Health benefits of polyphenols: A concise review

Journal of Food Biochemistry, Journal Year: 2022, Volume and Issue: 46(10)

Published: June 13, 2022

Plants produce polyphenols, which are considered highly essential functional foods in our diet. They classified into several groups according to their diverse chemical structures. Flavanoids, lignans, stilbenes, and phenolic acids the four main families of polyphenols. Several vivo vitro research have been conducted so far evaluate health consequences. Polyphenols serve a vital function protection organism from external stimuli eliminating reactive oxygen species (ROS), instigators illnesses. present tea, chocolate, fruits, vegetables with potential positively influence human health. For instance, cocoa flavan-3-ols associated decreased risk myocardial infarction, stroke, diabetes. diet also help improve lipid profiles, blood pressure, insulin resistance, systemic inflammation. Quercetin, flavonoid, resveratrol, stilbene, linked improved cardiovascular Dietary polyphenols elicit therapeutic effects might be attributed, at least part, bidirectional association gut microbiome. This is because known affect microbiome composition ways that lead better Specifically, converts bioactive compounds effects. In this review, antioxidant, cytotoxicity, anti-inflammatory, antihypertensive, anti-diabetic actions described based on findings experimental trials. Practical applications The non-communicable diseases (NCDs) burden has increasing worldwide due sedentary lifestyle other factors such as smoking, junk food, etc. Scientific literature evidence supports use plant-based food agents could alleviate NCD's burden. Thus, consuming polyphenolic natural sources an effective solution mitigate NCDs concerns. It discussed how antioxidants medicinal plants prevent or repair damage caused by free radicals, oxidative stress.

Language: Английский

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Benefits of Dietary Polyphenols and Polyphenol-Rich Additives to Aquatic Animal Health: An Overview

Reviews in Fisheries Science & Aquaculture, Journal Year: 2020, Volume and Issue: 29(4), P. 478 - 511

Published: Sept. 14, 2020

Polyphenols are plant-derived compounds with known biological activities and potential health benefits. Over the past decade, there an increasing number of studies have investigated application polyphenols polyphenol-rich additives in aquaculture as functional feed additives. There several types polyphenolic such flavonoids, phenolic acids, lignans, stilbenes widely beneficial influences on overall performances immunity fish, thereby improving status production fish farms. This review discusses applications, optimum recommended dose, side effects these natural growth performance, proximate body composition, immune responses, disease resistance, reproductive fillet quality different species. Also, it points out that functions mechanisms associated involved pathways antioxidant pro-oxidant activities, well modulation gene expression parameters. The output this article provided overwhelming evidence to support claim can be considered relatively safe viable alternatives synthetic chemical not only improve but also enhance quality, productivity, food safety while reducing use chemicals antibiotics aquatic eco-systems.

Language: Английский

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Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Aging, Journal Year: 2021, Volume and Issue: 13(7), P. 9419 - 9432

Published: March 30, 2021

Manipulations to slow biological aging and extend healthspan are of interest given the societal healthcare costs our population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between ages 50-72. The 8-week treatment program included diet, sleep, exercise relaxation guidance, supplemental probiotics phytonutrients. control group received no intervention. Genome-wide DNA methylation analysis was saliva samples using Illumina Methylation Epic Array DNAmAge calculated online Horvath clock (2013). diet lifestyle associated with 3.23 years decrease in compared controls (p=0.018). those decreased by an average 1.96 end same individuals at beginning strong trend towards significance (p=0.066). Changes blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) triglycerides (-25%, p=0.009). To knowledge, this is first study suggest that specific interventions may reverse (2013) epigenetic males. Larger-scale longer duration trials needed confirm these findings, as well investigation other human populations.

Language: Английский

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Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies

Nutrients, Journal Year: 2019, Volume and Issue: 12(1), P. 108 - 108

Published: Dec. 30, 2019

Alcohol has a hormetic physiological behavior that results in either increased or decreased cardiovascular risk depending on the amount consumed, drinking frequency, pattern of consumption, and outcomes under study even type alcoholic beverage consumed. However, vast majority studies elucidating role alcohol global burden disease relies epidemiological associative nature which carry several limitations. This is why benefits low-moderate consumption are being questioned perhaps might have been overestimated. Thus, aim this review was to critically discuss current knowledge relationship between intake disease. Besides new evidence associating low moderate with disease, questions remain unanswered related concrete safe beverage, age-, sex-, genetic/ethnical-specific differences consumption.

Language: Английский

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Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Nutrients, Journal Year: 2021, Volume and Issue: 13(3), P. 724 - 724

Published: Feb. 25, 2021

Epidemiological studies have shown a dramatic increase in the incidence and prevalence of allergic diseases over last several decades. Environmental triggers including risk factors (e.g., pollution), loss rural living conditions farming conditions), nutritional status maternal, breastfeeding) are considered major contributors to this increase. The influences these environmental thought be mediated by epigenetic mechanisms which heritable, reversible, biologically relevant biochemical modifications chromatin carrying genetic information without changing nucleotide sequence genome. An important feature characterizing epigenetically-mediated processes is existence time frame where induced effects strongest therefore most crucial. This period between conception, pregnancy, first years life 1000 days) optimal for factors, such as nutrition, exert their beneficial effects. In current review, we discussed impact exposure bacteria, viruses, parasites, fungal components, microbiome metabolites, specific components polyunsaturated fatty acids (PUFA), vitamins, plant- animal-derived microRNAs, breast milk) on patterns related manifestations. We gave insight into signature bioactive milk nutrition neonatal T cell development. Several lines evidence suggest that atypical metabolic reprogramming extrinsic allergens, pollutants, diet, or might drive cellular dysfunctions defective immune responses disease. Therefore, described knowledge relationship immunometabolism allergy mechanisms. presented will give changes potential maternal post-natal development

Language: Английский

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Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3519 - 3519

Published: Aug. 26, 2022

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin received the most attention among these molecules due to their documented antioxidant effects. The review aims investigate effects of on bone metabolism role in several diseases such as osteopenia osteoporosis, tumours, periodontitis. PubMed/Medline, Web Science, Google Scholar, Scopus, Cochrane Library, Embase electronic databases were searched for papers line with study topic. According an English language restriction, screening period was from January 2012 3 July 2022, following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” (“quercetin” “bone”). A total 36 identified relevant purpose our investigation. studies positive investigated phenolic potential application adjuvant treatments Furthermore, use titanium surfaces orthopaedic prostheses could represent a possible improve osteogenic processes osseointegration. findings, resveratrol, wide variety beneficial supplement therapies. seem positively mediate osteoclast-related pathologies.

Language: Английский

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The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 19

Published: Feb. 15, 2022

Cancer is one of the greatest causes death worldwide. With development surgery, radiotherapy, and medical agents, outcomes cancer patients have greatly improved. However, underlying mechanisms are not yet fully understood. Recently, natural products been proven to be beneficial for various conditions played important roles in novel therapies. A substantial amount evidence indicates that bioactive compounds could improve via pathways, such as endoplasmic reticulum stress, epigenetic modification, modulation oxidative stress. Here, we review current treatment summarize this pathological process.

Language: Английский

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Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10244 - 10244

Published: Sept. 6, 2022

Polyphenols represent a structural class of mainly natural organic chemicals that contain multiple phenol units. The beneficial properties polyphenols have been extensively studied for their antitumor, anti-inflammatory, and antibacterial effects, but nowadays, medical applications are starting to be extended many other due prebiotic role impact on the microbiota. This review focused use in cancer treatment. Their antineoplastic effects demonstrated various studies when they were tested numerous lines some vivo models. A431 SCC13 human skin cell treated with EGCG presented reduced viability enhanced death inactivation β-catenin signaling. Additionally, resveratrol showed great potential against breast its ability exert both anti-estrogenic estrogenic (based concentration) because it has high affinity estrogen receptors ERα Erβ. can combined different classical cytostatic agents enhance therapeutic cells also protect healthy from aggressiveness antitumor drugs anti-inflammatory properties. For instance, curcumin reported reduce gastrointestinal toxicity associated chemotherapy. In case 5-FU-induced, by increasing intestinal permeability inhibiting mucosal damage. Co-administration doxorubicin induced liver cells. inhibit autophagic activity stop hepatoma Hep3B proliferation symbiotic approach is well-known practice including

Language: Английский

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Mediterranean Diet: The Role of Phenolic Compounds from Aromatic Plant Foods

Foods, Journal Year: 2023, Volume and Issue: 12(4), P. 840 - 840

Published: Feb. 16, 2023

Today’s global food system aggravates climate change while failing in meeting SDG2 and more. Yet, some sustainable cultures, such as the Mediterranean Diet (MD), are simultaneously safe, healthy, rooted biodiversity. Their wide range of fruits, herbs, vegetables convey many bioactive compounds, often associated with colour, texture, aroma. Phenolic compounds largely responsible for features MD’s foods. These plant secondary metabolites all share vitro bioactivities (e.g., antioxidants), evidenced vivo sterols lower cholesterol levels blood). The present work examines role polyphenols MD, respect to human planetary health. Since commercial interest is increasing, a strategy exploitation plants essential preserving species at risk valuing local cultivars through geographical indication mechanism). Finally, linkage habits cultural landscapes, cornerstone should enable awareness-raising about seasonality, endemism, other natural constraints ensure plants.

Language: Английский

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Benefits of Natural Antioxidants on Oral Health

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1309 - 1309

Published: June 20, 2023

In recent years, special attention has been paid to the correlation between oxidation–reduction mechanisms and human health. The free radicals produced via physiological cellular biochemical processes are major contributors oxidation phenomena. Their instability is cause of damage. Free radical reactive oxygen species containing best-known ones. body neutralises harmful effects production endogenous antioxidants (superoxide dismutase, catalase, glutathione, melatonin). field study nutraucetics found antioxidant capacity in substances such as vitamins A, B, C, E, coenzyme Q-10, selenium, flavonoids, lipoic acid, carotenoids, lycopene contained some foods. There several areas investigation that aim research interaction species, exogenous antioxidants, microbiota promote increased protection peroxidation macromolecules (proteins, lipids) by maintaining a dynamic balance among make up microbiota. this scoping review, we map scientific literature on oxidative stress related oral microbiota, use natural counteract it, assess volume, nature, characteristics, type studies available date, suggest possible gaps will emerge from analysis.

Language: Английский

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