Fecal microbiota transplantation for glaucoma; a potential emerging treatment strategy DOI Creative Commons
Rasoul Ebrahimi, Yeganeh Farsi, Seyed Aria Nejadghaderi

et al.

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 7, P. 100314 - 100314

Published: Jan. 1, 2024

Glaucoma is the primary cause of irreversible blindness globally. Different glaucoma subtypes are identified by their underlying mechanisms, and treatment options differ its pathogenesis. Current management includes topical medications to lower intraocular pressure surgical procedures like trabeculoplasty drainage implants. Fecal microbiota transplantation (FMT) an almost effective safe option for recurrent Clostridium difficile infection. The relationship between bacterial populations, metabolites, inflammatory pathways in retinal diseases indicates possible therapeutic strategies. Thus, incorporating host microbiota-based therapies could offer additional patients. Here, we propose that combining FMT with standard treatments may benefit those affected this condition. Also, potential safety, efficacy, cost-effectiveness clinical applications discussed.

Language: Английский

Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

4
Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials DOI Open Access
Bo Ma, Muttiah Barathan, Min Hwei Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

Citations

2
Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

13
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Yusheng Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

10
Full-length 16S rRNA-based exploration of body site-specific bacterial signatures for origin determination and individual identification DOI
Yinlei Lei,

Yu Hang Deng,

Ruocheng Xia

et al.

Forensic Science International, Journal Year: 2025, Volume and Issue: 371, P. 112475 - 112475

Published: April 19, 2025

Language: Английский

Citations

0
KNDM: A Knowledge Graph Transformer and Node Category Sensitive Contrastive Learning Model for Drug and Microbe Association Prediction DOI
Dongliang Chen, Tiangang Zhang, Hui Cui

et al.

Journal of Chemical Information and Modeling, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

It has been proven that the microbiome in human bodies can promote or inhibit treatment effects of drugs by affecting their toxicities and activities. Therefore, identifying drug-related microbes helps understanding how exert functions under influence these microbes. Most recent methods for microbe prediction are developed based on graph learning. However, those fail to fully utilize diverse characteristics drug entities from perspective a knowledge graph, as well contextual relationships among multiple meta-paths meta-path perspective. Moreover, previous overlook consistency between entity features derived node semantic extracted meta-paths. To address limitations, we propose knowledge-graph transformer category-sensitive contrastive learning-based association model (KNDM). This learns entities, encodes across meta-paths, integrates feature consistency. First, construct consisting which aids revealing similarities associations any two entities. Second, considering heterogeneity an integrate diversity types various them. Third, constructed capture embed nodes. A learning strategy with recursive gating is proposed specific individual while fusing Finally, develop node-category-sensitive enhance features. Extensive experiments demonstrate KNDM outperforms eight state-of-the-art drug-microbe models, ablation studies validate effectiveness its key innovations. Additionally, case candidate associated three drugs-curcumin, epigallocatechin gallate, ciprofloxacin-further showcase KNDM's capability identify potential associations.

Language: Английский

Citations

0
Comparative Changes in Fecal Microbiome After Endoscopic Resection and Surgical Resection in Gastric Cancer Patients DOI Open Access

Hochan Seo,

Jae Yong Park, Hee Sang You

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 144 - 144

Published: April 4, 2025

Background/Objectives: Gastric cancer treatments can lead to significant alterations patients’ gastrointestinal microbiome. However, differences in microbial impacts between gastrectomy and endoscopic submucosal dissection (ESD) remain underexplored. This study investigates how these influence diversity composition patients with stage I gastric cancer. Methods: Patients pathologically confirmed were recruited from Chung-Ang University Hospital December 2016 2019. analyzed fecal samples 13 (ESD: n = 5; gastrectomy: 8) before after treatment using 16S rRNA gene sequencing. Microbial indices taxonomic compared, follow-up extending up two years. Results: In the total cohort, alpha significantly decreased post-treatment (p < 0.05), beta analysis showed distinct clustering pre- 0.05). At genus level, Bacteroides while Lactobacillus, Bifidobacterium, Blautia increases Comparative analyses revealed that ESD group, remained unchanged, although without notable changes major taxa. contrast, surgical resection resulted a reduction 0.05) increased abundances of Streptococcus abundance Conclusions: Surgical exerts effects on microbiome composition, has more limited impact. These findings underscore importance considering postoperative management.

Language: Английский

Citations

0
Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review DOI Creative Commons
Angeliki Kontou, Eleni Agakidou, Ilias Chatziioannidis

et al.

Children, Journal Year: 2024, Volume and Issue: 11(7), P. 871 - 871

Published: July 18, 2024

Antibiotic, analgesic sedative, and antiseizure medications are among the most commonly used in preterm/sick neonates, who at high risk of nosocomial infections, central nervous system complications, exposed to numerous painful/stressful procedures. These severe potentially life-threatening complications may have serious short- long-term consequences should be prevented and/or promptly treated. The reported variability neonates indicates lack adequate neonatal studies regarding their effectiveness safety. Important obstacles contributing inadequate infants include difficulties obtaining parental consent, physicians’ unwillingness recruit preterm infants, off-label use many other scientific ethical concerns. This review is an update on antimicrobials (antifungals), analgesics (sedatives), focusing current evidence or knowledge gaps pharmacokinetics, indications, safety, dosage, evidence-based guidelines for optimal neonates. We also address effects early antibiotic intestinal microbiome its association with immune-related diseases, obesity, neurodevelopment (ND). Recommendations empirical treatment emergence pathogen resistance antifungals presented. Finally, future perspectives prevention, modification, reversal discussed.

Language: Английский

Citations

1
A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases DOI Creative Commons
Can Gao,

Jiaxiao Wei,

Changxu Lu

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 21, 2024

Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, inflammation, have been identified with boosting morbidity mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies shown that variations in gut microbiota its own metabolites can influence occurrence CMDs. Intriguingly, composition function are susceptible exercise patterns, thus affecting inflammatory, immune, responses within host. this review, we introduce key mechanisms intestinal microecology involved onset development CMDs, discuss relationship between microecology, then analyze role beneficial effects on aiming at elucidating gut-heart axis mediated protective effect building avenues for application management

Language: Английский

Citations

1
Special Issue: “Gut Microbiota and Nutrition in Human Health” DOI Open Access
Sunmin Park

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11589 - 11589

Published: Oct. 29, 2024

The microbiome is a singular term for vast array of life forms that live symbiotically within the bodies human and animal hosts, forming commensal, parasitic, or mutualistic relationships [...]

Language: Английский

Citations

1