Sarcopenia definition, diagnosis and treatment: consensus is growing

Age and Ageing, Journal Year: 2022, Volume and Issue: 51(10)

Published: Oct. 1, 2022

Abstract Sarcopenia is a skeletal muscle disorder that commonly occurs with advancing age as well number of long-term conditions. Recognition in clinical practice relatively recent but important because the association between sarcopenia and range adverse effects on health including impaired mobility, increased morbidity mortality. Originally characterised loss mass, definition has evolved to focus function, particularly strength, through international definitions such European Working Group Older People most recently revised 2019. Progress decades ahead likely be seen regard use routine data, prescription resistance exercise, translation biology epidemiology into first man studies for new treatments, low middle-income countries. Immediate next steps include newly formed Global Leadership Initiative develop consensus diagnosis.

Language: Английский

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Sarcopenia

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 19, 2024

Language: Английский

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The beneficial therapeutic effects of plant‐derived natural products for the treatment of sarcopenia

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(6), P. 2772 - 2790

Published: Aug. 12, 2022

Abstract Sarcopenia is an age‐related muscle disorder typically associated with a poor quality of life. Its definition has evolved over time, and several underlying causes sarcopenia in the elderly have been proposed. However, exact mechanisms involved sarcopenia, as well effective treatments for this condition, are not fully understood. The purpose article was to conduct comprehensive review previous evidence regarding definition, diagnosis, risk factors, efficacy plant‐derived natural products sarcopenia. methodological approach current narrative performed using PubMed, Scopus, Web Science databases, Google Scholar (up March 2021) order satisfy our objectives. substantial beneficial effects along safety some including curcumin, resveratrol, catechin, soy protein, ginseng on reported review. Based clinical studies, nutraceuticals functional foods may physical performance, handgrip knee‐extension strength, weight‐lifting capacity, time or distance travelled before feeling fatigued, mitochondrial function, fatigue, mean fibre area, total number myonuclei. In preclinical supplementation herbs bioactive compounds resulted increased plantaris mass, skeletal mass strength production, expression anabolic factors myogenin, Myf5 MyoD, enhanced inhibition atrophy We found that such nutritional status, inactivity, inflammation, oxidative stress, endocrine system dysfunction, insulin resistance, history chronic disease, mental health, genetic linked ginseng, without any significant side effects, Plant‐derived might effect various components Nevertheless, due limited human trials, benefits remain inconclusive. It suggested longitudinal studies better understand identifying treatment strategy based its pathophysiology, be undertaken future investigations.

Language: Английский

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Coffee or tea: Anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106596 - 106596

Published: Dec. 5, 2022

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation and its biomarkers, like C-reactive protein (CRP), among risk factors, such as hypertension, lipid disorders, diabetes, may be also responsible for residual (CVD) risk. Modern lipid-lowering treatment with statins, ezetimibe, PCSK9 inhibitors, or bempedoic acid does not fully protect against inflammation. The recommendations International Lipid Expert Panel (ILEP) indicate selected nutraceuticals anti-inflammatory properties. Diet have a significant impact on Especially interesting in context inflammation consumption coffee tea. These drinks many observational studies significantly reduced mortality. question whether effects these contribute to observed clinical effects. Thus, this narrative review, we primarily discuss properties consuming tea coffee. Based comprehensive analysis their meta-analyses, inconsistent results were obtained, which makes it impossible conclusively state how clinically potential black green are. A number confounding factors can inconsistency available results. Consumption appears increase adiponectin concentrations, decrease reactive oxygen species, low density lipoprotein (LDL) cholesterol concentrations (effect tea, etc.). Despite still uncertain effect coffee, recommend part healthy diet.

Language: Английский

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An Integrated Approach to Skeletal Muscle Health in Aging

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1802 - 1802

Published: April 7, 2023

A decline in muscle mass and function represents one of the most problematic changes associated with aging, has dramatic effects on autonomy quality life. Several factors contribute to inexorable process sarcopenia, such as mitochondrial autophagy dysfunction, lack regeneration capacity satellite cells. The physiologic motoneuron functionality aging is exacerbated by sedentary lifestyle that accompanies elderly people. Regular physical activity beneficial people, but need well-designed carefully administered training programs improve and, consequently, both functional ability Aging also causes alteration gut microbiota composition some advances research have elucidated interventions via microbiota–muscle axis potential ameliorate sarcopenic phenotype. mechanisms are involved vitamin D atrophy protection, demonstrated decreased muscular related deficiency. Malnutrition, chronic inflammation, deficiencies, an imbalance muscle–gut just a few can lead sarcopenia. Supplementing diet antioxidants, polyunsaturated fatty acids, vitamins, probiotics, prebiotics, proteins, kefir, short-chain acids could be nutritional therapies against Finally, personalized integrated strategy counteract sarcopenia maintain health skeletal muscles suggested this review.

Language: Английский

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Pathogenesis, Intervention, and Current Status of Drug Development for Sarcopenia: A Review

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1635 - 1635

Published: June 4, 2023

Sarcopenia refers to the loss of muscle strength and mass in older individuals is a major determinant fall risk impaired ability perform activities daily living, often leading disability, independence, death. Owing its impact on morbidity, mortality, healthcare expenditure, sarcopenia elderly has become focus research public policy debates worldwide. Despite clinical importance, remains under-recognized poorly managed routine practice, partly owing lack available diagnostic testing uniform criteria. Since World Health Organization United States assigned disease code for 2016, countries worldwide have their own codes sarcopenia. However, there are currently no approved pharmacological agents treatment sarcopenia; therefore, interventions primarily physical therapy strengthening gait training as well adequate protein intake. In this review, we aimed examine latest information epidemiology, molecular mechanisms, interventions, possible treatments with new drugs

Language: Английский

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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(4), P. 301 - 324

Published: April 1, 2024

Language: Английский

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Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107054 - 107054

Published: Jan. 4, 2024

Diabetes, characterized as a well-known chronic metabolic syndrome, with its associated complications pose substantial and escalating health healthcare challenge on global scale. Current strategies addressing diabetes are mainly symptomatic there fewer available curative pharmaceuticals for diabetic complications. Thus, is an urgent need to identify novel pharmacological targets agents. The impaired mitochondria have been the etiology of complications, intervention mitochondrial dysfunction represents attractive breakthrough point treatments Natural products (NPs), multicenter characteristics, multi-pharmacological activities lower toxicity, caught attentions modulators functions in therapeutical filed This review summarizes recent progresses potential 39 NPs 2 plant-extracted mixtures improve against It expected that this work may be useful accelerate development innovative drugs originated from upcoming therapeutics

Language: Английский

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Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4534 - 4534

Published: Feb. 25, 2023

Frailty is a global health problem that impacts clinical practice. It complex, having physical and cognitive component, it the result of many contributing factors. Frail patients have oxidative stress elevated proinflammatory cytokines. impairs systems results in reduced physiological reserve increased vulnerability to stress. related aging cardiovascular diseases (CVD). There are few studies on genetic factors frailty, but epigenetic clocks determine age frailty. In contrast, there overlap frailty with disease its risk not yet considered factor for CVD. accompanied by loss and/or poor functioning muscle mass, which depends fiber protein content, resulting from balance between breakdown synthesis. Bone fragility also implied, crosstalk adipocytes, myocytes, bone. The identification assessment difficult, without being standard instrument identify or treat it. Measures prevent progression include exercises, as well supplementing diet vitamin D K, calcium, testosterone. conclusion, more research needed better understand avoid complications

Language: Английский

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