pharmacological study shows that tan-IIA has anti-inflammatory anti-oxidant activities. Tan-IIA induces remarkable cardioprotective effects via angiogenesis which may serve as an effective treatment cardiovascular diseases (CVD). There also evidence extensive immunomodulatory plays role in development function immune cells. reduces production inflammatory mediators restores abnormal signaling pathways regulating activation It can regulate signal transduction pathways, ie, TLR/NF-κB pathway MAPKs/NF-κB pathway, thereby anti-inflammatory, anticoagulant, antithrombotic neuroprotective role. protective pathogenesis disorders (ie, atherosclerosis, hypertension) Alzheimer's disease. been revealed anti-tumor by killing various tumor cells, inducing differentiation apoptosis, potential activity carcinoma progression. review fact, different its mechanism have summarized while clinical applications are explored to provide new perspective An on action great significance for use herbal medicine promotion status influence world. Keywords: tanshinone-IIA, Alzheimer' disease, cancer, anti-inflammation, anti-oxidative

Language: Английский

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Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1044 - 1044

Published: June 29, 2021

Oxidative stress and inflammation triggered by increased oxidative are the cause of many chronic diseases. The lack anti-inflammatory drugs without side-effects has stimulated search for new active substances. Plant-derived compounds provide potential antioxidant molecules. Natural products structurally optimized evolution to serve particular biological functions, including regulation endogenous defense mechanisms interaction with other organisms. This property explains their relevance infectious diseases cancer. Recently, among various natural substances, polyphenols from extra virgin olive oil (EVOO), an important element Mediterranean diet, have aroused growing interest. Extensive studies shown potent therapeutic effects these bioactive molecules against a series diseases, such as cardiovascular diabetes, neurodegenerative disorders review begins chemical structure, abundance bioavailability main EVOO highlight possible molecular mechanism(s) action oxidation, in vitro vivo. In addition, inhibition signaling pathways activated discussed, together roles inflammation-mediated disorders, also taking into account meta-analysis population clinical trials.

Language: Английский

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Natural polyphenols in drug delivery systems: Current status and future challenges

Giant, Journal Year: 2020, Volume and Issue: 3, P. 100022 - 100022

Published: Aug. 1, 2020

Natural polyphenols have attracted great interests in medicine, food and cosmetics due to their versatile functions such as antioxidant, anticancer antibacterial. The polyphenolic structures (i.e. catechol, pyrogallol) natural are responsible for strong noncovalent interactions via multiple hydrogen bonding hydrophobic interactions, dynamic covalent complexation with boronate groups metal ions. In this review, we focused on the preparation applications of polyphenol-based coating films, nanoparticles, nanocapsules, hydrogels emerged from chemical functional signatures. beneficial role mechanism facilitating delivery proteins, nucleic acids conventional drug molecules were reviewed. Finally, challenges systems perspectives rational design next generation polyphenol biomaterials will be discussed.

Language: Английский

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Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties

Antioxidants, Journal Year: 2022, Volume and Issue: 11(1), P. 133 - 133

Published: Jan. 7, 2022

Flavonoids display a broad range of health-promoting bioactivities. Among these, their capacity to act as antioxidants has remained most prominent. The canonical reactive oxygen species (ROS)-scavenging mode the antioxidant action flavonoids relies on high susceptibility phenolic moieties undergo oxidation. As consequence, upon reaction with ROS, is severely compromised. Other phenol-compromising reactions, such those involved in biotransformation flavonoids, can also markedly affect properties. In recent years, however, increasing evidence indicated that, at least for some oxidation residues fact enhance original apparent paradoxical cases, activity arises from pro-oxidant and/or electrophilic character oxidation-derived metabolites and exerted by activating Nrf2-Keap1 pathway, which upregulates cell's endogenous capacity, and/or, preventing activation pro-inflammatory NF-κB pathway. This review focuses effects that oxidative non-oxidative modification groups may have ability resulting promote direct indirect actions. Considering case metabolite quercetin, we offer comprehensive description increasingly supports concept certain phenolics emerges mechanism amplifies An overlooked topic great phytomedicine potential thus unraveled.

Language: Английский

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Polyphenol and flavonoid profiles and radical scavenging activity in leafy vegetable Amaranthus gangeticus

BMC Plant Biology, Journal Year: 2020, Volume and Issue: 20(1)

Published: Nov. 2, 2020

Abstract Background Red amaranth ( Amaranthus gangeticus L . ) has great diversity in Bangladesh, India, and South East Asia with multipurpose uses. The bright red-violet colored A. is a popular low-cost leafy vegetable the Asian continent including Bangladesh India because of attractive leaf color, taste, adequate nutraceuticals, phenolic compounds, sole source betalains. natural colors compounds this species have significant role promoting health-benefit scavenging capacity radicals, colorant food products, play vital industry foods. However, profiles radical activity not been evaluated Hence, for first time, four selected advance lines were characterized profiles, antioxidant constituents, potentiality. Results genotypes are abundant sources constituents good quenching that differed across genotypes. Twenty-five acids flavonoids, such as protocatechuic acid, salicylic gentisic gallic β-resorcylic vanillic p -hydroxybenzoic chlorogenic ellagic syringic ferulic kaempferol, m -coumaric trans -cinnamic quercetin, apigenin, caffeic rutin, sinapic isoquercetin, naringenin, myricetin, catechin, hyperoside identified accessions. accessions LS7 LS9 demonstrated ample acids, It revealed from correlation study components exhibited activities. could be directly used enrich cultivars. Conclusions flavonoids privilege comprehensive pharmacology. basic information on achieved present will provide scientist’s forum scientific assessment these

Language: Английский

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Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis

Pharmacological Research, Journal Year: 2020, Volume and Issue: 160, P. 105056 - 105056

Published: July 2, 2020

Language: Английский

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