Renal function protection and the mechanism of ginsenosides: Current progress and future perspectives DOI Creative Commons

Meiling Fan,

Xintian Lan,

Qunling Wang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Nephropathy is a general term for kidney diseases, which refers to changes in the structure and function of caused by various factors, resulting pathological damage kidney, abnormal blood or urine components, other diseases. The main manifestations disease include hematuria, albuminuria, edema, hypertension, anemia, lower back pain, oliguria, symptoms. Early detection, diagnosis, active treatment are required prevent chronic renal failure. concept nephropathy encompasses wide range conditions, including acute injury, disease, nephritis, fibrosis, diabetic nephropathy. Some these kidney-related diseases interrelated may lead serious complications without effective control. In cases, it can also develop into dysfunction eventually end-stage disease. As result, seriously affects quality life patients places great economic burden on society families. Ginsenoside one components ginseng, with anti-inflammatory, anti-tumor, antioxidant, pharmacological activities. A variety monomers ginsenosides play protective roles multiple organs. According difference core structure, be divided protopanaxadiol-type (including Rb1, Rb3, Rg3, Rh2, Rd CK, etc.), protopanaxatriol (protopanaxatriol)- type Rg1, Rg2 Rh1, types Rg5, Rh4, Rh3, Rk1, Rk3, etc.). All showed significant protection, reduce models. This review summarizes reports protection mechanisms action injury

Language: Английский

Pharmacological functions of salidroside in renal diseases: facts and perspectives DOI Creative Commons
Qiong Liu, Jianzhu Chen,

Anqi Zeng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.

Language: Английский

Citations

14
Targeting novel regulated cell death：Ferroptosis, pyroptosis, and autophagy in sepsis-associated encephalopathy DOI Open Access

Jingjing Sun,

Joshua S. Fleishman, Xueyan Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116453 - 116453

Published: March 20, 2024

Sepsis-associated encephalopathy (SAE), a common neurological complication of sepsis, is heterogenous complex clinical syndrome caused by the dysfunctional response host to infection. This leads excess mortality and morbidity worldwide. Despite relevance with high incidence, there lack understanding for its both acute/chronic pathogenesis therapeutic management. A better molecular mechanisms behind SAE may provide tools enhance efficacy. Mounting evidence indicates that some types non-apoptotic regulated cell death (RCD), such as ferroptosis, pyroptosis, autophagy, contribute SAE. Targeting these RCD meaningful targets future treatments against review summarizes core mechanism which We focus on emerging compounds can inhibit delineate their beneficial pharmacological effects Within this we suggest inhibition serve potential strategy

Language: Английский

Citations

14
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species DOI Creative Commons

Zhongqiang Zhu,

Jun Li, Zhiyong Song

et al.

Clinical Science, Journal Year: 2024, Volume and Issue: 138(5), P. 235 - 249

Published: Feb. 15, 2024

Abstract Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). Recently, ferroptosis was reported to be crucial for AKI pathogenesis. Our previous studies indicated antioxidant tetramethylpyrazine (TMP) prevent CIN in vivo. However, whether involved TMP nephroprotective mechanism against unclear. In the present study, we investigated role renal tubular epithelial cell reno-protective effect and molecular mechanisms by which regulates ferroptosis. Classical contrast-medium, Iohexol, used construct models rats HK-2 cells. Results showed that accompanied both vivo vitro, including typical features ferroptosis, Fe2+ accumulation, lipid peroxidation decreased glutathione peroxidase 4 (GPX4). Ferroptosis inhibition classic inhibitors Fer-1 DFO promoted viability reduced intracellular ROS production. Additionally, significantly inhibited dysfunction, biomarkers, prevented production, accumulation increased GPX4 expression. Expressions various proteins associated with iron ion metabolism, transferrin receptor (TFRC), divalent metal transporter 1, iron-responsive element binding protein 2, ferritin heavy chain ferroportin heat shock factor were examined using mechanistic analyses. Among these, TFRC changes most significant after pretreatment. siRNA knockdown plasmid overexpression essential alleviate reduce LDH release, ROS. findings provide insights about potential treating

Language: Английский

Citations

9
Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis DOI Creative Commons

Xingyue Chen,

Lijia Zhi, Jun Chen

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Sepsis-associated acute kidney injury (SA-AKI) commonly occurs in critically ill patients and is closely associated with adverse outcomes. A comprehensive analysis of the current research landscape SA-AKI can help uncover trends key issues this field. This study aims to provide a scientific basis for directions critical through bibliometric analysis. We searched all articles on indexed SCI-Expanded WoSCC up May 7, 2024, conducted visual analyses using software CiteSpace VOSviewer. Over past 20 years, there has been steady increase literature related renal repair following AKI. China United States contribute over 60% publications, driving The University Pittsburgh most active academic institution, producing highest number publications. J. A. Kellum both prolific cited author area. "Shock" "American Journal Physiology-Renal Physiology" are popular journals, publishing articles. Recent high-frequency keywords field include "septic AKI," "mitochondrial dysfunction," "inflammasome," "ferroptosis," "macrophage." terms "macrophage" represent hotspots potential targets first summarize advancements recent years. These findings identify frontiers hot topics, providing valuable insights scholars studying SA-AKI.

Language: Английский

Citations

1
Exploring Liraglutide’s mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway DOI Creative Commons
Qi Chen, Ji‐Xian Song, Zhi Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 12, 2025

Studies have confirmed that elevated glucose levels could lead to renal fibrosis through the process of ferroptosis. Liraglutide, a human glucagon-like peptide-1 (GLP-1) analogue, is potential treatment option for diabetes. This study aimed examine liraglutide (LIRA) in inhibiting ferroptosis and reducing high glucose-induced fibrotic injury mice, whether Fsp1-CoQ10-NAD(P)H signal pathway mechanism this effect. In our study, we used db/db mice simulate Type 2 diabetes mellitus (T2DM). The were intraperitoneally injected with LIRA (200 µg/kg/d) daily 6 weeks. Renal function, pathologic changes, lipid peroxidation levels, iron assessed. First, ameliorated dysfunction mice. Second, inhibited by up-regulating T-SOD, GSH-Px, GSH activities as well down-regulating 8-OHDG, MDA, LPO, 4-HNE, 12-Lox, NOX4 addition, attenuated deposition decreasing expression TfR1 increasing FPN1. Meanwhile, reduced cell viability decline intracellular peroxidation. Furthermore, adjusting vivo vitro. These findings suggested kidney pathway.

Language: Английский

Citations

1
CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2 cells by promoting oxidative stress DOI Open Access
Zhihui Zhou, Hongwei Zhang

Allergologia et Immunopathologia, Journal Year: 2023, Volume and Issue: 51(2), P. 99 - 110

Published: March 1, 2023

Background: Sepsis-induced acute kidney injury (AKI) is a singularly grievous and life-threatening syndrome. Its pathogenesis closely related to inflammatory response, apoptosis, oxidative stress, ferroptosis. Cation transport regulator-like protein 1 (CHAC1), as proapoptic factor, may be involved in This study aimed explore the role of CHAC1 lipopolysaccharide (LPS)-induced human renal proximal tubular epithelial (HK-2) cells. Methods: HK-2 cells were challenged with LPS construct model sepsis-induced AKI vitro. The LPS-induced was explored using Western blot assay, cell counting kit-8 (CCK-8), flow cytometry, colorimetric assays. Additionally, N-acetyl cysteine (NAC) incubated define deeply relation between stress apoptosis or Results: expression enhanced tissues mice sepsis--induced multiple organ dysfunction syndrome (MODS), through Gene Expression Omnibus database (GSE60088 microarray dataset), viability significantly reduced by treatment, which at least partly restored transfection siCHAC1#1 siCHAC1#2 but not siNC. In addition, down-regulation counteracted reactive oxygen species level malonaldehyde concentrations while glutathione concentrations. Meanwhile, interference neutralized rate, relative cleaved poly(ADP-ribose) polymerase (PARP)/PARP, caspase-3/caspase-3. silencing recovered peroxidase 4 (GPx4) whereas antagonized ACSL4 that iron. Moreover, application NAC inverted effect on ferroptosis Conclusion: exacerbated enhancing

Language: Английский

Citations

19
NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease DOI Creative Commons

Yasenjiang Maimaiti,

Ting Su, Zhanying Zhang

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 2, 2024

Abstract This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD RNA data, identified marker genes, explored biological processes astrocytes. integrated AD-related chip with ferroptosis-related highlighting NOX4. validated NOX4’s role ferroptosis vitro vivo. Astrocyte genes were enriched AD, emphasizing their role. NOX4 emerged as a crucial player astrocytic AD. Silencing mitigated ferroptosis, improved cognition, reduced Aβ p-Tau levels, alleviated mitochondrial abnormalities. promotes underscoring its significance progression.

Language: Английский

Citations

8
Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1/Nrf2 cascade and ameliorating mitochondrial damage DOI
Guangwen Shu,

Chuo Wang,

Anning Song

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118648 - 118648

Published: July 31, 2024

Language: Английский

Citations

8
From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis DOI Creative Commons
Zhi Liu, Ting Yuan, Miao Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 26, 2024

Sepsis is a syndrome precipitated by immune dysregulation in response to infection, and represents pivotal factor global mortality attributed diseases. The recent consensus delineates sepsis as perilous state of organ dysfunction arising from the host’s maladaptive reaction infection. It masks complexity breadth mechanisms involved sepsis, which characterized simultaneous hyperinflammation immunosuppression. highly correlated with response, mainly mediated various cells their interactions. This can lead plethora complications, encompassing systemic inflammatory metabolic disturbances, infectious shock, MODS, DIC. Furthermore, more research studies have been conducted on past few years. pathological characteristics improved or treated targeting signaling pathways like NF-B, JAK–STAT, PI3K-Akt, p38-MAPK. Combined drug therapy better than single for sepsis. article will review latest progress pathogenesis treatment

Language: Английский

Citations

8
Novel Insight into Ferroptosis in Kidney Diseases DOI
Yang Liu, Yong Liu,

Sijie Zhou

et al.

American Journal of Nephrology, Journal Year: 2023, Volume and Issue: 54(5-6), P. 184 - 199

Published: Jan. 1, 2023

Background: Various kidney diseases such as acute injury, chronic disease, polycystic renal cancer, and stones, are an important part of the global burden, bringing a huge economic burden to people around world. Ferroptosis is type nonapoptotic iron-dependent cell death caused by excess lipid peroxides accompanied abnormal iron metabolism oxidative stress. Over past few decades, several studies have shown that ferroptosis associated with many types diseases. Studying mechanism related agonists inhibitors may provide new ideas directions for treatment various Summary: In this review, we discuss differences between other apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features kidney, ferroptosis-induced injury. We also overview molecular mechanisms involved in events lead ferroptosis. Furthermore, summarize possible clinical applications among Key Message: The current research suggests future therapeutic efforts treat ailments would benefit from focus on

Language: Английский

Citations

16