Impact of dementia and mild cognitive impairment on bone health in older people DOI Creative Commons
Elizabeth M. Curtis, Màrio Miguel Rosa, Claire T. McEvoy

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 37(1)

Published: Dec. 27, 2024

Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly global population, increasing in prevalence. These conditions closely associated, shared risk factors, underlying biological mechanisms potential direct causal pathways. In this review, epidemiological mechanistic links between mild skeletal health explored. Discussion will focus on how changes brain bone signalling can underly associations these conditions, consider molecular cellular drivers context inflammation gut microbiome. There is a complex interplay nutritional changes, which may precede or follow onset impairment (MCI) dementia, health. Polypharmacy patients MCI there difficult prescribing decisions to be made due elevated falls associated many drugs used for problems, consequently increase fracture risk. Some medications prescribed directly impact addition, have difficulty remembering medication without assistance, meaning that but not taken. Cognitive improved delayed by physical activity exercise, evidence additional benefits fractures. Research gaps priorities aim reducing burden fractures people also discussed.

Language: Английский

Mediterranean Diet and Quality of Life in Adults: A Systematic Review DOI Open Access
Justyna Godos, Monica Guglielmetti, Cinzia Ferraris

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 577 - 577

Published: Feb. 5, 2025

Background/Objectives: With the increasing life expectancy and, as a result, aging of global population, there has been rise in prevalence chronic conditions, which can significantly impact individuals’ health-related quality life, multidimensional concept that comprises an individual’s physical, mental, and social wellbeing. While balanced, nutrient-dense diet, such Mediterranean is widely recognized for its role disease prevention, particularly reducing risk cardiovascular diseases certain cancers, potential benefits extend beyond these well-known effects, showing promise improving physical mental wellbeing, promoting life. Methods: A systematic search scientific literature electronic databases (Pubmed/Medline) was performed to identify potentially eligible studies reporting on relation between adherence diet published up December 2024. Results: total 28 were included this review, comprising 13 conducted among general population 15 involving various types patients. Overall, most showed significant association HRQoL, with results retrieved domains suggesting seems play relevant both people affected by conditions inflammatory basis. Conclusions: Adherence provides preventing managing commonly associated populations. Furthermore, it enhances overall health individuals, ultimately supporting more effective less invasive treatment approaches diseases.

Language: Английский

Citations

2
The impact of the Mediterranean diet on immune function in older adults DOI Creative Commons
Fiona Ecarnot, Stefania Maggi

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: May 23, 2024

Abstract Diet is one of the lifestyle factors that most amenable to intervention, and has a substantial effect on potential for successful aging mitigation risk disease. Good nutrition pillar healthy aging, large body evidence attests benefits Mediterranean diet quality process. The comprises wide range nutrients which, both individually collectively, exert positive effects immunity, in part mediated by gut microbiota. In this article, we review how its beneficial are We certain key components dietary pattern, including vitamins, zinc, selenium, polyphenols. Overall, existing convincingly demonstrates Mediterreanean affects immune health maintaining weight reducing metabolic cardiovascular diseases; inflammation promoting microbiota profile.

Language: Английский

Citations

8
Dietary fibre optimisation in support of global health DOI Creative Commons
Anouschka S. Ramsteijn, Petra Louis

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(8)

Published: Aug. 1, 2024

Abstract The human gut microbiota influences its host via multiple molecular pathways, including immune system interactions, the provision of nutrients and regulation physiology. Dietary fibre plays a crucial role in maintaining healthy as primary nutrient energy source. Industrialisation has led to massive decrease habitual intake recent times, intakes across world are below national recommendations. This goes hand with other factors industrialised societies that may negatively affect microbiota, such medication increased hygiene. Non‐communicable diseases on rise urbanised optimisation dietary can help improve global health prevent disease. Early life interventions shape developing counteract malnutrition, both context nations an overabundance cheap, highly processed foods, well Low‐ Middle‐Income Countries (LMICs). Adequate should, however, be maintained course promote health. Here we will discuss current state research consider different intervention approaches.

Language: Английский

Citations

4
Roadmap for alleviating the manifestations of ageing in the cardiovascular system DOI
Luca Liberale, Simon Tual‐Chalot, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
The Impact of Diet on the Colonization of Beneficial Microbes from an Ecological Perspective DOI
Zelin Chen,

Chuntao Xiao,

Jintun Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

With growing recognition of the pivotal role gut microbiota in human health, probiotics have gained widespread attention for their potential to restore microbial homeostasis. However, a critical challenge persists: limited colonization efficiency among most probiotic strains compromises therapeutic efficacy. This overview synthesizes ecological principles with cutting-edge microbiome research elucidate dynamic interplay between dietary components and within intestinal niche. systematically analyzes: (1) stage-specific mechanisms spanning introduction, establishment, proliferation; (2) nutrient-driven modulation composition function; (3) dual common patterns as both facilitators disruptors persistence. Notably, this identifies key strategies, including precision delivery prebiotic fibers polyphenol-microbiota crosstalk, that enhance niche adaptation through pH optimization, adhesion potentiation, competitive exclusion pathogens. Furthermore, critically evaluates current limitations research, particularly strain-specific variability methodological constraints simulating host-microbe-diet tripartite interactions. To bridge these gaps, proposes an interdisciplinary framework integrating omics-driven strain selection, engineered systems, personalized nutrition models. Collectively, work advances mechanistic understanding diet-microbiota interactions while providing actionable insights developing targeted therapies evidence-based interventions optimize ecosystem resilience.

Language: Английский

Citations

0
Mediterranean diet, diet quality, and adequacy to Italian dietary recommendations in southern Italian adults DOI
Justyna Godos, G. Zappalà, Antonio Mistretta

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Aug. 30, 2024

OBJECTIVE: This study aimed to explore the relation between adherence Mediterranean diet, adequacy Italian dietary recommendations, and several domains of diet quality in a sample adults. METHODS: The habits total 1936 participants were investigated. Adherence assessed through Medi-Lite Diet Quality Index-International (DQI-I). RESULTS: global DQI-I score positively correlated with score. Negative coefficients found for protein intake calcium category, fat moderation fatty acid ratio overall balance category. More than half adherent national recommendations potatoes, cereals, red meat, other fats consumption. In contrast, on legumes, fruit, vegetables, processed meat met by about while those dairy products (milk yogurt) cheese, eggs, white rather underrepresented. Higher scores well predicted fruit legumes. CONCLUSIONS: Individuals reporting higher show better probability meeting recommendations.

Language: Английский

Citations

3
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study DOI Open Access

Yuji Naito,

Takeshi Yasuda, Hiroaki Kitae

et al.

Journal of Clinical Biochemistry and Nutrition, Journal Year: 2024, Volume and Issue: 75(2), P. 161 - 173

Published: Jan. 1, 2024

In strategies to extend a healthy lifespan, early detection and prevention of frailty are critical. The purpose this study was analyze the current state clinical risk factors among community-dwelling older conduct cross-sectional analysis individuals, correlation between nutrient intake, dietary diversity, patterns, elucidate frailty-related gut microbiota. included 786 participants aged ≥65 years from Kyotango Multipurpose Cohort Study who had available data on their Frailty quantitatively assessed by selecting 32 items previously reported index, with those scoring ≥0.21 classified as (

Language: Английский

Citations

1
Association between dried fruit intake and kidney function: research from univariate and multivariate Mendelian randomized studies DOI Creative Commons

Yuhang Gao,

Xinghai Yue,

Wei Zhao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

Objectives Observational studies have identified an association between dried fruit intake and kidney function. However, these limitations such as vulnerability to confounders reverse causality bias. Therefore, this study aimed explore the potential causal relationship Methods A two-sample Mendelian randomization (MR) was conducted using a large-scale genome-wide dataset investigate function markers (blood urea nitrogen (BUN), creatinine (CR), uric acid (UA), cystatin C (CyC), hematuria, microalbuminuria). The main analytical method inverse variance weighting. In addition, we applied MR Egger weighted median assess robustness of results. Finally, Multivariate (MVMR) used estimate direct effect on markers. Results univariate analysis showed that increased associated with lower markers, including BUN ( β : −0.171, 95% confidence interval (CI): −0.239 −0.102, p = 1.063 × 10 −6 ), CR −0.205, CI: −0.311 −0.099, 1.455 −4 UA −0.317, −0.384 −0.249, 4.439 −20 CysC −0.323, 1.074 −11 ); however, it unrelated hematuria microalbuminuria. Causality persisted after performing MVMR analysis; addition alcohol consumption smoking exposure factors, for −0.296, −0.523 −0.068, 1.094 −2 ) −0.238, −0.465 −0.011, 4.024× weakened, while −0.038, −0.215 0.138, 6.698 −1 −0.431 0.046, 1.347 disappeared. Conclusion Increased (BUN, CR, UA, CysC) in absence consumption; disappeared presence consumption. These results provide promising avenue delaying course chronic disease.

Language: Английский

Citations

0
Divine life force: the fragile power of blood DOI Creative Commons
Aila Akosua Kattner

Biomedical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 100804 - 100804

Published: Oct. 1, 2024

Language: Английский

Citations

0
Using nutrition to help recovery from infections DOI
Inês B. Moura, Anthony M. Buckley

Current Opinion in Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Antibiotics are a cornerstone of modern medicine, but antibiotic consumption can have depleting effects on the gut microbiota, potentially leading to gastrointestinal symptoms and other diseases, namely Clostridioides difficile infection. Because nutrition is major driver microbiota diversity function, here we explore current evidence potential diets in alleviate deleterious antibiotics consumed during infections.

Language: Английский

Citations

0