The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 27, 2022

The prevalence of anxiety, mood and trauma- stress-related disorders are on the rise; however, efforts to develop new effective treatment strategies have had limited success. To identify novel therapeutic targets, a comprehensive understanding disease etiology is needed, especially in context holobiont, i.e., superorganism consisting human its microbiotas. Much emphasis has been placed role gut microbiota development, exacerbation, persistence psychiatric disorders; data for oral limited. cavity houses second most diverse microbial community body, with over 700 bacterial species that colonize soft hard tissues. Periodontal diseases encompass group infectious inflammatory affect periodontium. Among them, periodontitis defined as chronic, multi-bacterial infection elicits low-grade systemic inflammation via release pro-inflammatory cytokines, well local invasion long-distance translocation periodontal pathogens. Periodontitis can also induce or exacerbate other chronic such atherosclerosis diabetes lead adverse pregnancy outcomes. Recently, pathogens implicated pathophysiology neuropsychiatric (such depression schizophrenia), dysregulation immune system plays an integral these disorders. This review will discuss associated Epidemiological individuals be presented, followed by discussion microbiological immunological links between central nervous system. Pre-clinical clinical findings related phenotypes reviewed, bi-directionality oral-brain axis. Lastly, we focus target future interventions alleviate symptoms debilitating

Language: Английский

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A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2426 - 2426

Published: June 11, 2022

Over the last few decades, studies on oral microbiome have increased awareness that balance between host and microbial species coexist in it is essential for health at all stages of life. However, this extremely difficult to maintain, many factors can disrupt it: general eating habits, sugar consumption, tobacco smoking, hygiene, use antibiotics other antimicrobials. It now known alterations microbiota are responsible developing promoting diseases, including periodontal disease. In context, diet an area further investigation as has been observed intake particular foods, such farmed animal meat, dairy products, refined vegetable oils, processed cereals, affects composition microbiota, leading representation acid-producing acid-tolerant organisms pathogens. little about influence creation a suitable microenvironment development The aim present study evaluate current knowledge role dysbiosis underlying

Language: Английский

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Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 2, 2024

Abstract N6‐methyladenosine (m 6 A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role oral mucosal immunity remains ambiguous. Periodontitis a special but prevalent infectious disease characterized as hyperinflammation of mucosa bone resorption. Here, it reported that genetic deletion Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability TNFAIP3 (also known A20) transcript significantly attenuated upon m A modification. When silencing METTL3, accumulated functioning ubiquitin‐editing enzyme facilitates ubiquitination NEK7 [NIMA (never mitosis gene a)‐related kinase 7], subsequently impairs assembly. Furtherly, Coptisine chloride, natural small‐molecule, discovered novel METTL3 inhibitor performs therapeutic effect on periodontitis. The study unveils previously unknown pathogenic mechanism METTL3‐mediated modifications periodontitis indicates potential target.

Language: Английский

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PAMPs and DAMPs as the Bridge Between Periodontitis and Atherosclerosis: The Potential Therapeutic Targets

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Feb. 25, 2022

Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular inflammation, eventually leading to myocardial infarction stroke. Innate immunity plays an irreplaceable role in the inflammatory response triggered infection. Periodontitis common disorder that involves oral microbe-related bone loss local destruction of periodontal ligament risk factor for atherosclerosis. Periodontal pathogens contain numerous pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide, CpG DNA, Peptidoglycan, initiate innate depending on recognition pattern-recognition receptors (PRRs) host cells. The immune-inflammatory tissue will produce large number damage-associated (DAMPs) neutrophil extracellular traps (NETs), high mobility group box 1 (HMGB1), alarmins (S100 protein), which can further affect progression Molecular have recently become therapeutic targets disease, including blocking interaction between PRRs controlling related signal transduction pathway. This review summarized research progress some representative PAMPs DAMPs pathological mechanism bridging periodontitis We also discussed possible ways prevent serious cardiovascular events patients with atherosclerosis targeting patterns.

Language: Английский

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Periodontitis and coronavirus disease 2019

Periodontology 2000, Journal Year: 2022, Volume and Issue: 89(1), P. 207 - 214

Published: March 4, 2022

Abstract The coronavirus disease 2019 caused by severe acute respiratory syndrome 2 is usually a mild condition; however, in some cases it can result sickness and even death. Thus, understanding the reasons behind these grave outcomes of great importance. Coronavirus periodontitis share intriguing characteristics. They both lead to systemic inflammation alterations coagulation pathways, confounding factors, such as diabetes, hypertension, obesity. Accordingly, possible association between conditions has been hypothesized literature. objective this review was evaluate scientific evidence linking diseases underlying mechanisms. Evidence shown that presents oral manifestations affect periodontal tissues. Moreover, studies have severity presence periodontitis. Current suggests could be explained through direct role bacteria aggravating lung infections, well indirect effect inducing priming immune system an exacerbated reaction infection. Future research needed confirm observations explore care might play pandemic.

Language: Английский

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The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 5456 - 5456

Published: May 21, 2021

During the last few decades, it has been established that messenger ribonucleic acid (mRNA) transcription does not inevitably lead to protein translation, but there are numerous processes involved in post-transcriptional regulation, which is a continuously developing field of research. MicroRNAs (miRNAs) group small non-coding RNAs, negatively regulate expression and implicated several physiological pathological mechanisms. Aberrant miRNAs triggers dysregulation multiple cellular innate adaptive immune responses. For many years, was thought acted only within cell they were synthesised, but, recently, have found outside cells bound lipids proteins, or enclosed extracellular vesicles, namely exosomes. They can circulate throughout body, transferring information between altering gene recipient cells, as fuse with be internalised by cells. Numerous studies on conducted order identify possible biomarkers used diagnosis periodontal disease. However, therapeutic agents, single target genes influence regulatory networks. The aim this review examine molecular role exosomes pathophysiology disease evaluate clinical future implications for personalised therapeutical approach.

Language: Английский

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Does high sugar intake really alter the oral microbiota?: A systematic review

Clinical and Experimental Dental Research, Journal Year: 2022, Volume and Issue: 8(6), P. 1376 - 1390

Published: Aug. 9, 2022

Abstract Objectives Diet is one of the main factors influencing diversity and interactions oral microbiota. The purpose this study to determine impact sugar intake on microbial bacteria that predominate under these conditions. Material Methods A systematic review was conducted according Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA) guide, using PubMed, Scopus, Science Direct databases combinations words “microbiota,” “microbiology,” “bacteria,” “sugars,” “dysbiosis,” “caries,” “microbiome,” “oral microbial,” microbiota profile pattern.” selection criteria included year, language, type publication, comparison during low high intake, bacterial identification by molecular sequencing 16S subunit ribosomal RNA. Results Out a total 374 papers came up after initial search, 8 met review. research populations comprising children, young adults, with most studies reporting participants validated instruments intake. Apart from study, all others reported conditions significant decrease in microbiome predominance several genera or species, including Streptococcus , Scardovia Veillonella Rothia Actinomyces Lactobacillus . Conclusions Sugar‐rich diets have significantly unfavorable effect balance microbiota; however, further are required exact role interactions.

Language: Английский

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The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis

International Journal of Medical Sciences, Journal Year: 2022, Volume and Issue: 19(10), P. 1603 - 1614

Published: Jan. 1, 2022

Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even leads to tooth loss.NLRP3 inflammasomes play critical role in periodontitis pathogenesis.Aberrant activation or overexpression of NLRP3 cellular players, including osteoclasts, osteoblasts, periodontal ligament fibroblasts, leukocytes often contributes dysfunction environment abnormality, thus resulting the disorganization alveolar bone.In this review, we mainly focus on negative regulation inflammasome highlight importance as candidate therapeutic target treatment.Then elucidate development status inhibitors show their application potential for treating periodontitis.In summary, review reveals recent progress perspectives periodontitis.

Language: Английский

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A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization

Experimental Cell Research, Journal Year: 2022, Volume and Issue: 418(1), P. 113264 - 113264

Published: June 15, 2022

Language: Английский

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The association between dietary vitamin C intake and periodontitis: result from the NHANES (2009–2014)

BMC Oral Health, Journal Year: 2022, Volume and Issue: 22(1)

Published: Sept. 8, 2022

Abstract Background The purpose of this study was to investigate whether periodontitis is associated with dietary vitamin C intake, using data from National Health and Nutrition Examination Survey (NHANES) 2009–2014. Methods included 5145 adults (age ≥ 30 years) as a dichotomous variable daily intake continuous variable. Multiple sets covariates, such age, sex, number flossing, etc., were selected. Using EmpowerStats version 3.0, multivariate logistic regression analysis hierarchical performed on the data, curve fitting graphs made. Results There no statistically significant differences ( P > 0.05) between four groups (quartiles, Q1–Q4) covariates (drinking alcohol hypertension). low VC group (Q1) more prone than Q2, Q3, Q4 (all OR < 1.00). A threshold nonlinear association found (mg) log10 transformation in generalized additive model (GAM) = 0.01). Conclusion relationship likelihood non-linear. smallest index occurred when 158.49 mg. Too little or too much increases periodontitis.

Language: Английский

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