Natural course of post-COVID symptoms in adults and children

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 16, 2024

Abstract More than 200 million COVID-19 survivors have lasting symptoms after recovering, but the duration and related risk factors remain uncertain. This study focused on all 6551 patients diagnosed with at a medical institution in Hiroshima from March 2020 to July 2022. In November 2022, questionnaire survey was conducted regarding post-COVID their duration. The prevalence of were illustrated using Kaplan–Meier method. Risk for over 3 months interfering daily life assessed via multivariate logistic regression. A total 2421 responded: 1391 adults, 1030 children, median age 34 years (IQR 9–55), 51·2% male, 36·7% hospitalized, time infection 295 days 201–538). Upon initial recovery, 78·4% adults 34·6% children. Three later, rates 47·6% 10·8%. After one year, they 31·0% 6·8%. Regarding interfere life, 304 people (12.6%) experienced three months, independent including age, being female, diabetes mellitus, during Delta period, current smoking. There no significant association between vaccination history symptoms.

Language: Английский

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Risk of new-onset dementia following COVID-19 infection: a systematic review and meta-analysis

Age and Ageing, Journal Year: 2025, Volume and Issue: 54(3)

Published: March 1, 2025

Emerging evidence suggests coronavirus disease 2019 (COVID-19) infection may increase the risk of developing dementia, although studies have reported conflicting findings. This meta-analysis aimed to synthesise literature on association between COVID-19 and new-onset dementia. PubMed, Embase Web Science were searched for cohort or case-control that investigated dementia development among adult survivors compared individuals without from inception 9 November 2023. Studies exclusively involved populations younger than 18 years, with known lacked adequate data about excluded. Two authors independently conducted screening eligible studies, extraction bias assessment. The primary outcome was following infection. Data pooled using random-effects models, hazard ratios (HRs) 95% confidence intervals (CIs) calculated. A total 15 retrospective encompassing 26 408 378 participants included. Pooled analysis indicated associated an increased (HR = 1.49, CI: 1.33-1.68). remained elevated when non-COVID cohorts 1.65, 1.39-1.95), respiratory tract 1.29, 1.12-1.49), but not influenza sepsis cohorts. Increased observed in both males females, as well older 65 years 1.68, 1.48-1.90), remaining up 24 months. demonstrates a significant which underscores need cognitive monitoring early intervention address potential long-term neurological impacts.

Language: Английский

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Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults

Annals of Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Objective To investigate neurologic manifestations of post‐acute sequelae SARS‐CoV‐2 infection (Neuro‐PASC) in post‐hospitalization Neuro‐PASC (PNP) and non‐hospitalized (NNP) patients across the adult lifespan. Methods Cross‐sectional study first consecutive 200 PNP 1,100 NNP evaluated at a Neuro‐coronavirus disease 2019 (COVID‐19) clinic between May 2020 March 2023. Patients were divided into younger (18–44 years), middle‐age (45–64 older (65+ years) age groups. Results Younger individuals accounted for 142 (71%) 995 1100 (90.5%) patients. Significant age‐related differences frequencies comorbidities abnormal findings demonstrated higher prevalence Conversely, 10 months from COVID‐19 onset, we found significant symptoms indicating lower prevalence, therefore, symptom burden, individuals. Moreover, there subjective impression fatigue (median [interquartile range (IQR)] patient‐reported outcomes measurement information system [PROMIS] score: 64 [57–69], 63 [57–68], 60.5 [50.8–68.3]; p = 0.04) sleep disturbance [IQR] PROMIS 57 [51–63], 56 [53–63], 54 [46.8–58]; 0.002) group, commensurate with impairment quality life (QoL) among Finally, objective executive function National Institutes Health [NIH] toolbox 48 [35–63], 49 [38–63], 54.5 [45–66.3]; 0.01), working memory NIH 47 [40–53], 50 [44–57], [43–58]; 0.0002) patients, worst performance coming group. Interpretation are disproportionally affected by regardless acute severity. Although people more frequently have comorbidities, suffer burden cognitive dysfunction contributing to decreased QoL. principally affects adults their prime, profound public health socioeconomic impacts warranting dedicated resources prevention, diagnosis interventions. ANN NEUROL 2024

Language: Английский

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Trajectory of post-COVID brain fog, memory loss, and concentration loss in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 9, 2023

This study aimed to apply Sankey plots and exponential bar for visualizing the trajectory of post-COVID brain fog, memory loss, concentration loss in a cohort previously hospitalized COVID-19 survivors.A sample 1,266 patients due during first wave pandemic were assessed at 8.4 (T1), 13.2 (T2), 18.3 (T3) months after hospital discharge. They asked about presence following self-reported cognitive symptoms: fog (defined as self-perception sluggish or fuzzy thinking), unusual forgetfulness), not being able maintain attention). We symptoms that individuals had experienced previously, they attributed them acute infection. Clinical hospitalization data collected from medical records.The revealed prevalence was 8.37% (n = 106) T1, 4.7% 60) T2, 5.1% 65) T3, whereas 14.9% 189) 11.4% 145) 12.12% 154) T3. Finally, decreased 6.86% 87) 4.78% 2.63% 33) The recovery curves show decreasing trend, indicating these recovered years regression models did reveal any record associated with long term.The use shows fluctuating evolution In addition, decrease No risk factors identified this cohort.

Language: Английский

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Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Background The relationship between COVID-19 infection and a possible increased likelihood of older adults developing new-onset dementia (NOD) remains elusive. Methods A thorough search was performed across several databases including MEDLINE/PubMed, PsycINFO, Scopus, medRxiv, PQDT Global for studies published in English from January 2020 to December 2023. Only original investigations exploring the link NOD were selected inclusion. We assessed risk NOD, using Risk Ratio (RR) measurement. Control groups categorized as: (i) non-COVID cohort with other respiratory infections [control group (C1)]; (ii) otherwise unspecified health status (C2)]. Follow-up periods divided into intervals 3, 6, 12, 24 months post-COVID. Results 11 (involving 939,824 post-COVID-19 survivors 6,765,117 controls) included review. Across median observation period 12 post-COVID, overall incidence about 1.82% COVID-infected group, compared 0.35% non-COVID-infected group. pooled meta-analysis showed significantly among adult non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). Similar risks observed subgroup analyses restricted an observational 1.56, 1.21–2.01), as well five that employed propensity score matching sufficiently effectively control multiple confounding covariates 1.46, 1.10–1.94). C1 shared comparably (overall RR 1.13, 0.92–1.38). Discussion Under normal circumstances, we believe is likely be factor over time. While due appears similar associated infections, it warrants necessitates investigation longer observations.

Language: Английский

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Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α+β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA / IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r=0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

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Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(5), P. 16 - 16

Published: May 8, 2024

Research on Alzheimer's disease (AD) and precursor states demonstrates a thinner retinal nerve fiber layer (NFL) compared to age-similar controls. Because AD age-related macular degeneration (AMD) both impact older adults share risk factors, we asked if thicknesses, including NFL, are associated with cognition in AMD.

Language: Английский

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The risk of cognitive decline and dementia in older adults diagnosed with COVID-19: A systematic review and meta-analysis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102448 - 102448

Published: Aug. 8, 2024

Language: Английский

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Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4

Published: March 24, 2025

The SAR-CoV-2 virus has evolved to co-exist with human hosts, albeit at a substantial energetic cost resulting in post-infection neurological manifestations [Neuro-post-acute sequelae of SARS-CoV-2 infection (PASC)] that significantly impact public health and economic productivity on global scale. One the main molecular mechanisms responsible for development Neuro-PASC, individuals all ages, is formation inadequate proteolysis/clearance phase-separated amyloid crystalline aggregates—a hallmark feature aging-related neurodegenerative disorders. Amyloidogenesis during viral persistence natural, inevitable, protective defense response exacerbated by SARS-CoV-2. Acting as chemical catalyst, accelerates hydrophobic collapse heterogeneous nucleation amorphous amyloids into stable β-sheet aggregates. clearance aggregates most effective slow wave sleep, when high levels adenosine triphosphate (ATP)—a biphasic modulator biomolecular condensates—and melatonin are available solubilize removal. dysregulation mitochondrial dynamics SARS-CoV-2, particular fusion fission homeostasis, impairs proper distinct subpopulations can remedy challenges created diversion substrates away from oxidative phosphorylation towards glycolysis support replication maintenance. subsequent reduction ATP inhibition synthesis sleep results incomplete brain aggregates, leading commonly associated age-related Exogenous not only prevents dysfunction but also elevates production, effectively augmenting solubilizing effect moiety ensure timely, optimal disaggregation pathogenic prevention attenuation Neuro-PASC.

Language: Английский

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Updates on the neurological manifestations of SARS-CoV-2 infection

Current Opinion in Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Purpose of review Since its emergence in 2020, the COVID-19 pandemic has created a global surge survivors experiencing neurologic effects from SARS-CoV-2 infection. This aims to provide an updated synthesis acute and chronic neurological manifestations COVID-19, outline current therapeutic strategies for these conditions. Recent findings Epidemiological studies have shown that patients with symptoms during infection tend poorer hospital functional outcomes. While risk adverse including cognitive dysfunction, headache, autonomic fatigue are thought be greatest following original strain alpha variant, they remain prevalent after subsequent less virulent strains as well. Some recent work also found link between structural brain changes. However, ongoing trials show promising results pharmacologic nonpharmacologic treatments targeting postacute sequelae COVID-19. Summary Lingering still pose considerable individual, healthcare system, socioeconomic repercussions. Both preventive multimodal treatment approaches necessary address Further research is required assess lasting impacts on nervous particularly potential contribution development neurodegenerative diseases.

Language: Английский

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