Improved tools to study astrocytes

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 121 - 138

Published: Feb. 10, 2020

Language: Английский

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Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(10), P. 1229 - 1239

Published: Aug. 3, 2020

Language: Английский

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Behaviorally consequential astrocytic regulation of neural circuits

Neuron, Journal Year: 2020, Volume and Issue: 109(4), P. 576 - 596

Published: Dec. 31, 2020

Language: Английский

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Making sense of astrocytic calcium signals — from acquisition to interpretation

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(10), P. 551 - 564

Published: Sept. 1, 2020

Language: Английский

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G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, Journal Year: 2020, Volume and Issue: 456, P. 71 - 84

Published: March 26, 2020

Language: Английский

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Astrocytes and Behavior

Annual Review of Neuroscience, Journal Year: 2021, Volume and Issue: 44(1), P. 49 - 67

Published: Jan. 6, 2021

Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, are numerous neurons in the mammalian brain, and current findings indicate a chemically based dialog between neurons. Activation of synaptically released neurotransmitters converges on regulating intracellular Ca2+ astrocytes, which then can regulate efficacy near distant tripartite synapses at diverse timescales through gliotransmitter release. Here, we discuss recent evidence how behaviors impacted this dialog. These support paradigm shift neuroscience, animal does not result from activity but coordinated both Decoding interact with each other various brain circuits will fundamental fully understanding originate become dysregulated disease.

Language: Английский

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Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 17, 2021

Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological activity, underlies several critical functions, including learning and memory. However, NREM sleep is heterogeneous, varying in duration, depth, spatially across the cortex. While these features are thought to be largely independently regulated, there also evidence that they mechanistically coupled. To investigate how cortical controlled, we examined astrocytic network, comprising a cortex-wide syncytium influences population-level neuronal activity. We quantified endogenous astrocyte activity mice over natural wake, then manipulated specific G-protein-coupled receptor (GPCR) signaling pathways vivo. find Gi- Gq-coupled GPCR separately control depth respectively, causes differential changes local remote These data support model which network serves as hub for regulating distinct features.

Language: Английский

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From Synapses to Circuits, Astrocytes Regulate Behavior

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 4, 2022

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior. ensheath synapses to form the tripartite synapse where astrocytes influence formation, function, plasticity. Beyond synapse, recent research has revealed astrocyte influences on nervous system extend modulation of circuitry Here we review findings active role in behavioral with a focus vivo studies, primarily mice. Using tools acutely manipulate astrocytes, such as optogenetics or chemogenetics, studies reviewed here have demonstrated causal for sleep, memory, sensorimotor behaviors, feeding, fear, anxiety, cognitive processes like attention flexibility. Current future directions astrocyte-specific manipulation, including methods probing heterogeneity, discussed. Understanding contribution circuit activity organismal behavior will be critical toward understanding how function gives rise

Language: Английский

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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Cell Reports, Journal Year: 2022, Volume and Issue: 40(8), P. 111280 - 111280

Published: Aug. 1, 2022

Dysfunctions of network activity and functional connectivity (FC) represent early events in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes regulate local neuronal healthy brain, their involvement hyperactivity AD is unknown. We show increased FC human cingulate cortex several years before amyloid deposition. find same disruption AppNL-F mice. Crucially, these disruptions are accompanied by decreased astrocyte calcium signaling. Recovery astrocytic normalizes FC, as well seizure susceptibility day/night behavioral disruptions. In conclusion, we that astrocytes mediate initial features drive clinically relevant phenotypes.

Language: Английский

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Astrocyte regulation of neural circuit activity and network states

Glia, Journal Year: 2022, Volume and Issue: 70(8), P. 1455 - 1466

Published: April 22, 2022

Abstract Astrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels ions and neurotransmitters exchange signaling molecules that regulate synaptic formation, structure, function. While a great effort done in past has defined many molecular mechanisms cellular processes involved astrocyte‐neuron interactions at level, consequences these network level vivo have only relatively recently been identified. This review describes discusses recent findings on regulatory effects astrocytes networks vivo. Accumulating but still limited, evidence indicates rhythmic synchronization as well brain states. These studies demonstrate critical contribution paving way for more thorough understanding bases

Language: Английский

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