Brazilian Journal of Medical and Biological Research,
Journal Year:
2024,
Volume and Issue:
57
Published: Jan. 1, 2024
Renal
fibrosis
is
a
common
manifestation
in
the
progression
of
chronic
kidney
disease
(CKD)
to
failure.
Currently,
there
no
available
therapy
prevent
renal
fibrosis.
Poricoic
acid
A
(PAA)
isolated
from
Poria
cocos
shows
notable
antifibrotic
effects.
However,
its
potential
mechanism
still
unclear.
This
study
aimed
evaluate
effects
and
mechanisms
PAA
against
mouse
model
was
established
using
unilateral
ureteral
obstruction
(UUO).
We
showed
that
administration
significantly
alleviated
lesions
collagen
deposition
UUO
mice.
Mice
with
resulted
epithelial-to-mesenchymal
transition
(EMT)
activation
endoplasmic
reticulum
stress
(ERS)
tissues,
while
treatment
inhibited
EMT
ERS
activation.
Additionally,
markedly
ERS-mediated
apoptosis
Molecular
docking
results
indicated
stably
combined
GRP78
ATF4.
In
conclusion,
these
demonstrated
possesses
significant
bioactivity
might
be
inhibition
apoptosis.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 2, 2025
Chronic
kidney
disease
(CKD)
stands
as
a
formidable
global
health
challenge,
often
advancing
to
end-stage
renal
(ESRD)
with
devastating
morbidity
and
mortality.
At
the
central
of
this
progression
lies
podocyte
injury,
critical
determinant
glomerular
dysfunction.
Compound
K
(CK),
bioactive
metabolite
derived
from
ginsenoside,
has
emerged
compelling
candidate
for
nephroprotective
therapy.
Here,
we
unveil
profound
therapeutic
potential
CK
in
folic
acid
(FA)-induced
CKD
mouse
model,
demonstrating
its
ability
restore
function
mitigate
injury.
exerted
effects
by
reinforcing
inter-podocyte
junctions,
suppressing
aberrant
motility,
preventing
detachment
apoptosis,
thereby
safeguarding
filtration
barrier.
Mechanistically,
identified
mitochondrial
dysregulation
key
driver
excessive
oxidative
stress,
which
is
commonly
associated
damage.
remarkably
restored
homeostasis
attenuating
pathological
fission
enhancing
mitophagy,
rebalancing
delicate
network.
Intriguingly,
may
disrupt
formation
Drp1-Bax
dimer,
crucial
mediator
further
averting
loss.
Collectively,
our
findings
highlight
potent
agent,
offering
novel
avenue
management
redefining
possibilities
battle
against
progressive
disease.
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 29, 2024
Mitochondria
are
energy
factories
that
sustain
life
activities
in
the
body,
and
their
dysfunction
can
cause
various
metabolic
diseases
threaten
human
health.
Mitophagy,
an
essential
intracellular
mitochondrial
quality
control
mechanism,
maintain
cellular
homeostasis
by
removing
damaged
mitochondria
participating
developing
diseases.
Research
has
confirmed
exercise
regulate
mitophagy
levels,
thereby
exerting
protective
effects
This
article
reviews
role
of
diseases,
on
mitophagy,
potential
mechanisms
exercise-regulated
intervention
providing
new
insights
for
future
basic
clinical
research
interventions
to
prevent
treat
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 3, 2025
The
Latin
name
of
Wolfiporia
cocos
is
(F.A.
Wolf)
Ryvarden
&
Gilb,
it
a
medicinal
and
edible
mushroom
belonging
to
the
family
Polyporaceae.
Traditional
Chinese
medicine
believes
that
can
strengthen
spleen,
diuretic,
tranquillise
mind
dispel
dampness.
So
far,
chemical
active
metabolites
isolated
extracted
from
are
mainly
polysaccharides,
triterpenoids,
sterols.
Modern
pharmacology
has
found
these
have
wide
range
pharmacological
effects,
including
antitumour,
antioxidation,
anti-inflammatory,
immunomodulation,
regulation
intestinal
flora,
glycolipid
metabolism,
improvement
organ
function.
By
applying
Poria
,
cocos,
Gilb
as
search
terms,
we
searched
all
relevant
studies
on
Web
Science
PubMed
databases
classified
categories
according
main
research
content
each
literature
summarized
its
mechanism
action,
updated
latest
results,
discussed
direction
further
in
future
provide
better
reference
for
clinical
applications
with
therapeutic
effects
potential
value.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 4, 2025
Microvascular
complications
of
diabetes
pose
a
significant
threat
to
global
health,
mainly
including
diabetic
kidney
disease
(DKD),
retinopathy
(DR),
peripheral
neuropathy
(DPN),
and
cardiomyopathy
(DCM),
which
can
ultimately
lead
failure,
blindness,
disability,
heart
failure.
With
the
increasing
prevalence
diabetes,
search
for
new
therapeutic
targets
microvascular
is
imminent.
Mitophagy
widespread
strictly
maintained
process
self-renewal
energy
metabolism
that
plays
an
important
role
in
reducing
inflammatory
responses,
inhibiting
reactive
oxygen
species
accumulation,
maintaining
cellular
metabolism.
Hyperglycemia
results
impaired
mitophagy,
leads
mitochondrial
dysfunction
exacerbates
progression.
This
article
summarizes
relevant
molecular
mechanisms
mitophagy
reviews
current
status
research
on
regulating
as
potential
treatment
complications,
attempting
give
angles
complications.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 9, 2024
This
article
reviews
the
latest
research
progress
on
role
of
mitochondrial
autophagy
receptor
FUN14
domain
containing
1
(FUNDC1)
in
events
and
kidney
disease.
FUNDC1
is
a
protein
located
outer
membrane
mitochondria,
which
maintains
function
quality
mitochondria
by
regulating
autophagy,
that
is,
selective
degradation
process
mitochondria.
The
structural
characteristics
enable
it
to
respond
intracellular
signal
changes
regulate
activity
through
phosphorylation
dephosphorylation.
During
phosphorylation,
unc-51-like
kinase
(ULK1)
promotes
activation
mitophagy
phosphorylating
Ser17
FUNDC1.
In
contrast,
Src
CK2
kinases
inhibit
interaction
between
LC3
Tyr18
Ser13,
thereby
inhibiting
mitophagy.
dephosphorylation,
PGAM5
phosphatase
enhances
dephosphorylating
activating
BCL2L1
inhibits
interacting
with
PGAM5,
preventing
dephosphorylation
plays
an
important
events,
participating
fission,
maintaining
homeostasis
iron
proteins
matrix,
mediating
crosstalk
endoplasmic
reticulum
lysosomes,
have
effects
cell
energy
metabolism
programmed
death.
aspect
disease,
abnormal
closely
related
occurrence
development
many
diseases.
acute
injury
(AKI),
cardiorenal
syndrome
(CRS),
diabetic
nephropathy
(DN),
chronic
disease
(CKD)
,renal
fibrosis
(RF)
renal
anemia,
FUNDC1-mediated
imbalance
may
be
one
key
factors
progression.
Therefore,
in-depth
study
regulatory
mechanism
great
significance
for
understanding
pathogenesis
developing
new
treatment
strategies.
