Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(10)
Published: Oct. 1, 2023
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Language: Английский
Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 21 - 21
Published: Jan. 4, 2025
The COVID-19 pandemic has highlighted the urgent need for rapid, sensitive, and reliable diagnostic tools detecting SARS-CoV-2. In this study, we developed optimized a surface plasmon resonance (SPR) biosensor incorporating advanced materials to enhance its sensitivity specificity. Key parameters, including thickness of silver layer, silicon nitride dielectric molybdenum disulfide (MoS2) layers, ssDNA recognition were systematically achieve best balance between sensitivity, resolution, attenuation. configuration, consisting 45 nm 13 2 MoS2 5 demonstrated superior performance SARS-CoV-2 in PBS solution. exhibited high at low viral concentrations, achieving 375.01°/RIU, detection accuracy 0.002, quality factor 38.34 1.0 mM concentration. Performance metrics validated sensor’s capability detection, particularly early-stage diagnostics where timely intervention is critical. Moreover, biosensor’s linear response refractive index changes confirmed potential quantitative concentration analysis. This study underlines significance integrating materials, such as nitride, SPR performance. findings establish proposed robust precise tool with applications clinical epidemiological monitoring.
Language: Английский
Citations
2
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.
Language: Английский
Citations
1
Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 370 - 370
Published: Feb. 27, 2024
The COVID-19 pandemic has profoundly impacted global health, leading to extensive research focused on developing strategies enhance outbreak response and mitigate the disease’s severity. In aftermath of pandemic, attention shifted towards understanding addressing long-term health implications, particularly in individuals experiencing persistent symptoms, known as long COVID. Research into potential interventions alleviate COVID symptoms intensified, with a focus support immune function inflammation. One area interest is gut microbiota, which plays crucial role regulating responses maintaining overall health. Prebiotics probiotics, for their ability modulate have emerged therapeutic agents bolstering reducing This review delves intricate relationship between COVID, function, specific prebiotics probiotics. We examine emphasizing importance inflammation regulation persistence symptoms. probiotics modulating responses, including mechanisms combating viral infections such COVID-19, discussed detail. Clinical evidence supporting use managing summarized, highlighting adjunctive therapy various aspects SARS-CoV-2 infection its aftermath.
Language: Английский
Citations
5
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(9)
Published: Sept. 1, 2023
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Language: Английский
Citations
13
Published: Jan. 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
Abstract Leishmania tropica is causing cutaneous leishmaniasis (CL) from North Africa to India and in Ethiopia reported be transmitted humans through sand fly bites. While this species characterized by a high genetic diversity all over the area of endemicity, there very little information on at micro-epidemiological scale. Here, we zoomed an epidemic Moroccan focus CL - restricted space time studied transmission patterns comparative genomics parasites human patients. We used culture-independent method genome sequencing based capture (SureSelect-sequencing, SuSL-seq), applied directly dermal scrapings. first compared paired samples: i.e. host tissues analyzed SuSL-seq derived isolates shortly maintained culture whole (WGS). Despite low passage number isolates, significant differences were observed between karyotypes 4/7 samples, highlighting clinical epidemiological relevance direct sequencing. Secondly, identified 7 groups nearly identical genotypes, characteristic clonal propagation as well with mixed ancestry, signature exchange. Our results reveal micro-focal among humans, underlain sexual reproductive modes. This study demonstrates power for evolutionary genetics
Language: Английский
Citations
0
COVID, Journal Year: 2025, Volume and Issue: 5(5), P. 66 - 66
Published: April 30, 2025
Background: This study aimed to investigate the provision of dental care patients admitted a public tertiary hospital due SARS-CoV-2 infection. Methods: A chart review was conducted using medical records with confirmed diagnosis infection at hospital. Patients hospitalized for least 10 days were included, and data collected on demographic variables, comorbidities, oral health status, hospitalization outcomes. Results: total 295 included (mean age 60.8 ± 17.4 years). Comorbidities common, 29.8% diagnosed diabetes 53.3% hypertension. Only 47.5% received an assessment upon admission, 58% hygiene during hospitalization. Oral evaluations revealed that older adults exhibited significantly higher rates edentulism, more hospitalization, likely undergo evaluation admission. Regarding clinical outcomes, altered mouth opening had lower Glasgow Coma Scale scores (p < 0.001), those mucosa showed reduced oxygen saturation levels = 0.006). Conclusions: These findings highlight importance in critically ill COVID-19 patients, particularly ICU settings. It emphasizes need improved documentation integration professionals into hospital-care teams reduce complications enhance both systemic
Language: Английский
Citations
0
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(9)
Published: Sept. 1, 2023
Abstract The severe acute respiratory syndrome coronavirus 2 EG.5 lineage is the latest variant under monitoring, and it generating significant concern due to its recent upward trend in prevalence. Our aim was gain insights into this emerging offer actual level of threat. Both genetic structural data indicate that novel presently lacks substantial evidence having a high capacity for widespread transmission. Their viral population sizes expanded following very mild curve peaked several months after earliest detected sample. Currently, neither size nor first descendant increasing. variability appear be flattened, as evidenced by relatively modest evolutionary rate (9.05 × 10 −4 subs/site/year). As has been observed with numerous prior variants, attributes might theoretically provide advantages seem stem from drift, enabling virus continually adjust host, albeit without clear association enhanced dangerousness. These findings further underscore necessity ongoing genome‐based ensuring preparedness well‐documented understanding unfolding situation.
Language: Английский
Citations
10
Viruses, Journal Year: 2025, Volume and Issue: 17(1), P. 125 - 125
Published: Jan. 17, 2025
Human outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) are more common in Eastern and Asian human populations, associated with clades A B. In Africa, where clade C is dominant camels, cases minimal. We reviewed 16 studies (n = 6198) published across seven African countries between 2012 2024 to assess MERS-CoV cases. also analyzed data from four cohort conducted camel-keeping communities 2018 involving camel keepers, slaughterhouse workers, hospital patients acute illness (ARI). The analysis showed a pooled prevalence 2.4% (IQR: 0.6, 11.4) publications 1.14% 4 2353). Symptomatic were rarely reported, most individuals reporting contact, only 12% had travel history the East. There was one travel-associated reported death, resulting mortality rate 0.013%. findings suggest low camel-to-human transmission Africa. Ongoing research focuses on genomic comparisons virulent B, alongside surveillance viral evolution. This study highlights need for continuous monitoring but indicates that currently poses minimal public health threat
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177449 - 177449
Published: Nov. 19, 2024
Wastewater-based epidemiology (WBE) is an effective, non-invasive method for monitoring the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by tracking viral prevalence in water. This study aimed to investigate presence SARS-CoV-2 surface water Vietnam over two years. One-step quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays were employed quantify and its variant-specific mutation sites (G339D/E484A) pepper mild mottle virus (PMMoV) from a total 315 samples (105 per type) compare with reported Coronavirus disease 2019 (COVID-19) cases environmental factors. was detected 38 % (40/105), 43 (45/105), 39 (41/105) Sites A, B, C, respectively, concentrations 3.0-5.6 log
Language: Английский
Citations
2