Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 2554 - 2559
Published: Jan. 1, 2025
Language: Английский
Metabolism, Journal Year: 2023, Volume and Issue: 146, P. 155637 - 155637
Published: June 21, 2023
Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.
Language: Английский
Citations
46
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1204 - 1236
Published: March 14, 2024
Diabetes represents a major public health concern with considerable impact on human life and healthcare expenditures. It is now well established that diabetes characterized by severe skeletal muscle pathology limits functional capacity quality of life. Increasing evidence indicates also one the most prevalent disorders impaired regeneration, yet underlying mechanisms therapeutic treatments remain poorly established. In this review, we describe cellular molecular alterations currently known to occur during regeneration in people animal models diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, insulin resistance. We role myogenic non-myogenic cell types conditions or without diabetes. Therapies for gaps our knowledge are discussed, while proposing future directions field.
Language: Английский
Citations
24
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 30 - 44
Published: Nov. 22, 2022
Abstract Probiotics have shown potential to counteract sarcopenia, although the extent which they can influence domains of sarcopenia such as muscle mass and strength in humans is unclear. The aim this systematic review meta‐analysis was explore impact probiotic supplementation on mass, total lean human adults. A literature search randomized controlled trials (RCTs) conducted through PubMed, Scopus, Web Science Cochrane Library from inception until June 2022. Eligible RCTs compared effect versus placebo global (composite score all outcomes) adults (>18 years). To evaluate differences between groups, a using random effects inverse‐variance model by utilizing standardized mean differences. Twenty‐four studies were included exploring probiotics strength. Our main analysis ( k = 10) revealed that improved following with (SMD: 0.42, 95% CI: 0.10–0.74, I 2 57%, P 0.009), no changes relation 12; SMD: ‐0.03, −0.19 – 0.13, 0%, 0.69). Interestingly, significant increase also observed among six 0.69, 0.33–1.06, 64%, 0.0002). Probiotic enhances both strength; however, beneficial mass. Investigating physiological mechanisms underpinning different ageing groups elucidating appropriate strains for optimal gains are warranted.
Language: Английский
Citations
50
Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)
Published: March 6, 2024
Age-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal the pathophysiology of aging associated with phenotype. Diet is a major determinant gut-microbiota throughout entire lifespan, several benefits healthy diet could be mediated by microbiome. Mediterranean (MD) traditional dietary pattern regarded paradigm, large number studies have demonstrated its promoting aging. MD has also positive modulatory effect on microbiome, favoring bacterial taxa involved synthesis bioactive compounds, such short-chain fatty acids (SCFAs), that counteract inflammation, anabolic resistance, tissue degeneration. Intervention conducted older populations suggested individual response subjects to MD, terms reduction frailty scores amelioration cognitive function, significantly functionality. In this context, should considered when designing MD-based interventions tailored needs geriatric patients.
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5561 - 5561
Published: May 20, 2024
This review scrutinizes the intricate interplay between microbiome and human body, exploring its multifaceted dimensions far-reaching implications. The microbiome, comprising diverse microbial communities inhabiting various anatomical niches, is increasingly recognized as a critical determinant of health disease. Through an extensive examination current research, this elucidates dynamic interactions host physiology across multiple organ systems. Key topics include establishment maintenance microbiota diversity, influence factors on composition, bidirectional communication pathways cells. Furthermore, we delve into functional implications dysbiosis in disease states, emphasizing role shaping immune responses, metabolic processes, neurological functions. Additionally, discusses emerging therapeutic strategies aimed at modulating to restore host–microbe homeostasis promote health. Microbiota fecal transplantation represents groundbreaking approach management dysbiosis-related diseases, offering promising avenue for restoring balance within gut ecosystem. innovative therapy involves transfer from healthy donor individual suffering dysbiosis, aiming replenish beneficial populations mitigate pathological imbalances. By synthesizing findings fields, offers valuable insights complex relationship highlighting avenues future research clinical interventions.
Language: Английский
Citations
12
The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(3), P. 100171 - 100171
Published: Feb. 28, 2024
Diets rich in live microbes can bring various health benefits. However, the association between dietary microbe intake and frailty has not been studied. The study utilized data from National Health Nutrition Examination Survey (NHANES) 2007–2018. A total of 11,529 participants were included. Sanders et al. classified level foods into low (<104 CFU/g), medium (104–107 or high (>107 CFU/g). With methodology questionnaire data, divided three groups: (1) group (only low-level foods), (2) (medium but high-level (3) (any foods). Additionally, with content aggravated as MedHi. Frailty index ≥0.25 is defined frailty. weighted logistic regression analysis was conducted to examine relationship restricted cubic splines (RCS) employed detect nonlinear relationships. In fully adjusted model, had a significantly lower risk than those (OR = 0.67, 95% CI: 0.56, 0.79). For every 100 grams MedHi food consumed, decreased by 11% 0.89, 0.85, 0.92) after adjusting all covariates. RCS indicated existence non-linear who consumed less MedHi, increasing may reduce frailty, exceeding grams, curve gradually levels off. Our results suggested that associated more research needed verify this.
Language: Английский
Citations
11
Calcified Tissue International, Journal Year: 2024, Volume and Issue: 114(6), P. 583 - 591
Published: April 20, 2024
Language: Английский
Citations
10
Food Control, Journal Year: 2024, Volume and Issue: 168, P. 110834 - 110834
Published: Aug. 27, 2024
Language: Английский
Citations
9
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 28, 2025
Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding mechanistic role gut microbiota-muscle cross-talk sarcopenia, therapeutic implications. The insights encompass causal dysbiosis potentially mediated through microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, their associated signaling pathways, which may be translated into development new microbiome-based treatment diagnostic approaches. Furthermore, identify challenges need addressing future studies to facilitate translation potential novel differential diagnosis older individuals
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 690 - 690
Published: Feb. 14, 2025
Background/Objectives: Gut microbiome modulation through probiotics is a growing area of research, with several investigations reporting beneficial health outcomes for the host. Physical exercise has been shown to impact gut diversity. Emerging evidence suggests that probiotic supplementation can affect performance. However, mechanisms and domain-specific effects on performance remain be elucidated. This narrative review aims investigate potential underpinning ergogenic benefits further define current base specific domains. Discussion: The literature improved recovery after intense training regimes, enhanced nutrient absorption, alleviation gastrointestinal symptoms, immune function may underpin sporting A small number trials also suggest improve symptoms anxiety. research warranted this topic. most substantial improvements in endurance performance, whilst only few have investigated upon power albeit promising results. Conclusions/Future Perspectives: In summary, performance; future wish explore action.
Language: Английский
Citations
1