Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

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A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(29), P. 12181 - 12188

Published: July 8, 2024

New strategies for the simultaneous and portable detection of multiple enzyme activities are highly desirable clinical diagnosis home care. However, methods developed thus far generally suffer from high costs, cumbersome procedures, heavy reliance on large-scale instruments. To satisfy actual requirements rapid, accurate, on-site activities, we report herein a smartphone-assisted programmable microfluidic paper-based analytical device (μPAD) that utilizes colorimetric photothermal signals simultaneous, visual quantitative alkaline phosphatase (ALP) butyrylcholinesterase (BChE). Specifically, operation this μPAD sensing platform is based two sequential steps. Cobalt-doped mesoporous cerium oxide (Co-m-CeO

Language: Английский

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NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 8, 2024

Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.

Language: Английский

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Dual-mode photothermal/chemiluminescence vertical flow assay for sensitive point-of-care detection of carcinoembryonic antigen using Cu2-xAgxS@liposome on a filter membrane

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116602 - 116602

Published: July 23, 2024

Language: Английский

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Regulating the redox and non-redox enzyme-mimicking activities of Ce-UiO-66-NO2 nanozyme for dual-mode sensing of phosphate

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135782 - 135782

Published: April 9, 2024

Language: Английский

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Ligand density-optimized peroxidase-like activity of gold nanoclusters for colorimetric sensing of biothiols and acetylcholinesterase

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 417, P. 136069 - 136069

Published: June 4, 2024

Language: Английский

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Self-sacrificing-induced defect enhances the oxidase-like activity of MnOOH for total antioxidant capacity evaluation

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1308, P. 342664 - 342664

Published: April 29, 2024

Language: Английский

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A Smartphone-enabled Colorimetric Sensing Platform Based on Au-decorated Fe3O4 Nanoparticles as Nanozyme for Dual-mode Visual Monitoring of Dopamine Hydrochloride

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 104221 - 104221

Published: April 27, 2024

Language: Английский

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Integration of PG and NMM as a universal unlabeled, enzyme-free, luminescent-nanomaterial-free and catalysis-free dual-output system for versatile concurrent DNA logic computing and ratiometric fluorescent sensing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159278 - 159278

Published: Jan. 1, 2025

Language: Английский

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Nanozyme-Energized SERS Sensor for Ultrasensitive Dual-Mode Bacterial Detection

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

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