Review of light parameters and photobiomodulation efficacy: dive into complexity

Journal of Biomedical Optics, Journal Year: 2018, Volume and Issue: 23(12), P. 1 - 1

Published: Dec. 11, 2018

Photobiomodulation (PBM) therapy, previously known as low-level laser was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. Some groups have recommended use of a power density less 100 mW/cm2 an energy 4 to 10 J/cm2 at level target tissue. Others recommend much tissue surface. The wide range that can be applied (wavelength, energy, fluence, power, irradiance, pulse mode, treatment duration, repetition) in some cases has led contradictory results. In our review, we attempt evaluate effective ineffective PBM. Studies vitro with cultured cells or vivo different tissues were divided into those higher numbers mitochondria (muscle, brain, heart, nerve) lower (skin, tendon, cartilage). Graphs plotted against density. Although results showed high degree variability, cells/tissues tended respond doses light number mitochondria. Ineffective studies mitochondrial activity appeared often due over-dosing under-dosing.

Language: Английский

---

Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?

Photonics, Journal Year: 2019, Volume and Issue: 6(3), P. 77 - 77

Published: July 4, 2019

Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health problem facing Western world today. A large number of clinical trials have failed show any benefit tested drugs in stabilizing or reversing steady decline cognitive function that suffered by patients. Although pathological features AD consisting beta-amyloid plaques tau tangles are well established, considerable debate exists concerning genetic lifestyle factors predispose individuals developing dementia. Photobiomodulation (PBM) describes therapeutic use red near-infrared light stimulate healing, relieve pain inflammation, prevent tissue from dying. In recent years PBM has been applied for a diverse range brain disorders, frequently non-invasive manner shining on head (transcranial PBM). The present review discusses mechanisms action tPBM brain, summarizes studies used treat animal models AD. results limited patients with discussed.

Language: Английский

---

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Brain Research Bulletin, Journal Year: 2018, Volume and Issue: 144, P. 213 - 222

Published: Oct. 29, 2018

Language: Английский

---

Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model

Light Science & Applications, Journal Year: 2021, Volume and Issue: 10(1)

Published: Sept. 7, 2021

Abstract Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses cells tissues, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD), while its specific mechanisms have remained elusive. Here, we demonstrate that cognitive memory impairment an AD mouse model can be ameliorated 1070-nm via reducing cerebral β-amyloid (Aβ) burden, hallmark of AD. The glial cells, including microglia astrocytes, play important roles Aβ clearance. Our results show pulsed at 10 Hz triggers rather than astrocyte mice. light-induced with alteration morphology increased colocalization are sufficient reduce load Moreover, perivascular promote angiogenesis further enhance study confirms vessels use treatment mice provides framework developing novel approach

Language: Английский

---

Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(4), P. 2362 - 2373

Published: Jan. 18, 2024

Ginsenoside Rg1 (Rg1) is the main bioactive ginseng component. This study investigates effects of on cognitive deficits triggered by chronic sleep deprivation stress (CSDS) and explores its underlying mechanisms. effectively improved spatial working recognition memory, as evidenced various behavioral tests. RNA-sequence analysis revealed differential gene expression in metabolic pathway. Treatment with abrogated reductions SOD CAT activity, lowered MDA content, increased Nrf2 HO-1 protein levels. administration alleviated hippocampal mitochondrial dysfunction restoring normal ultrastructure enhancing ATP activities Mfn2 while regulating Drp-1 expression. mitigated neuronal apoptosis reducing Bax/Bcl-2 ratio levels cleaved caspase-3. Additionally, upregulated AMPK SIRT3 expressions. These findings suggest that has potential a robust intervention for associated deprivation, acting through modulation function, oxidative stress, apoptosis, AMPK-SIRT3 axis.

Language: Английский

---

Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This exerts multifaceted influences on neurons, blood vessels, their intricate interplay known neurovascular coupling (NVC). Growing evidence indicates NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. review aims elucidate potential metabolic pathways signaling cascades involved modulatory effects of PBM, while also exploring extensive repertoire applications neurologic psychiatric conditions. The prospects within realm investigation are intensively considered, providing deeper insights into powerful capabilities revolutionize treatments.

Language: Английский

---

Photobiomodulation and Coenzyme Q10 Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice

Frontiers in Cellular Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: March 19, 2019

Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) Coenzyme Q10 (CoQ10), administration are known to stimulate electron transport potentially may reverse effects of ischemia aged animals. We tested hypothesis PBM CoQ10, separately or combination improve cognition a mouse model superimposed on aging. modeled 6-week D-galactose (500 mg/kg/subcutaneous) mice. subsequently, induced bilateral occlusion common carotid artery (BCCAO). treated mice (810 nm transcranial laser) CoQ10 mg/kg; gavage), both, for two weeks after surgery. assessed function Barnes Lashley III mazes What-Where-Which (WWWhich) task. improved spatial episodic memory Separately together, treatments lowered reactive oxygen species, raised ATP general activity, as well biomarkers biogenesis, including SIRT1, PGC-1α, NRF1, TFAM. Neuroinflammatory responsiveness declined, indicated decreased iNOS, TNF-α, IL-1β levels treatments. Collectively, findings this preclinical study imply procognitive NIR treatments, combination, beneficial global brain

Language: Английский

---

Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102121 - 102121

Published: Nov. 8, 2023

Aging is widespread worldwide and a significant risk factor for cardiovascular disease (CVD). Mechanisms underlying aging have attracted considerable attention in recent years. Remarkably, CVD overlap numerous ways, with deregulated nutrient sensing as common mechanism lifestyle communal modifier. Interestingly, triggers or suppresses multiple nutrient-related signaling pathways. In this review, we first present the composition of nutrient-sensing network (NSN) its metabolic impact on CVD. Secondly, review how factors closely associated CVD, including adverse life states such sedentary behavior, sleep disorders, high-fat diet, psychosocial stress, contribute to focus bridging role NSN. Finally, positive effects beneficial dietary interventions, specifically restriction Mediterranean regulation metabolism delayed that depend balance summary, expound interaction between lifestyle, NSN, aging,

Language: Английский

---

<p>Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives</p>

Neuropsychiatric Disease and Treatment, Journal Year: 2019, Volume and Issue: Volume 15, P. 3255 - 3272

Published: Nov. 1, 2019

Abstract: Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well suicidal ideation and behavior. Current treatments for MDD have significant limitations in efficacy side effect burden. FDA-approved devices are burdensome (due to repeated in-office procedures) most suitable severely ill subjects. There critical need device-based that efficacious, well-tolerated, easy use. In this paper, we review novel neuromodulation strategy, transcranial photobiomodulation (t-PBM) near-infrared light (NIR). The scope our includes the known biological mechanisms t-PBM, its animal models depression patients MDD. Theoretically, t-PBM penetrates into cerebral cortex, stimulating mitochondrial respiratory chain, also significantly increases blood flow. Animal human studies, using variety settings experimental models, suggest may good tolerability aggregate, these data support large confirmatory studies novel, likely safe, easy-to-administer antidepressant treatment. Keywords: low-level therapy, photobiomodulation, near infrared radiation, major disorder,

Language: Английский

---

Transcranial near-infrared photobiomodulation could modulate brain electrophysiological features and attentional performance in healthy young adults

Lasers in Medical Science, Journal Year: 2019, Volume and Issue: 34(6), P. 1193 - 1200

Published: April 22, 2019

Language: Английский

---