Relationship between Structure and Rheology of Hydrogels for Various Applications

Gels, Journal Year: 2021, Volume and Issue: 7(4), P. 255 - 255

Published: Dec. 9, 2021

Hydrogels have gained a lot of attention with their widespread use in different industrial applications. The versatility the synthesis and nature precursor reactants allow for varying range hydrogels mechanical rheological properties. Understanding behavior relationship between chemical structure resulting properties is crucial, focus this review. Specifically, we include detailed discussion on correlation characteristics possible Different tests such as time, temperature frequency sweep, among others, are described results those reported. most prevalent applications also discussed.

Language: Английский

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Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Materials Today Bio, Journal Year: 2021, Volume and Issue: 13, P. 100186 - 100186

Published: Dec. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Language: Английский

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Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11149 - 11193

Published: June 30, 2021

Owing to their unique chemical and physical properties, hydrogels are attracting increasing attention in both basic translational biomedical studies. Although the classical with static networks have been widely reported for decades, a growing number of recent studies shown that structurally dynamic can better mimic dynamics functions natural extracellular matrix (ECM) soft tissues. These synthetic materials defined compositions recapitulate key biophysical properties living tissues, providing an important means understanding mechanisms by which cells sense remodel surrounding microenvironments. This review begins overall expectation design principles hydrogels. We then highlight progress fabrication strategies including degradation-dependent degradation-independent approaches, followed use applications such as regenerative medicine, drug delivery, 3D culture. Finally, challenges emerging trends development application discussed.

Language: Английский

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Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 10(1)

Published: Oct. 18, 2020

Abstract Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications minimally invasive local drug delivery, more precise implantation, and site‐specific delivery into poorly reachable tissue sites interface tissues, where wound healing takes a long time. hydrogels, such as situ forming and/or shear‐thinning can be generated using chemically physically crosslinked hydrogels. Yet, for controlled applications, ideal injectable hydrogel should able provide sustained release of molecules target site when needed limit nonspecific molecule distribution healthy tissues. Thus, sense environmental changes that arise disease states optimal amount over necessary time period region. To address this, researchers designed stimuli‐responsive Stimuli‐responsive change shape or volume they stimuli, e.g., pH, temperature, light, electrical signals, enzymatic changes, deliver an concentration drugs without affecting

Language: Английский

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Smart Hydrogels for Advanced Drug Delivery Systems

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3665 - 3665

Published: March 27, 2022

Since the last few decades, development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from environments, has become a thriving research frontier in biomedical engineering field. Nowadays, drug delivery systems have received great attention hydrogels be potentially used these due high stability, physicochemical properties, biocompatibility. Smart change hydrophilicity, swelling ability, physical molecules permeability, influenced by such as pH, temperature, electrical magnetic fields, light, biomolecules' concentration, thus resulting controlled release loaded drugs. Herein, this review encompasses latest investigations field stimuli-responsive drug-loaded our contribution matter.

Language: Английский

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Biomedical applications of hydrogels in drug delivery system: An update

Journal of Drug Delivery Science and Technology, Journal Year: 2021, Volume and Issue: 66, P. 102914 - 102914

Published: Oct. 14, 2021

Language: Английский

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Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Bone Research, Journal Year: 2021, Volume and Issue: 9(1)

Published: March 16, 2021

Abstract Bone tumors, especially those in osteosarcoma, usually occur adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, resection often fails to completely remove the tumor, which is main cause of postoperative recurrence metastasis, resulting a high mortality rate. Moreover, bone tumors invade large areas bone, cannot repair itself, causes serious effect on quality life patients. Thus, tumor therapy regeneration are challenging clinic. Herein, this review presents recent developments bifunctional biomaterials achieve new strategy for selected materials include 3D-printed scaffolds, nano/microparticle-containing hydrogels, bone-targeting nanomaterials. Numerous related studies combining photothermal with enhanced were reviewed. Finally, perspective future development tissue engineering discussed. This will provide useful reference tumor-related disease field complex diseases combine engineering.

Language: Английский

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Injectable Hydrogels: From Laboratory to Industrialization

Polymers, Journal Year: 2021, Volume and Issue: 13(4), P. 650 - 650

Published: Feb. 22, 2021

The transfer of some innovative technologies from the laboratory to industrial scale is many times not taken into account in design and development functional materials such as hydrogels be applied biomedical field. There a lack knowledge scientific field where aspects scaling an process are ignored, products cannot reach market. Injectable good example that we have used our research show different steps needed follow get product market based on them. From synthesis validation characterization techniques assays performed ensure safety efficacy product, following regulation, several well-defined protocols must adopted. Therefore, this paper summarized all these due exists about industrialization injectable with great importance it entails, intended serve guide area non-initiated scientists. More concretely, work, characteristics requirements for presented terms (i) employed obtain tunable desired properties, (ii) most common characterize hydrogels, (iii) necessary industrialize commercialize regulatory point view. Finally, review also mentioned explained real natural hyaluronic acid hydrogel reached product.

Language: Английский

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Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Macromolecular Rapid Communications, Journal Year: 2021, Volume and Issue: 42(10)

Published: April 20, 2021

Abstract Injectable hydrogel possesses great application potential in disease treatment and tissue engineering, but damage to gel often occurs due the squeezing pressure from injection devices mechanical forces limb movement, leads rapid degradation of matrix leakage load material. The self‐healing injectable hydrogels can overcome these drawbacks via automatically repairing structural defects restoring function. polysaccharide constructed through Schiff base reaction own advantages including simple fabrication, injectability, under physiological conditions, therefore have drawn extensive attention investigation recently. In this short review, preparation properties that is established on are focused their biological applications drug delivery cell therapy discussed.

Language: Английский

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Recent advances in responsive hydrogels for diabetic wound healing

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100508 - 100508

Published: Nov. 30, 2022

Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.

Language: Английский

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