International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(23), P. 8894 - 8894
Published: Nov. 24, 2020
Epigenetics,
an
inheritable
phenomenon,
which
influences
the
expression
of
gene
without
altering
DNA
sequence,
offers
a
new
perspective
on
pathogenesis
hepatocellular
carcinoma
(HCC).
Nonalcoholic
steatohepatitis
(NASH)
is
projected
to
account
for
significant
share
HCC
incidence
due
growing
prevalence
various
metabolic
disorders.
One
major
molecular
mechanisms
involved
in
epigenetic
regulation,
post-translational
histone
modification
seems
coordinate
aspects
NASH
will
further
progress
HCC.
Mounting
evidence
suggests
that
orchestrated
events
cellular
and
nuclear
changes
during
apoptosis
can
be
regulated
by
modifications.
This
review
focuses
current
advances
study
acetylation-/methylation-mediated
implication
these
regulations
The
reversibility
alterations
agents
target
novel
therapeutic
approaches
strategies
drug
development.
Further
mechanistic
studies
are
required
enhance
information
governing
modulators,
facilitate
design
more
effective
diagnosis
treatment
options.
Biomedicine & Pharmacotherapy,
Journal Year:
2020,
Volume and Issue:
133, P. 111044 - 111044
Published: Dec. 13, 2020
Traditional
Chinese
Medicine
(TCM)
has
the
characteristics
of
multiple
targets,
slight
side
effects
and
good
therapeutic
effects.
Good
anti-tumor
are
shown
by
prescription,
patent
medicine,
single
medicine
monomer
compound.
Clinically,
TCM
prolonged
survival
time
patients
improved
life
quality
patients,
due
to
less
Cancer
metastasis
is
a
complex
process
involving
numerous
steps,
genes
their
products.
During
tumor
metastasis,
firstly,
cancer
cell
increases
its
proliferative
capacity
reducing
autophagy
apoptosis,
then
stimulated
increasing
ability
tumors
absorb
nutrients
from
outside
through
angiogenesis.
Both
two
steps
can
increase
migration
invasion.
Finally,
purpose
achieved.
By
inhibiting
apoptosis
cells,
angiogenesis
EMT
inhibit
invasion
cancer,
consequently
achieve
metastasis.
This
review
explores
research
achievements
on
breast
lung
hepatic
carcinoma,
colorectal
gastric
other
in
past
five
years,
summarizes
development
direction
years
makes
prospect
for
future.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(9), P. 3173 - 3173
Published: Sept. 11, 2021
Approximately
4%
of
cancers
worldwide
are
caused
by
alcohol
consumption.
Drinking
increases
the
risk
several
cancer
types,
including
upper
aerodigestive
tract,
liver,
colorectum,
and
breast.
In
this
review,
we
summarise
epidemiological
evidence
on
mechanistic
alcohol-mediated
carcinogenesis.
There
pathways
which
consumption
alcohol,
as
ethanol,
is
known
to
cause
cancer,
though
some
still
not
fully
understood.
Ethanol’s
metabolite
acetaldehyde
can
DNA
damage
block
synthesis
repair,
whilst
both
ethanol
disrupt
methylation.
Ethanol
also
induce
inflammation
oxidative
stress
leading
lipid
peroxidation
further
damage.
One-carbon
metabolism
folate
levels
impaired
ethanol.
Other
mechanisms
discussed.
Further
understanding
carcinogenic
properties
its
metabolites
will
inform
future
research,
but
there
already
a
need
for
comprehensive
control
prevention
strategies
reduce
burden
attributable
alcohol.
Biology,
Journal Year:
2023,
Volume and Issue:
12(7), P. 984 - 984
Published: July 11, 2023
Several
chronic
liver
diseases
are
characterized
by
a
clear
gender
disparity.
Among
them,
hepatocellular
carcinoma
(HCC)
shows
significantly
higher
incidence
rates
in
men
than
women.
The
different
epidemiological
distribution
of
risk
factors
for
disease
and
HCC
only
partially
accounts
these
differences.
In
fact,
the
is
an
organ
with
recognized
sexual
dysmorphism
extremely
sensitive
to
action
androgens
estrogens.
Sex
hormones
act
modulating
developing
influencing
its
aggressiveness,
response
treatments,
prognosis.
Furthermore,
estrogens
able
modulate
other
cofactors
damage
(e.g.,
HBV
infection,
obesity),
their
carcinogenic
power.
purpose
this
review
examine
related
as
well
pathophysiological
mechanisms
involved,
particular
reference
central
role
played
sex
hormones.
Gut,
Journal Year:
2023,
Volume and Issue:
72(10), P. 1942 - 1958
Published: Jan. 2, 2023
The
current
treatment
for
hepatocellular
carcinoma
(HCC)
to
block
angiogenesis
and
immunosuppression
provides
some
benefits
only
a
subset
of
patients
with
HCC,
thus
optimised
therapeutic
regimens
are
unmet
needs,
which
require
thorough
understanding
the
underlying
mechanisms
by
tumour
cells
orchestrate
an
inflamed
microenvironment
significant
myeloid
cell
infiltration.
MicroRNA-223
(miR-223)
is
highly
expressed
in
but
its
role
regulating
remains
unknown.
Molecular Therapy,
Journal Year:
2020,
Volume and Issue:
29(2), P. 680 - 690
Published: Oct. 23, 2020
Adeno-associated
virus
(AAV)
integrates
into
host
genomes
at
low
frequency,
but
when
integration
occurs
in
oncogenic
hotspots
it
can
cause
hepatocellular
carcinoma
(HCC).
Given
the
possibility
of
recombinant
AAV
(rAAV)
leading
to
HCC,
common
causes
liver
inflammation
like
non-alcoholic
fatty
disease
(NAFLD)
may
increase
risk
rAAV-induced
HCC.
A
rAAV
targeting
mouse
Rian
locus
was
used,
and
as
expected
led
HCC
all
mice
infected
neonates,
likely
due
growth-related
hepatocyte
proliferation
young
mice.
Mice
with
adults
did
not
develop
unless
they
were
fed
a
diet
NAFLD,
increased
proliferation.
Female
less
susceptible
male
NAFLD
treated
estrogen
exhibited
immune
exhaustion
associated
oncogenesis
compared
those
without
estrogen.
Adult
non-targeted
control
also
developed
though
only
half
frequently
exposed
targeted
rAAV.
This
study
shows
that
adult
gene
therapy
context
chronic
high
thus
warrants
further
humans
given
prevalence
population.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(7), P. 1076 - 1076
Published: July 5, 2021
Nonalcoholic
fatty
liver
diseases
(NAFLD)
represent
a
set
of
disorders
progressing
from
steatosis
to
steatohepatitis,
fibrosis,
cirrhosis,
and
hepatocellular
carcinoma,
which
induce
huge
burden
human
health.
Many
pathophysiological
factors
are
considered
influence
NAFLD
in
parallel
pattern,
involving
insulin
resistance,
oxidative
stress,
lipotoxicity,
mitochondrial
dysfunction,
endoplasmic
reticulum
inflammatory
cascades,
fibrogenic
reaction,
etc.
However,
the
underlying
mechanisms,
including
those
that
development,
have
not
been
fully
understood.
Specifically,
mainly
mediated
by
excessive
accumulation
reactive
oxygen
species,
has
participated
multiple
NAFLD-related
signaling
serving
as
an
accelerator.
Ameliorating
stress
maintaining
redox
homeostasis
may
be
promising
approach
for
management
NAFLD.
Green
tea
is
one
most
important
dietary
resources
natural
antioxidants,
above
epigallocatechin
gallate
(EGCG)
notably
contributes
its
antioxidative
action.
Accumulative
evidence
randomized
clinical
trials,
systematic
reviews,
meta-analysis
revealed
beneficial
functions
green
EGCG
preventing
managing
NAFLD,
with
acceptable
safety
patients.
Abundant
animal
cellular
studies
demonstrated
protect
against
initiation
development
alleviating
related
metabolism
inflammation,
tumorigenesis.
The
targeted
pathways
include,
but
limited
to,
NRF2,
AMPK,
SIRT1,
NF-κB,
TLR4/MYD88,
TGF-β/SMAD,
PI3K/Akt/FoxO1,
In
this
review,
we
thoroughly
discuss
stress-related
mechanisms
involved
well
summarize
protective
effects
