Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 19, 2024

Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Individuals with PCA have relatively dementia, posing certain needs for early detection. Hence, this study aimed to investigate the association of alterations in outer retinal choroidal structure microvasculature neuroimaging clinical features possible effects apolipoprotein E(APOE) ε4 allele on participants PCA, detect potential ocular biomarkers screening.

Language: Английский

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Band Visibility in High-Resolution Optical Coherence Tomography Assessed With a Custom Review Tool and Updated, Histology-Derived Nomenclature

Translational Vision Science & Technology, Journal Year: 2024, Volume and Issue: 13(12), P. 19 - 19

Published: Dec. 13, 2024

Purpose: For structure-function research at the transition of aging to age-related macular degeneration, we refined current consensus optical coherence tomography (OCT) nomenclature and evaluated a novel review software for investigational high-resolution OCT imaging (HR-OCT; <3 µm axial resolution). Method: Volume electron microscopy, immunolocalizations, histology, devices informed custom ImageJ-based tool assess retinal band visibility. We examined effects on visibility automated real-time averaging (ART) 9 100 (11 eyes 10 healthy young adults), (10 vs 22 aged), degeneration (AMD; aged, 17 early (e)AMD, 15 intermediate (i)AMD). Intrareader reliability was assessed. Results: Bands not included in are now visible using HR-OCT: inner plexiform layer (IPL) 1-5, outer (OPL) 1-2, segment interdigitation zone 1-2 (OSIZ, including hyporeflective segments), pigment epithelium (RPE) 1-5. Cohen's kappa 0.54–0.88 0.67–0.83 bands subset eyes. IPL-3-5 OPL-2 benefitted from increased ART. OSIZ-2 RPE-1,2,3,5 worse aged than OSIZ-1-2, RPE-1, RPE-5 decreased eAMD iAMD compared Conclusions: reliably identified 28 HR-OCT. Image improved Aging AMD development impacted Translational Significance: Detailed knowledge anatomic structures will enhance precision research, AI training analyses.

Language: Английский

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Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(8), P. 34 - 34

Published: July 19, 2024

Purpose: A single-nucleotide polymorphism in HTRA1 has been linked to age-related macular degeneration (AMD). Here we investigated the potential links between retinal changes, elastin turnover, autoantibody production, and complement C3 deposition a mouse model with RPE-specific human overexpression. Methods: transgenic mice age-matched CD1 wild-type were analyzed at 6 weeks 4, 6, 12 14 months of age using vivo imaging by optical coherence tomography (OCT) fundus photography, as well molecular readouts, focusing on elastin-derived peptide quantification, antielastin autoantibody, total Ig antibody measurements immunohistochemistry examine elastin, IgG, protein levels sections. Results: OCT indicated thinning inner nuclear layer an early phenotype mice, followed age/genotype-related photoreceptor layer, RPE, retina. exhibited reduced RPE/choroid increased breakdown products retina serum. corresponding age-dependent increase serum IgG IgM autoantibodies was observed. In RPE/choroid, these changes associated deposition. Conclusions: Our results confirm that overexpression induces certain AMD-like phenotypes mice. This includes altered immune response, addition outer thinning. The identification peptides autoantibodies, together provides rationale for overactive system AMD irrespective underlying genetic risk.

Language: Английский

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Outer retinal thinning is associated with brain atrophy in early age-related macular degeneration

American Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 269, P. 457 - 465

Published: Oct. 5, 2024

Language: Английский

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