Periodontology 2000,
Journal Year:
2022,
Volume and Issue:
90(1), P. 106 - 124
Published: Aug. 1, 2022
Abstract
Mental
health
disorders,
particularly
depression
and
anxiety,
affect
a
significant
number
of
the
global
population.
Several
pathophysiological
pathways
for
these
disorders
have
been
identified,
including
hypothalamic‐pituitary‐adrenal
axis,
autonomic
nervous
system,
immune
system.
In
addition,
life
events,
environmental
factors,
lifestyle
onset,
progression,
recurrence
mental
disorders.
These
may
all
overlap
with
periodontal
and/or
peri‐implant
disease.
are
associated
more
severe
disease
and,
in
some
cases,
poorer
healing
outcomes
to
nonsurgical
therapy.
They
can
result
behavior
modification,
such
as
poor
oral
hygiene
practices,
tobacco
smoking,
alcohol
abuse,
which
also
risk
factors
therefore,
contributory
effect.
Stress
has
immunomodulatory
effects
regulating
cell
numbers
function,
well
proinflammatory
cytokine
production.
markers
cortisol
catecholamines
modulate
bacterial
growth
expression
virulence
factors.
accompanied
by
low‐grade
chronic
inflammation
that
be
involved
their
relationship
vice
versa.
Although
gut
microbiome
interacting
central
system
(gut‐brain
axis)
is
thought
play
role
illness,
less
understood
about
microbiome.
The
evidence
on
implant
lacking,
but
mainly
through
behaviourial
changes.
Through
lack
compliance
withoral
maintenance
visits,
affected.
Increased
smoking
outcomes.
Selective
serotonin
reuptake
inhibitors
linked
higher
failure.
an
anabolic
effect
bone,
reducing
turnover,
could
account
increased
loss.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Clinical Implant Dentistry and Related Research,
Journal Year:
2022,
Volume and Issue:
25(4), P. 640 - 660
Published: Dec. 19, 2022
Abstract
Background
Strong
evidence
suggests
the
infectious
nature
of
peri‐implant
diseases
occurring
in
susceptible
hosts.
Epidemiological
reports,
though,
indicate
that
peri‐implantitis
is
a
site‐specific
entity.
Hence,
significance
local
factors
may
predispose/precipitate
plaque
accumulation
and
impact
systemic
drivers
alter
immune
response
are
relevant
prevention
management
disorders.
Purpose
The
purpose
present
review
to
shed
light
on
diseases,
making
special
emphasis
associations
with
peri‐implantitis.
Methods
biologic
plausibility
supporting
aiming
at
providing
concluding
remark
were
explored
recent
scientific
literature
for
predisposing/precipitating
related
diseases.
Results
Local
predisposing
such
as
soft
tissue
characteristics,
implant
position
prosthetic
design
proved
being
strongly
associated
occurrence
Hard
however,
failed
demonstrate
having
direct
association
Robust
data
points
toward
strong
link
between
residual
sub‐mucosal
cement
while
limited
floss
Systemic
drivers/habits
hyperglycemia
smoking
showed
negative
However,
there
insufficient
claim
any
metabolic
syndrome,
atherosclerotic
cardiovascular
disease,
obesity
Conclusion
increase
risk
Therefore,
comprehensive
anamnesis
patients,
educational/motivational
programs
exhaustive
prosthetically‐driven
treatment
planning
must
be
fostered
reducing
rate
biological
complications
dentistry.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Jan. 18, 2023
The
prevalence
of
anxiety
and
depression
soared
following
the
COVID-19
pandemic.
To
effectively
treat
these
conditions,
a
comprehensive
understanding
all
etiological
factors
is
needed.
This
study
investigated
fecal
microbial
features
associated
with
mental
health
outcomes
(symptoms
anxiety,
depression,
or
posttraumatic
stress
disorder
(PTSD))
in
Spanish
cohort
aftermath
Microbial
communities
from
stool
samples
were
profiled
198
individuals
who
completed
validated,
self-report
questionnaires.
16S
ribosomal
RNA
gene
V3-4
amplicon
sequencing
was
performed.
diversity
community
structure
analyzed,
together
relative
taxonomic
abundance.
In
our
N=198,
17.17%
reported
depressive
symptoms,
37.37%
state
40.90%
trait
8.08%
PTSD
high
levels
comorbidity.
Individuals
had
lower
Simpson's
diversity.
Fusicatenibacter
saccharivorans
reduced
comorbid
+
whilst
an
expansion
Proteobacteria
depletion
Synergistetes
phyla
noted
symptoms.
abundance
Anaerostipes
positively
correlated
childhood
trauma,
higher
Turicibacter
sanguinis
Lentisphaerae
found
experienced
life-threatening
traumas.
infection
vaccination
influenced
overall
composition
distinct
profiles.
These
findings
will
help
lay
foundation
for
future
studies
to
identify
role
players
symptoms
provide
therapeutic
targets
improve
outcomes.
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(3), P. 1267 - 1325
Published: Jan. 16, 2024
Neuropsychiatric
disorders
denote
a
broad
range
of
illnesses
involving
neurology
and
psychiatry.
These
include
depressive
disorders,
anxiety,
schizophrenia,
bipolar
disorder,
attention
deficit
hyperactivity
autism
spectrum
headaches,
epilepsy.
In
addition
to
their
main
neuropathology
that
lies
in
the
central
nervous
system
(CNS),
lately,
studies
have
highlighted
role
immunity
neuroinflammation
neuropsychiatric
disorders.
Toll-like
receptors
(TLRs)
are
innate
act
as
bridge
between
adaptive
immune
systems
via
adaptor
proteins
(e.g.,
MYD88)
downstream
elements;
TLRs
classified
into
13
families
involved
normal
function
CNS.
expression
affects
course
is
influenced
during
pharmacotherapy;
For
example,
multiple
normalized
major
disorder
pharmacotherapy.
Here,
neuroimmunology,
treatment,
management
discussed.
We
recommend
longitudinal
comparatively
assess
cell-type-specific
illness
progression,
remission.
Also,
further
research
should
explore
molecular
insights
regulation
related
pathways.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
With
the
global
population
aging,
awareness
of
oral
health
is
rising.
Periodontitis,
a
widespread
bacterial
infectious
disease,
gaining
attention.
Current
novel
biomaterials
address
key
clinical
issues
like
infection,
gum
inflammation,
tooth
loosening,
and
loss,
focusing
on
antibacterial,
anti-inflammatory,
tissue
regeneration
properties.
However,
strategies
that
integrate
advantages
these
to
achieve
synergistic
therapeutic
effects
by
clearing
biofilms,
inhibiting
inflammation
activation,
restoring
periodontal
soft
hard
functions
remain
very
limited.
Recent
studies
highlight
link
between
periodontitis
systemic
diseases,
underscoring
complexity
disease.
There
an
urgent
need
find
comprehensive
treatment
plans
requirements.
Whether
integrating
new
enhance
existing
treatments
or
developing
approaches
replace
traditional
therapies,
efforts
will
drive
advancements
in
treatment.
Therefore,
this
review
compares
with
treatments.
It
highlights
design
concepts
mechanisms
functional
materials,
their
properties,
discusses
importance
strategies.
This
aims
provide
guidance
for
emerging
research
promote
development
precise
efficient
mLife,
Journal Year:
2024,
Volume and Issue:
3(3), P. 367 - 383
Published: Sept. 1, 2024
Abstract
The
oral
cavity
contains
the
second‐largest
microbiota
in
human
body.
cavity's
anatomically
and
physiologically
diverse
niches
facilitate
a
wide
range
of
symbiotic
bacteria
living
at
distinct
sites.
Consequently,
exhibits
site
specificity,
with
species,
compositions,
structures
influenced
by
specific
aspects
their
placement.
Variations
structure
caused
changes
these
influencing
factors
can
impact
overall
health
lead
to
development
diseases—not
only
but
also
organs
distal
mouth—such
as
cancer,
cardiovascular
disease,
respiratory
disease.
Conversely,
diseases
exacerbate
imbalance
microbiota,
creating
vicious
cycle.
Understanding
heterogeneity
both
microbiome
individual
humans
is
important
for
investigating
causal
links
between
diseases.
Additionally,
understanding
intricacies
microbiome's
composition
regulatory
will
help
identify
potential
causes
related
develop
interventions
prevent
treat
illnesses
this
domain.
Therefore,
turning
extant
research
field,
we
systematically
review
relationship
dynamics
Medicine,
Journal Year:
2024,
Volume and Issue:
103(27), P. e38630 - e38630
Published: July 5, 2024
Dental
infections,
which
include
anything
from
severe
periodontal
illnesses
and
abscess
forms
to
routine
tooth
caries,
are
a
major
public
health
risk.
This
review
article
focuses
on
the
pathophysiology
treatment
of
dental
infections.
A
narrative
was
conducted
based
several
published
articles,
relevant
journals,
books
in
Google
Scholar
PubMed
using
keywords
disease,
gingivitis,
related
diseases;
we
excluded
duplicated
information.
Our
illustrated
types
infections
proper
antimicrobial
drug
that
is
suitable
for
this
disease.
Drawing
recent
research
findings
clinical
evidence,
explore
spectrum
bacteria
commonly
associated
with
their
susceptibility
profiles
various
antibiotics.
Emphasis
placed
understanding
mechanisms
antibiotic
action
resistance
context
pathogens,
shedding
light
optimal
regimens
potential
challenges
management.
Additionally,
go
over
consequences
therapy
dentistry,
taking
into
account
factors
like
patient
selection,
dose
guidelines,
side
effects.
The
management
through
strategies
has
undergone
significant
advancements,
as
evidenced
by
updated
review.
Besides
normal
methods,
emerging
technologies
such
3D
printing
delivery
antibiotics
disinfectants
hold
promise
enhancing
efficacy
outcomes.
By
leveraging
precision
customization
afforded
printing,
dentistry
can
tailor
interventions
individual
needs,
optimizing
therapeutic
outcomes
while
minimizing
adverse
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
37(2)
Published: Oct. 10, 2024
Abstract
The
healing
of
bone
defects
after
debridement
in
medication‐related
osteonecrosis
the
jaw
(MRONJ)
is
a
challenging
medical
condition
with
impaired
angiogenesis,
susceptible
infection,
and
pro‐inflammatory
responses.
Magnesium
(Mg)
nanocomposite
hydrogel
developed
to
specifically
tackle
multiple
factors
involved
MRONJ.
Mg‐oxide
nanoparticles
tune
gelation
kinetics
reaction
between
N‐hydroxysuccinimide‐functionalized
hyperbranched
poly
(ethylene
glycol)
proteins.
This
allows
an
enhanced
mechanical
property
instant
solidification
and,
more
importantly,
also
stable
environments
such
as
wet
hemorrhagic
conditions.
synthesized
guides
mandible
regeneration
MRONJ
rats
by
triggering
formation
type
H
vessels,
activating
Osterix+
osteoprogenitor
cells,
generating
anti‐inflammatory
microenvironments.
Additionally,
this
approach
demonstrates
its
ability
suppress
infection
inhibiting
specific
pathogens
while
strengthening
stress
tolerance
affected
alveolar
bone.
Furthermore,
osteogenic
properties
feasibility
implantation
are
validated
defect
iliac
crest
created
minipigs,
respectively.
Collectively,
study
offers
injectable
innovative
substitute
enhance
tackling
detrimental
pathologies.
