The impact of COVID‐19 on head and neck cancer diagnosis and disease extent

Head & Neck, Journal Year: 2021, Volume and Issue: 43(6), P. 1890 - 1897

Published: March 2, 2021

Due to COVID-19, diagnostic delays and a surge of advanced head neck cancer (HNC) is anticipated. We hereby evaluate patient tumor characteristics before during the early COVID-19 period.Retrospective review patients with HNC presented at multidisciplinary conference from May 14, 2020 June 18, was performed compared similar 6-week period year before. Demographics, time diagnosis, were analyzed.There 25% reduction in newly diagnosed malignancies. Groups baseline characteristics, duration symptoms, diagnosis. However, median primary size significantly larger (p = 0.042) T stage more for mucosal subsites 0.025) group.Our findings suggest increased burden presenting pandemic, despite This may become pronounced as pandemic extended.

Language: Английский

---

The impact of the COVID-19 pandemic on time to treatment in head and neck cancer management: a systematic review

Acta Oncologica, Journal Year: 2025, Volume and Issue: 64, P. 156 - 166

Published: Jan. 28, 2025

Background and purpose: Coronavirus disease 2019 (COVID-19) caused a need for reorganization in the healthcare systems. First, we aimed to determine impact of COVID-19 pandemic on time treatment head neck cancer (HNC) patients. Second, tumor stage changes regimens used. Material methods: A systematic search PubMed Embase was conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines. Inclusion criteria were: (1) Studies including patients with squamous cell carcinomas; (2) containing comparison treatment; (3) well-defined interval restrictions health care due without restrictions. Results: total 19 studies were included comprising 24,898 treated HNC cancer. Six (10.1% patients) reported an increase waiting within at least one interval, while seven decrease (83.2% patients), six found no significant effect. No modalities observed. Seven 15 (12.7% observed either overall stage, size, or node metastasis classification during pandemic. Among these, two increased times as well. Interpretation: The COIVD-19 heterogenous subject considerable intercountry interregional variations. tendency toward higher T-classification In conclusion, otorhinolaryngology departments demonstrated resilience, led only slight alterations treatment.

Language: Английский

---

The Impact of COVID‐19 on Head and Neck Cancer Treatment: Before and During the Pandemic

OTO Open, Journal Year: 2021, Volume and Issue: 5(4)

Published: Oct. 1, 2021

Objectives To describe the impact that coronavirus disease 2019 (COVID‐19) pandemic had on presentation of patients with head and neck cancer in a single tertiary care center. Study Design Retrospective cohort study. Setting Academic institution. Methods We performed retrospective review newly diagnosed squamous cell carcinoma (HNSCC) who presented as new between September 10, 2019, 11, 2020. Patients presenting during 6 months leading up to announcement (pre–COVID‐19 period) March 2020, were compared those first (COVID‐19 period). Demographics, time diagnosis treatment, tumor characteristics analyzed. Results There total 137 analyzed malignancies. 22% fewer evaluated COVID‐19 timeframe. The groups similar demographics, duration symptoms, diagnosis, surgery, extent adjuvant therapy. was larger proportion tumors classified T3/T4 (61.7%) period vs pre–COVID‐19 (40.3%) ( P =. 024), well median size 0002). no differences nodal burden 48) distant metastases 42). Conclusion Despite characteristics, our findings suggest there an increase primary HNSCC early pandemic.

Language: Английский

---

Changes in the quality of cancer care as assessed through performance indicators during the first wave of the COVID-19 pandemic in 2020: a scoping review

BMC Health Services Research, Journal Year: 2022, Volume and Issue: 22(1)

Published: June 17, 2022

Abstract Background Cancer comprises a high burden on health systems. Performance indicators monitoring cancer outcomes are routinely used in OECD countries. However, the development of process and cancer-pathway based information is essential to guide care delivery, allowing for better changes quality provided. Assessing during COVID-19 pandemic requires structured approach considering volume publications. This study aims summarize performance literature evaluate impact (January-June 2020) countries assess as reported via selected indicators. Methods Search conducted MEDLINE Embase databases. their trends were collated according pathway. Results included 135 articles, from which 1013 retrieved. Indicators assessing diagnostic showed decreasing trend: 33 reporting screening, 30 (91%) signalled decrease ( n = indicators, 91%). A reduction was also observed number procedures 64, 58%) diagnoses 130, 89%). The proportion emergency setting waiting times increasing 8, 89% 14, 56%, respectively). trend earliest stage cancers by 63% 9), 70% 43) an advanced-stage cancers. reflecting treatment procedures: 79%( 82) concerning surgeries, 72%( 41) radiotherapy, 93%( 40) related systemic therapies. Modifications frequently reported: 64%( 195) revealed treatment. Conclusions provides summary pathway January 2020 June countries, these inform potential bottlenecks Monitoring this closely could contribute identifying moments intervention crises.

Language: Английский

---

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(6), P. 402 - 413

Published: April 28, 2023

Language: Английский

---

Impact of the Sars-Cov-2 outbreak on the initial clinical presentation of new solid cancer diagnoses: a systematic review and meta-analysis

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract Background The COVID-19 pandemic might have delayed cancer diagnosis and management. aim of this systematic review was to compare the initial tumor stage new diagnoses before after pandemic. Methods We systematically reviewed articles that compared solid waves. conducted a random-effects meta-analysis rate metastatic tumors distribution stages at diagnosis. Subgroup analyses were performed by primary site country. Results From 2,013 studies published between January 2020 April 2022, we included 58 with 109,996 patients. higher outbreak than (pooled OR: 1.29 (95% CI, 1.06-1.57), I 2 : 89% 86-91)). For specific cancers, common ORs reached statistical significance for breast (OR: 1.51 CI 1.07-2.12)) gynecologic 1.04-2.18)) but not other types. According countries, OR CI) only Italy: 1.55 (1.01-2.39) Spain:1.14 (1.02-1.29). Rates comparable I-II versus III-IV in which information available, III did include Conclusions Despite inter-study heterogeneity, our showed burden social distancing policies explain those results, as patients may seeking care.

Language: Английский

---

Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(11), P. 3394 - 3418

Published: Oct. 14, 2024

Head and neck cancers (HNC) are aggressive, difficult-to-treat tumors that can be caused by genetic factors but mainly lifestyle or infection the human papillomavirus. As sixth most common malignancy, it presents a formidable therapeutic challenge with limited modalities. Curcumin, natural polyphenol, is appearing as promising multitarget anticancer antimetastatic agent. Numerous studies have shown curcumin its derivatives potential to affect signaling pathways (NF-κB, JAK/STAT, EGFR) molecular mechanisms crucial for growth migration of head tumors. Furthermore, ability interact tumor microenvironment trigger immune system may significantly influence organism's response tumor. Combining conventional therapies such chemotherapy radiotherapy improve efficacy treatment reduce side effects treatment, thereby increasing potential. This review comprehensive overview discusses both benefits limitations in context biology, an emphasis on HNC. also includes possibilities limiting properties terms development new derivatives, formulations, combinations type therapy HNC subsequent use clinical practice.

Language: Английский

---

Impact of COVID-19 on presentation, staging, and treatment of head and neck mucosal squamous cell carcinoma

American Journal of Otolaryngology, Journal Year: 2021, Volume and Issue: 43(1), P. 103263 - 103263

Published: Oct. 9, 2021

Language: Английский

---

The Impact of the COVID-19 Pandemic on Head and Neck Cancer Diagnosis in the Piedmont Region, Italy: Interrupted Time-Series Analysis

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Feb. 21, 2022

Background The COVID-19 pandemic has likely affected the most vulnerable groups of patients and those requiring time-critical access to healthcare services, such as with cancer. aim this study was use time trend data assess impact on timely diagnosis treatment head neck cancer (HNC) in Italian Piedmont region. Methods This based two different sources. First, regional hospital discharge register were used identify incident HNC ≥18 years old during period from January 1, 2015, December 31, 2020. Interrupted time-series analysis model long-time trends monthly before while accounting for holiday-related seasonal fluctuations admissions. Second, a population eligible recruitment an ongoing clinical cohort (HEADSpAcE) that started pandemic, we compared distribution early-stage late-stage diagnoses between pre-COVID-19 period. Results There 4,811 admissions 5-year outbreak 832 2020, which 689 occurred after Italy. An initial reduction 28% first wave (RR 0.72, 95% CI 0.62–0.84) largely addressed by end 2020 0.96, 0.89–1.03) when considering whole population, although there some heterogeneities. gap observed expected particularly evident had not completely recovered year older (≥75 years) (RR: 0.88, 0.76–1.01), Romano-Charlson comorbidity index below 2 0.91, CI: 0.84–1.00), primary surgically treated 0.80–0.97). In subgroup active recruitment, no evidence shift toward more advanced stage at periods following wave. Conclusions differentially management certain patients, pronounced primarily surgically, less comorbidities. missed delayed may translate into worser oncological outcomes these patients.

Language: Английский

---

Impact of the COVID‐19 pandemic on stage and incidence of head and neck cancer: A rapid review and meta‐analysis

Clinical Otolaryngology, Journal Year: 2024, Volume and Issue: 49(4), P. 363 - 375

Published: March 21, 2024

Abstract Objectives This rapid review aims to evaluate the impact of COVID‐19 pandemic on incidence head and neck cancer (HNC) stage distribution at diagnosis. Design Rapid meta‐analysis. Participants Comparative data for new HNC patients between a pre‐pandemic cohort (before March 2020) (after 2020 during lockdown period). Main Outcomes Measured Data tumour stage, incidence, referral pathway (number patient referrals), or workload levels treatments). were summarised as odds ratios (OR) with 95% confidence intervals (CI), related changes in numbers diagnoses, referrals, narrative synthesis. Results A total 31 reports included this review. Individually 16 out 23 studies did not show significant relative period. However, meta‐analysis revealed that diagnosed 16% more likely have nodal involvement (OR = 1.16; CI 1.00–1.35), 17% late overall 1.17; 1.01–1.36), 32% present advanced extent (T3 T4 stage) 1.32; 1.08–1.62). was extremely limited currently sufficient assess trends burden disease. Conclusions indicates pandemic, there upstaging diagnosis, suggesting provision care significantly affected.

Language: Английский

---