Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Jan. 28, 2021
Brain
disorders
include
neurodegenerative
diseases
(NDs)
with
different
conditions
that
primarily
affect
the
neurons
and
glia
in
brain.
However,
risk
factors
pathophysiological
mechanisms
of
NDs
have
not
been
fully
elucidated.
Homeostasis
intracellular
Ca
2+
concentration
pH
(pH
i
)
is
crucial
for
cell
function.
The
regulatory
processes
these
ionic
may
be
absent
or
excessive
pathological
conditions,
leading
to
a
loss
death
distinct
regions
ND
patients.
Herein,
we
review
potential
involvement
transient
receptor
(TRP)
channels
NDs,
where
disrupted
homeostasis
leads
death.
capability
TRP
restore
excite
through
regulation
depending
on
level
plasma
membrane
ATPase
(PMCA)
activity
discussed
detail.
As
PMCA
simultaneously
affects
as
well
,
thus
play
vital
roles
modulating
various
types
specific
brain
are
expressed.
For
this
reason,
dysfunction
and/or
under
disrupts
neuronal
due
abnormal
levels
brain,
resulting
NDs.
This
addresses
function
controlling
pH,
which
provide
novel
targets
treating
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2019,
Volume and Issue:
11(10), P. a034025 - a034025
Published: March 4, 2019
Maria
K.
Janowska,
Hannah
E.R.
Baughman,
Christopher
N.
Woods
and
Rachel
E.
Klevit
Department
of
Biochemistry,
University
Washington,
Seattle,
Washington
98195
Correspondence:
klevit{at}uw.edu
Reviews in the Neurosciences,
Journal Year:
2020,
Volume and Issue:
31(4), P. 391 - 413
Published: Feb. 4, 2020
Abstract
The
link
between
histopathological
hallmarks
of
Alzheimer’s
disease
(AD),
i.e.
amyloid
plaques,
and
neurofibrillary
tangles,
AD-associated
cognitive
impairment,
has
long
been
established.
However,
the
introduction
interactions
amyloid-beta
(Aβ)
as
well
hyperphosphorylated
tau,
cholinergic
system
to
territory
descriptive
neuropathology
drastically
changed
this
field
by
adding
theory
synaptic
neurotransmission
toxic
pas
de
deux
in
AD.
Accumulating
data
show
that
a
multitarget
approach
involving
all
amyloid,
hypotheses
could
better
explain
evolution
events
happening
Various
species
both
Aβ
tau
be
traced
neurons
basal
forebrain
early
course
disease.
These
molecules
induce
degeneration
system.
Reciprocally,
aberrant
modulation
promotes
changes
precursor
protein
(APP)
metabolism
phosphorylation,
resulting
neurotoxicity,
neuroinflammation,
neuronal
death.
Altogether,
these
may
correlate
with
clinical
findings
impairment
detected
AD
patients.
Failure
several
Aβ-
tau-related
therapies
further
highlights
need
for
special
attention
target
mentioned
pathologic
changes.
Another
noteworthy
fact
here
is
none
popular
such
amyloidopathy
or
tauopathy
seem
responsible
observed
alone.
Thus,
main
culprit
should
sought
higher
stream
somewhere
APP
Wnt
signaling
forebrain.
Future
studies
pathological
events.
Journal of Cell Science,
Journal Year:
2023,
Volume and Issue:
136(10)
Published: May 3, 2023
Transient
changes
in
intracellular
pH
(pHi)
regulate
normal
cell
behaviors,
but
roles
for
spatiotemporal
pHi
dynamics
single-cell
behaviors
remain
unclear.
Here,
we
mapped
during
mammalian
cycle
progression
both
with
and
without
synchronization.
We
found
that
is
dynamic
throughout
the
cycle:
decreases
at
G1/S,
increases
mid-S,
late
S,
G2/M
rapidly
mitosis.
Importantly,
although
highly
dividing
cells,
non-dividing
cells
have
attenuated
dynamics.
Using
two
independent
manipulation
methods,
low
inhibits
completion
of
S
phase
whereas
high
promotes
S/G2
transitions.
Our
data
also
suggest
cues
G1
exit,
decreased
shortening
increased
elongating
G1.
Furthermore,
required
timing,
as
elongates
transition.
This
work
reveals
are
necessary
multiple
transitions
single
human
cells.
Reviews in the Neurosciences,
Journal Year:
2018,
Volume and Issue:
29(5), P. 475 - 489
Published: Jan. 6, 2018
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder
and
characterized
by
a
spectrum
of
clinicopathologic
signs
complex
etiology.
PD
results
from
degeneration
dopaminergic
(DAergic)
neurons
in
substantia
nigra.
Current
therapies
for
are
only
able
to
alleviate
symptoms
without
stopping
progression.
In
addition,
available
therapeutic
strategies
do
not
have
long-lasting
effects.
Furthermore,
these
cause
different
ranges
adverse
side
There
great
interest
neurotrophic
factors
(NTFs)
due
their
ability
promote
survival
neural
cells.
These
divided
into
four
families:
neurotrophins,
neurokines,
glial
cell
line-derived
NTF
family
ligands,
newly
recognized
cerebral
DA
NTF/mesencephalic
astrocyte-derived
family.
The
protective
effects
on
DAergic
make
them
suitable
prevention
progressive
loss
PD.
Based
above
premise,
we
focus
NTFs,
especially
CDNF
MANF,
nigrostriatal
Nucleic Acids Research,
Journal Year:
2018,
Volume and Issue:
unknown
Published: Sept. 19, 2018
Most
frequent
genetic
cause
of
amyotrophic
lateral
sclerosis
(ALS)
and
frontotemporal
dementia
(FTD),
is
a
largely
increased
number
d(G4C2)n•(G2C4)n
repeats
located
in
the
non-coding
region
C9orf72
gene.
Non-canonical
structures,
including
G-quadruplexes,
formed
within
expanded
have
been
proposed
to
drive
repeat
expansion
pathogenesis
ALS
FTD.
Oligonucleotide
d[(G4C2)3G4],
which
represents
shortest
oligonucleotide
model
d(G4C2)
with
ability
form
unimolecular
G-quadruplex,
forms
two
major
G-quadruplex
structures
addition
several
minor
species
coexist
solution
K+
ions.
Herein,
we
used
solution-state
NMR
determine
high-resolution
structure
one
adopted
by
d[(G4C2)3G4].
Structural
characterization
named
AQU
was
facilitated
single
substitution
dG
8Br-dG
at
position
21
revealed
an
antiparallel
fold
composed
four
G-quartets
three
C-C
loops.
The
exhibits
high
thermal
stability
favored
kinetically
under
slightly
acidic
conditions.
An
unusual
structural
element
distinct
from
C-quartet
observed
structure.
Two
C•C
base
pairs
are
stacked
on
nearby
G-quartet
involved
dynamic
equilibrium
between
symmetric
N3-amino
carbonyl-amino
geometries
protonated
C+•C
state.
