Alginate and alginate composites for biomedical applications

Asian Journal of Pharmaceutical Sciences, Journal Year: 2020, Volume and Issue: 16(3), P. 280 - 306

Published: Nov. 5, 2020

Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and capsule of bacteria such as Azotobacter sp. Pseudomonas Owing to alginate gel forming capability, it widely used food, textile paper industries; a lesser extent biomedical applications biomaterial promote wound healing tissue regeneration. This evident from rising use alginate-based dressing for heavily exuding their mass availability market nowadays. However, also has limitation. When contact with physiological environment, could gelate into softer structure, consequently limits its potential soft regeneration becomes inappropriate usage related load bearing body parts. To cater this problem, wide range materials have been added producing sturdy composite materials. For instance, incorporation adhesive peptide natural polymer or synthetic moieties creates improved material, which not only possesses better mechanical properties compared native alginate, but grants additional capability In addition, drug release kinetic cell viability can be further when encapsulating agent. review, preparation various forms (fibre, bead, hydrogel, 3D-printed matrices) application described first, followed by discussion latest trend utilization dressing, delivery, engineering applications.

Language: Английский

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Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 22, 2019

Photodynamic therapy (PDT) has shown the potential of triggering systemic antitumor immune responses. However, while oxygen-deficient hypoxic tumor microenvironment is a factor that limits PDT efficacy, responses after conventional usually are not strong enough to eliminate metastatic tumors. Herein, light-triggered in situ gelation system containing photosensitizer-modified catalase together with poly(ethylene glycol) double acrylate (PEGDA) as polymeric matrix designed. Immune adjuvant nanoparticles further introduced into this trigger robust PDT. Following local injection mixed precursor solution tumors and subsequent light exposure, polymerization PEGDA can be initiated induce gelation. Such hybrid hydrogel long-term retention various agents ability enable persistent hypoxia relief multiple rounds PDT, which results significantly enhanced by multiround stimulation. Further combination such gel-based anticytotoxic T-lymphocyte antigen-4 checkpoint blockade offers only abscopal effect inhibit growth distant but also effective memory protection from rechallenged Therefore, single-dose greatly photoimmunotherapy means repeated stimulations.

Language: Английский

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Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11149 - 11193

Published: June 30, 2021

Owing to their unique chemical and physical properties, hydrogels are attracting increasing attention in both basic translational biomedical studies. Although the classical with static networks have been widely reported for decades, a growing number of recent studies shown that structurally dynamic can better mimic dynamics functions natural extracellular matrix (ECM) soft tissues. These synthetic materials defined compositions recapitulate key biophysical properties living tissues, providing an important means understanding mechanisms by which cells sense remodel surrounding microenvironments. This review begins overall expectation design principles hydrogels. We then highlight progress fabrication strategies including degradation-dependent degradation-independent approaches, followed use applications such as regenerative medicine, drug delivery, 3D culture. Finally, challenges emerging trends development application discussed.

Language: Английский

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Recent advances of injectable hydrogels for drug delivery and tissue engineering applications

Polymer Testing, Journal Year: 2019, Volume and Issue: 81, P. 106283 - 106283

Published: Dec. 9, 2019

Language: Английский

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Physically cross-linked chitosan-based hydrogels for tissue engineering applications: A state-of-the-art review

European Polymer Journal, Journal Year: 2021, Volume and Issue: 145, P. 110176 - 110176

Published: Jan. 17, 2021

Language: Английский

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Coadministration of an Adhesive Conductive Hydrogel Patch and an Injectable Hydrogel to Treat Myocardial Infarction

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 12(2), P. 2039 - 2048

Published: Dec. 20, 2019

Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels and epicardial biomaterial patches, have been pursued to treat myocardial infarction. However, only limited therapeutic efficacy is achieved with a single means. Here, combined therapy approach proposed, that is, coadministration of conductive hydrogel patch infarcted myocardium. The self-adhesive fabricated based on Fe3+-induced ionic coordination between dopamine-gelatin (GelDA) conjugates dopamine-functionalized polypyrrole (DA-PPy), which form homogeneous network. cleavable formed in situ via Schiff base reaction oxidized sodium hyaluronic acid (HA-CHO) hydrazided (HHA). Compared single-mode system, injecting HA-CHO/HHA intramyocardially followed by painting GelDA/DA-PPy heart surface results more pronounced improvement cardiac function terms echocardiographical, histological, angiogenic outcomes.

Language: Английский

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Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field

Cancers, Journal Year: 2021, Volume and Issue: 13(5), P. 1164 - 1164

Published: March 9, 2021

Cancer remains as the second leading cause of death, worldwide. Despite enormous important advances observed in last decades, advanced stages disease remain incurable. The severe side effects associated to systemic high doses chemotherapy and development drug resistance impairs a safe efficiency anticancer therapy. Therefore, new formulations are continuously under research improve drugs therapeutic index through localized delivery at tumor sites. Among wide range possibilities, hydrogels have recently gained special attention due their potential allow situ sustained controlled release. In particular, stimuli-responsive which able change physical state from liquid gel accordingly external factors such temperature, pH, light, ionic strength, magnetic field, among others. Some these presented promising results for control treatment cancer. present work aims discuss main properties application cancer summarize most decades focusing on use pH-, light-, strength-, magnetic-responsive hydrogels.

Language: Английский

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Rational Design of Smart Hydrogels for Biomedical Applications

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 8

Published: Feb. 4, 2021

Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. categorized by composition from natural polymers synthetic polymers. To meet complicated situation applications, suitable host–guest supramolecular interactions rationally selected. This review will have an introduction of hydrogel classification based on formulation molecules, then discussion over rational design intelligent environmental stimuli such as temperature, irradiation, pH, targeted biomolecules. Further, applications designed smart field be presented, tissue repair, drug delivery, cancer therapy. Finally, perspectives challenges outlined.

Language: Английский

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Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 29, 2022

Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel (Gel) increased their joint thereby playing role on STOA due mechanical instability established by transecting lateral ligaments (anterior talofibular ligament (ATFL)/calcaneal fibular (CFL)). incorporated Gel (Exo-Gel) system, composed Poloxamer-407 188 mixture-based thermoresponsive matrix an optimal ratio, determined release ability Exo rheology response different temperature. The biological activity Exo-Gel evaluated vitro, effect vivo. released from continuously 28 days could promote proliferation migration mouse bone mesenchymal stem cells (mBMSCs) chondrocytes, at same time enhance chondrogenic differentiation mBMSCs, inhibit inflammation-induced chondrocyte degeneration. In vivo experiments confirmed that local Exo, inhibited apoptosis hypertrophy enhanced proliferation, potentially played cell recruitment delay development STOA. Thus, Delivery provides novel approach cell-free therapy has

Language: Английский

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A ROS‐Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro‐Angiogenesis for Efficient Treatment of Myocardial Infarction

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(19)

Published: July 18, 2022

Abstract Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis early myocardial infarction (MI). However, only few agents or strategies have developed to improve mitochondrial for the effective MI treatment. Herein, reactive oxygen species (ROS)‐responsive PAMB‐G‐TK/4‐arm‐PEG‐SG hydrogel is localized drug‐loaded liposome delivery. Notably, liposomes contain both elamipretide (SS‐31) and sphingosine‐1‐phosphate (S1P), where SS‐31 acts an inhibitor oxidative damage S1P signaling molecule activating angiogenesis. Liposome‐encapsulated hydrogels demonstrate myocardium‐like mechanical strength electrical conductivity, ROS‐sensitive release S1P‐loaded liposomes. Further liposomal SS‐31, which can target cytochrome c in inner membrane damaged CMs, inhibits pathological ROS production, improving dysfunction. Meanwhile, released from induces endothelial cell angiogenesis by S1PR1/PI3K/Akt pathway. In rat model, resulting composite improves cardiac function scavenging excess ROS, dysfunction, promoting This study reports first time that directly mitochondria CMs feedback‐regulated encapsulated consume overproduced improved CM activity enhanced

Language: Английский

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