Key determinants of success in fecal microbiota transplantation: From microbiome to clinic

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(5), P. 712 - 733

Published: May 1, 2023

Language: Английский

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Gut microbiota and hypertension: association, mechanisms and treatment

Clinical and Experimental Hypertension, Journal Year: 2023, Volume and Issue: 45(1)

Published: March 30, 2023

Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular diseases, which brings a heavy economic burden to society and becomes major public health problem. At present, pathogenesis hypertension unclear. Increasing evidence has proven that closely related dysbiosis gut microbiota. We briefly reviewed relevant literature on microbiota summarize relationship between hypertension, linked antihypertension effects drugs with their modulation microbiota, discussed potential mechanisms various microbes active metabolites alleviate thus providing new research ideas development drugs.Methods The was collected systematically from scientific database, including Elsevier, PubMed, Web Science, China National Knowledge Infrastructure (CNKI), Baidu Scholar, as well other sources, such classic books herbal medicine.Results can lead imbalance barrier dysfunction, increased harmful bacteria hydrogen sulfide lipopolysaccharide, decreased beneficial short-chain fatty acids, intestinal tight junction proteins permeability. Gut occurrence hypertension. main methods regulate include fecal transplantation, supplementation probiotics, antibiotics, diet exercise, antihypertensive drugs, natural medicines.Conclusions Investigating correlation may help reveal perspective great significance prevention treatment

Language: Английский

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Gut microbiota modulation in patients with non-alcoholic fatty liver disease: Effects of current treatments and future strategies

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is frequently associated with metabolic disorders, being highly prevalent in obese and diabetic patients. Many concomitant factors that promote systemic inflammation are involved NAFLD pathogenesis, a growing body of evidence highlighting the key role gut microbiota. Indeed, gut-liver axis has strong impact promotion progression wide spectrum its manifestations, claiming efforts to find effective strategies for microbiota modulation. Diet among most powerful tools; Western diet negatively affects intestinal permeability composition function, selecting pathobionts, whereas Mediterranean fosters health-promoting bacteria, favorable on lipid glucose metabolism inflammation. Antibiotics probiotics have been used improve features, mixed results. More interestingly, medications treat NAFLD-associated comorbidities may also modulate Drugs treatment type 2 diabetes mellitus (T2DM), such as metformin, glucagon-like peptide-1 (GLP-1) agonists, sodium-glucose cotransporter (SGLT) inhibitors, not only regulation homeostasis, but reduction fat content inflammation, they shift towards healthy phenotype. Even bariatric surgery significantly changes microbiota, mostly due modification gastrointestinal anatomy, parallel improvement histological features NAFLD. Other options promising effects reprogramming axis, fecal microbial transplantation (FMT) next-generation deserve further investigation future inclusion therapeutic armamentarium

Language: Английский

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The Implication of the Gut Microbiome in Heart Failure

Cells, Journal Year: 2023, Volume and Issue: 12(8), P. 1158 - 1158

Published: April 14, 2023

Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well healthcare system. Over recent decades, numerous pieces evidence have demonstrated that associated gut microbiota represent an component human physiology and metabolic homeostasis, can affect one’s state or disease directly, through their derived metabolites. The advances in microbiome studies shed light on relationship between cardiovascular system, revealing its contribution to development heart failure-associated dysbiosis. HF has been linked dysbiosis, low bacterial diversity, intestinal overgrowth potentially pathogenic bacteria decrease short chain fatty acids-producing bacteria. An increased permeability allowing microbial translocation passage bacterial-derived metabolites into bloodstream progression. A more insightful understanding interactions microbiome, risk factors mandatory optimizing therapeutic strategies based modulation offering individualized treatment. purpose this review summarize available data regarding influence communities HF, order obtain better multi-layered complex relationship.

Language: Английский

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Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Cells, Journal Year: 2023, Volume and Issue: 12(14), P. 1888 - 1888

Published: July 19, 2023

The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules microorganisms. Bile acids are small synthesized cholesterol in liver, secreted into duodenum, transformed to secondary or tertiary bile by gut microbiota. interact with acid receptors (BARs) microbiota, which plays key role maintaining homeostasis barrier. In this review, we summarize discuss recent studies on disorder associated dysfunction related diseases. We focus roles acids, BARs, microbiota triggering dysfunction. Insights for future prevention treatment diseases provided.

Language: Английский

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Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

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Gut microbiota and intestinal immunity—A crosstalk in irritable bowel syndrome

Immunology, Journal Year: 2024, Volume and Issue: 172(1), P. 1 - 20

Published: Jan. 4, 2024

Irritable bowel syndrome (IBS), one of the most prevalent functional gastrointestinal disorders, is characterized by recurrent abdominal pain and abnormal defecation habits, resulting in a severe healthcare burden worldwide. The pathophysiological mechanisms IBS are multi-factorially involved, including food antigens, visceral hypersensitivity reactions, brain–gut axis. Numerous studies have found that gut microbiota intestinal mucosal immunity play an important role development crosstalk with multiple mechanisms. Therefore, based on existing evidence, this paper elaborates damage activation disturbance closely related to progression IBS. Combined application prospect, it also provides references for further in-depth exploration clinical practice.

Language: Английский

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The emerging role of the gut microbiota and its application in inflammatory bowel disease

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

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Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 434 - 434

Published: Feb. 17, 2022

Conventional drug administration usually faces the problems of degradation and rapid excretion when crossing many biological barriers, leading to only a small amount drugs arriving at pathological sites. Therapeutic delivered by delivery systems target sites in controlled manner greatly enhance efficacy, bioavailability, pharmacokinetics with minimal side effects. Due distinct advantages microfluidic techniques, setups provide powerful tool for synthesis systems, precisely release, real-time observation desired location rate. In this review, we present an overview recent advances preparation nano carrier-free as well construction vitro models on-a-chip efficiency evaluation systems. We firstly introduce including liposomes, polymers, inorganic compounds, followed detailed descriptions system, micro-reservoir microneedle Finally, discuss developed on devices such blood-brain barrier model, vascular intestine so on. The opportunities challenges applications platforms their clinical applications, are also discussed.

Language: Английский

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Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(6), P. 1635 - 1646

Published: July 4, 2023

The intestinal mucosa represents the most extensive human barrier having a defense function against microbial and food antigens. This is represented externally by mucus layer, consisting mainly of mucins, antimicrobial peptides, secretory immunoglobulin A (sIgA), which serves as first interaction with microbiota. Below placed epithelial monolayer, comprising enterocytes specialized cells, such goblet Paneth enterochromaffin others, each specific protective, endocrine, or immune function. layer interacts both luminal environment underlying lamina propria, where mucosal immunity processes primarily take place. Specifically, between microbiota an intact results in activation tolerogenic processes, mediated FOXP3+ regulatory T homeostasis. Conversely, impairment function, alteration normal composition (dysbiosis), imbalance pro- anti-inflammatory factors may result inflammation disease. Another crucial component gut-vascular barrier, formed endothelial pericytes, glial regulates passage molecules into bloodstream. aim this review to examine various components assessing their system, focus on immunological homeostasis inflammation.

Language: Английский

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