Real-time fMRI amygdala neurofeedback positive emotional training normalized resting-state functional connectivity in combat veterans with and without PTSD: a connectome-wide investigation DOI Creative Commons
Masaya Misaki,

Raquel Phillips,

Vadim Zotev

et al.

NeuroImage Clinical, Journal Year: 2018, Volume and Issue: 20, P. 543 - 555

Published: Jan. 1, 2018

Self-regulation of brain activation using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) is an emerging approach for treating mood and anxiety disorders. The effect training on resting-state connectivity warrants investigation as changes in spontaneous could reflect the association between sustained symptom relief alteration. We investigated amygdala-focused rtfMRI-nf combat veterans with without posttraumatic stress disorder (PTSD) who were trained to increase a feedback signal reflecting left amygdala activity while recalling positive autobiographical memories (Zotev et al., 2018). analysis was performed three stages: i) first, we region; ii) next, focused abnormal identified our previous this data (Misaki 2018); iii) finally, novel data-driven longitudinal connectome-wide analysis. introduced multivariate distance matrix regression (MDMR) comprehensively examine effects beyond those associated baseline connectivity. These comprehensive exploratory analyses suggested that PTSD partly normalized after training. This included hypoconnectivities ventrolateral prefrontal cortex (vlPFC) supplementary motor area (SMA) dorsal anterior cingulate (dACC). SMA-dACC reduction. Longitudinal MDMR found change precuneus superior frontal cortex. decrease hyperarousal symptoms. - such hypoconnectivity region hyperconnectivity posterior insula several regions also be results not limited target mediated by modulation other than area. While further confirmatory research needed, may provide valuable insight into treatment whole

Language: Английский

Positive and Negative Emotion Regulation in Adolescence: Links to Anxiety and Depression DOI Creative Commons
Katherine S. Young, Christina F. Sandman, Michelle G. Craske

et al.

Brain Sciences, Journal Year: 2019, Volume and Issue: 9(4), P. 76 - 76

Published: March 29, 2019

Emotion regulation skills develop substantially across adolescence, a period characterized by emotional challenges and developing regulatory neural circuitry. Adolescence is also risk for the new onset of anxiety depressive disorders, psychopathologies which have long been associated with disruptions in positive negative emotions. This paper reviews current understanding role disrupted emotion adolescent depression, describing findings from self-report, behavioral, peripheral psychophysiological, measures. Self-report studies robustly identified associations between dysregulation depression. Findings behavioral psychophysiological are mixed, some suggestion specific impairments reappraisal anxiety. Results neuroimaging broadly implicate altered functioning amygdala-prefrontal cortical circuitries, although again, mixed regarding patterns functioning. Future work may benefit focusing on designs that contrast effects strategies, isolate changes reactivity. Approaches to improve treatments based empirical evidence adolescents discussed. intervention might consider training measurement strategies better understand as treatment mechanism.

Language: Английский

Citations

326
Neurofeedback with fMRI: A critical systematic review DOI
Robert T. Thibault, Amanda MacPherson, Michael Lifshitz

et al.

NeuroImage, Journal Year: 2017, Volume and Issue: 172, P. 786 - 807

Published: Dec. 27, 2017

Language: Английский

Citations

301
fMRI neurofeedback in emotion regulation: A literature review DOI
Pavla Linhartová,

Adéla Látalová,

Barbora Kóša

et al.

NeuroImage, Journal Year: 2019, Volume and Issue: 193, P. 75 - 92

Published: March 9, 2019

Language: Английский

Citations

148
Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review DOI Creative Commons
Frank W. Paulus, Susanne Ohmann, Eva Möhler

et al.

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 25, 2021

Background: Emotional dysregulation (ED) is a transdiagnostic construct defined as the inability to regulate intensity and quality of emotions (such as, fear, anger, sadness), in order generate an appropriate emotional response, handle excitability, mood instability, overreactivity, come down baseline. Because ED has not been clinical entity, because plays major role child adolescent psychopathology, we decided summarize current knowledge on this topic based narrative review literature. Methods: This literature search peer-reviewed journals. We searched databases ERIC, PsycARTICLES, PsycINFO PSYNDEX June 2, 2020 for peer reviewed articles published between 2000 English language preschool, school, age (2-17 years) using following terms: "emotional dysregulation" OR "affect dysregulation," retrieving 943 articles. Results: The results are presented sections: relationship psychiatric disorders (ADHD, Mood Disorders, Psychological Trauma, Posttraumatic Stress Disorder, Non-suicidal Self-Injury, Eating Oppositional Defiant Conduct Disruptive Dysregulation Personality Substance Use Developmental Autism Spectrum Psychosis Schizophrenia, Gaming Disorder), prevention, treatment ED. Conclusion: Basic conditions genetic disposition, experience trauma, especially sexual or physical abuse, neglect childhood adolescence, personal stress. complex comprehensive concept, aggravating number various mental disorders. Differential mandatory individual social functioning.

Language: Английский

Citations

119
Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry DOI Open Access
Andrew A. Nicholson, Karl Friston, Peter Zeidman

et al.

Human Brain Mapping, Journal Year: 2017, Volume and Issue: 38(11), P. 5551 - 5561

Published: Aug. 24, 2017

Posttraumatic stress disorder (PTSD) is associated with decreased top-down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients dissociative subtype (PTSD + DS) often exhibit increased mPFC amygdala activation emotional detachment hypoarousal. Crucially, DS display distinct functional connectivity within PFC, complexes, periaqueductal gray (PAG), region related to defensive responses/emotional coping. However, differences in directed between these regions have not been established PTSD, DS, or controls.To examine (effective) among nodes, as well group differences, we conducted resting-state stochastic dynamic causal modeling (sDCM) pairwise analyses coupling ventromedial (vm)PFC, bilateral basolateral centromedial (CMA) PAG, 155 participants [n = 62]; 41]; age-matched healthy trauma-unexposed controls 52]).PTSD was characterized pattern predominant bottom-up vmPFC PAG Conversely, exhibited all node pairs (from PAG). Interestingly, displayed strongest intrinsic inhibitory connections vmPFC.These results suggest contrasting symptom profiles its (hyper- vs. hypo-emotionality, respectively) may be driven complementary changes corresponding fear processing versus enhanced regulation. Hum Brain Mapp 38:5551-5561, 2017. © 2017 Wiley Periodicals, Inc.

Language: Английский

Citations

135
Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience DOI

Jackob N. Keynan,

Avihay Cohen,

Gilan Jackont

et al.

Nature Human Behaviour, Journal Year: 2018, Volume and Issue: 3(1), P. 63 - 73

Published: Dec. 7, 2018

Language: Английский

Citations

134
A systematic review of the psychological factors that influence neurofeedback learning outcomes DOI
Kathrin Cohen Kadosh,

Graham Staunton

NeuroImage, Journal Year: 2018, Volume and Issue: 185, P. 545 - 555

Published: Oct. 10, 2018

Language: Английский

Citations

133
A Randomized Controlled Study of Neurofeedback for Chronic PTSD DOI Creative Commons
Bessel A. van der Kolk, Hilary Hodgdon, Mark Gapen

et al.

PLoS ONE, Journal Year: 2016, Volume and Issue: 11(12), P. e0166752 - e0166752

Published: Dec. 16, 2016

Brain/Computer Interaction (BCI) devices are designed to alter neural signals and, thereby, mental activity. This study was a randomized, waitlist (TAU) controlled trial of BCI, EEG neurofeedback training (NF), in patients with chronic PTSD explore the capacity NF reduce symptoms and increase affect regulation capacities.52 individuals were randomized either (n = 28) or (WL) 24). They completed four evaluations, at baseline (T1), after week 6 (T2), post-treatment (T3), one month follow up (T4). Assessment measures were:1. Traumatic Events Screening Inventory (T1); 2. Clinician Administered Scale (CAPS; T1, T3, T4); 3. Davidson Trauma (DTS; T1-T4) 4. Altered Self-Capacities (IASC; T1-T4). occurred two times per for 12 weeks involved sequential placement T4 as active site, P4 reference site.Participants had experienced an average 9.29 (SD 2.90) different traumatic events. Post-treatment significantly smaller proportion (6/22, 27.3%) met criteria than WL condition (15/22, 68.2%), χ2 44, df 1) 7.38, p .007. There significant treatment x time interaction (b -10.45, t -5.10, p< .001). Measures tension reduction activities, dysregulation, instability exhibited Time Condition interaction. The effect sizes (d -2.33 within, d - 1.71 between groups) comparable those reported most effective evidence based treatments PTSD.Compared control group produced symptom improvement PTSD, well capacities. deserves further investigation its potential ameliorate improve regulation, clarify mechanisms action.

Language: Английский

Citations

132
Functional Neuroanatomy of Emotion and Its Regulation in PTSD DOI
Jacklynn M. Fitzgerald,

Julia A. DiGangi,

K. Luan Phan

et al.

Harvard Review of Psychiatry, Journal Year: 2018, Volume and Issue: 26(3), P. 116 - 128

Published: May 1, 2018

Abstract Posttraumatic stress disorder (PTSD) is a devastating disorder, linked to profound mental, physical, occupational, and functional impairment. In addition, it highly complex characterized by symptom heterogeneity across multiple domains. Nevertheless, emotion dysregulation arising from the exaggerated response threat or inability regulate negative emotional states plays defining role in pathophysiology of PTSD. order improve our understanding how manifests this illness, neuroimaging research over past 20 years provides great insight into underlying neuroanatomy each component context While prior reviews exist on topic findings PTSD, present review synthesizes that work through lens its regulation. Studies employed tasks responding provocation, implicit regulation (e.g., Stroop interference), explicit cognitive reappraisal), fear conditioning/extinction were reviewed. Findings demonstrate PTSD arises complications within large neurocircuitry involving amygdala, insula, hippocampus, anterior cingulate cortex, prefrontal cortex. Although an amygdala insula triggers pervasive, also marked deficient appraisal, resolution, management subserved cortex during These further support importance studying emotion-regulation deficits tandem with provocation better understand constellation symptoms those

Language: Английский

Citations

132
Training emotion regulation through real-time fMRI neurofeedback of amygdala activity DOI
Uwe Herwig, J. Gary Lutz,

Sigrid Scherpiet

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 184, P. 687 - 696

Published: Oct. 1, 2018

Language: Английский

Citations

127