Effect of norethisterone dose and duration in the management of abnormal uterine bleeding: a narrative review and case report

Drugs in Context, Journal Year: 2024, Volume and Issue: 13, P. 1 - 19

Published: July 2, 2024

Abnormal uterine bleeding (AUB) is an acute/chronic variation in the normal menstrual cycle that affects adolescents, women of reproductive age and perimenopausal women. AUB approximately 3-30% reproductive-aged worldwide, reduces their quality life productivity whilst increasing overall healthcare burden. Its management requires thorough medical evaluation individualized treatment. Depending on severity cause AUB, its treatment ranges from lifestyle modifications hormonal therapies to more invasive procedures or surgery. Although therapy preferred first-line measure available pharmacological options have various adverse effects. There exists a need for safer efficient regimens with high patient compliance effectively treat AUB. Norethisterone, also known as norethindrone, widely used synthetic analogue progestogen. Controlled release formulations norethisterone/ norethisterone acetate help maintain constant drug levels blood exert minimal side-effects; therefore, they are promising therapeutic agents effective management. The present review summarizes epidemiology diagnosis focus safety, efficacy tolerability We report case 40-year-old woman, who was treated NETA tablets. resulted favourable outcomes, satisfaction.

Language: Английский

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Evidence gaps for the global problem of iron deficiency and iron deficiency anemia in women and girls of reproductive age

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 89 - 92

Published: Aug. 1, 2023

Abstract The symptom of heavy menstrual bleeding and the frequently associated condition iron deficiency (ID) individually collectively adversely impact lives women girls reproductive age in various ways. insidious but sometimes profound effects periconceptual ID on developing fetus may continue throughout individual's life with consequences that are also felt by families, friends, society at large. Unfortunately, most instances, current healthcare policies not designed to address plethora issues a fashion will result meaningful improvement health other outcomes affect both individuals society. Identification prioritization many evidence gaps be an essential component strategy for change. This article identifies describes provides direction investigators those involved policy.

Language: Английский

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Conservative treatment for retained gestational tissue following miscarriage or abortion

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(1), P. 8 - 9

Published: Jan. 1, 2024

Language: Английский

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Heavy uterine bleeding in women with endometriosis and adenomyosis treated with dienogest

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(2), P. 139 - 140

Published: March 1, 2024

Language: Английский

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The impact of gonadotropin-releasing hormone agonist and hormone replacement therapy in placement of hormone replacement therapy on outcomes of IVF after hysteroscopic polypectomy

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(2), P. 146 - 148

Published: March 1, 2024

Language: Английский

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A comparative retrospective analysis on robot-assisted laparoscopic surgery compared to conventional laparoscopy in case of myomectomy: experience in a third-level hospital of Southern Italy

Updates in Surgery, Journal Year: 2024, Volume and Issue: 76(6), P. 2371 - 2378

Published: April 30, 2024

Abstract Uterine myomas are the most common gynecological disease in reproductive-aged women, present several symptoms, and require effective medical and/or surgical strategies. This study aimed to compare robotic-assisted laparoscopic myomectomy (RALM) with (LM) terms of operative times, intraoperative estimated blood loss, pre- post-hemoglobin levels drop, length hospital stay. Data from 50 clinical records (25 RALM Group A 25 LM B) patients uterine fibroids were collected December 2022 2023 at Gynecological Unit DAI Materno-Infantile Federico II Naples, Italy. Patients aged 30–49 years symptomatic included. on peri-operative outcomes, including time for (OTM), overall (OOT), loss (EBL), post-operative hemoglobin levels, stay analyzed. The OTM presence > 5 was 59 [52–65] vs 69 min [61–96] ( p < 0.001) groups, respectively. Moreover, also ≤ myomas, a difference observed group 48[43–55] compared 53[50–61] = 0.07). OOT statistically significant B (83[65–93] 72[56–110] min, 0.001). There no differences between two groups EBL 0.178). demonstrated notably shorter 1.2 [1–2] days 2.9[3–3.75] 0.007). Our suggests potential advantages over reduced times stays. standardized approach extensive experience likely contributed favorable outcomes RALM.

Language: Английский

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Taohong siwu decoction ameliorates abnormal uterine bleeding via inhibiting ACSL4-mediated ferroptosis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119130 - 119130

Published: Nov. 1, 2024

Language: Английский

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Advancements in Minimally Invasive Techniques and Biomarkers for the Early Detection of Endometrial Cancer: A Comprehensive Review of Novel Diagnostic Approaches and Clinical Implications

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7538 - 7538

Published: Dec. 11, 2024

This review evaluates the advances in early detection and diagnosis of endometrial cancer (EC), emphasizing growing importance minimally invasive techniques novel biomarkers. Current diagnostic protocols for EC rely heavily on procedures such as transvaginal ultrasound (TVU), hysteroscopy, biopsy, which, although effective, can be overly burdensome patients inefficient asymptomatic or low-risk populations. As there is no consensus screening high-risk general populations, recent studies have explored alternative methods using biofluids genomic biomarkers to improve sensitivity specificity facilitate access patients. summarizes findings DNA methylation markers, circulating tumor-derived nucleic acids, potential liquid biopsy approaches EC. These innovations may not only streamline but also reduce need procedures. highlights these integrated seamlessly into existing cervical programs, which could transform support development personalized, less

Language: Английский

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Our path from abnormal uterine bleeding and iron deficiency to impaired fetal development: A long and winding road

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 3 - 6

Published: Aug. 1, 2023

Language: Английский

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STATISTICAL ANALYSIS OF ABNORMAL UTERINE BLEEDING AMONG MALDIVIAN WOMEN OF REPRODUCTIVE AGE

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(2)

Published: Feb. 25, 2024

Introduction. Abnormal uterine bleeding (AUB) describes that varies from the usual parameters of a normal menstrual cycle [3]. AUB is one most common gynecologic problems among women reproductive age. Approximately one-third experience at some point in their lives [1]. Purpose study. This study aims to explore prevalence and causes Maldivian age who have experienced menstruation. Materials method. An online questionnaire survey was conducted reproductive-age Maldivians The population analyzed through exploratory data analysis. Research result. From collected, out 110 participants, 37 (33.6%) individuals reported having irregular menses. Additionally, 22 (20%) menorrhagia. Moreover, 16 (14.5%) polymenorrhea, 14 (12.7%) amenorrhea 9 (8.2%) oligomenorrhea. According interpreted pictogram, it observed 35 participants self-reporting heavy bleeding, merely 20% (7 individuals) actually had blood loss (MBL) exceeding 80ml. average these calculated be 113 ml, highlighting notable disparity between subjective perception objective data. Out 68 flow, 4 MBL 80ml, with mean 116.19 ml. entire group, 44 (40%) diagnosis polycystic ovarian syndrome (PCOS), 18 (16.4%) cysts. Furthermore, 2 (1.8%) endometriosis, fibroids and, mentioned cervical polyp, 1 (0.9%) an endometrial polyp. Conclusion. Using FIGO system as gateway simplifies process investigating [2]. Based on criteria set by 1, only 46 (41.8%) were found cycle. remaining 64 (58.2%) AUB. total 29 PCOS. These findings suggest significant association PCOS within population.

Language: Английский

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