International Journal of Polymeric Materials,
Journal Year:
2020,
Volume and Issue:
70(8), P. 574 - 584
Published: March 19, 2020
Hydrogels
are
basically
three-dimensional
network
structures
which
formulated
from
specific
natural
and
synthetic
polymers.
They
have
the
ability
to
absorb
carry
sufficient
quantity
of
water
in
their
porous
structure.
can
be
as
well
The
characteristics
an
ideal
hydrogel
good
permeability,
biocompatibility,
flexibility
viscoelasticity.
There
numerous
technologies
method
preparation
for
hydrogels
briefly
discussed
this
review.
various
routes
drug
delivery
into
body
including
oral,
rectal,
ocular,
subcutaneous,
vaginal
transdermal
routes.
suitable
candidates
they
biocompatible
also
degraded
when
made
bio
degradable
Now-a-days
extensively
used
delivery.
much
biomedical
pharmaceutical
application,
among
is
remarkable.
formulation
hydrogel-based
patch
has
recently
gained
importance
because
its
unique
properties.
mostly
synthesized
hydrophilic
polymers
capacity
hold
substantial
amount
ranging
10-20%
may
goes
up
1000's
times
dry
weight.
This
plays
important
role
skin
elasticity
moisturization
making
them
dosage
form
topical
use.
In
review,
we
described
hydrogels,
types
classification,
characteristics,
preparation,
different
monomers
formulation,
applications
fields
particularly
elaborated.
Gels,
Journal Year:
2021,
Volume and Issue:
7(4), P. 255 - 255
Published: Dec. 9, 2021
Hydrogels
have
gained
a
lot
of
attention
with
their
widespread
use
in
different
industrial
applications.
The
versatility
the
synthesis
and
nature
precursor
reactants
allow
for
varying
range
hydrogels
mechanical
rheological
properties.
Understanding
behavior
relationship
between
chemical
structure
resulting
properties
is
crucial,
focus
this
review.
Specifically,
we
include
detailed
discussion
on
correlation
characteristics
possible
Different
tests
such
as
time,
temperature
frequency
sweep,
among
others,
are
described
results
those
reported.
most
prevalent
applications
also
discussed.
Materials Today Bio,
Journal Year:
2021,
Volume and Issue:
13, P. 100186 - 100186
Published: Dec. 9, 2021
Recently,
biomedicine
and
tissue
regeneration
have
emerged
as
great
advances
that
impacted
the
spectrum
of
healthcare.
This
left
door
open
for
further
improvement
their
applications
to
revitalize
impaired
tissues.
Hence,
restoring
functions.
The
implementation
therapeutic
protocols
merge
biomimetic
scaffolds,
bioactive
molecules,
cells
plays
a
pivotal
role
in
this
track.
Smart/stimuli-responsive
hydrogels
are
remarkable
three-dimensional
(3D)
bioscaffolds
intended
engineering
other
biomedical
purposes.
They
can
simulate
physicochemical,
mechanical,
biological
characters
innate
Also,
they
provide
aqueous
conditions
cell
growth,
support
3D
conformation,
mechanical
stability
cells,
serve
potent
delivery
matrices
molecules.
Many
natural
artificial
polymers
were
broadly
utilized
design
these
intelligent
platforms
with
novel
advanced
characteristics
tailored
functionalities
fit
such
applications.
In
present
review,
we
highlighted
different
types
smart/stimuli-responsive
emphasis
on
synthesis
scheme.
Besides,
mechanisms
responsiveness
stimuli
elaborated.
Their
potential
was
discussed.
Furthermore,
exploitation
targeted
drug
delivery,
smart
biosensors,
actuators,
4D
printing,
culture
outlined.
addition,
threw
light
self-healing
biomedicine.
Eventually,
presented
future
perceptions
Conclusively,
current
progress
enhances
prospective
function
intelligent,
sophisticated
systems
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(18), P. 11149 - 11193
Published: June 30, 2021
Owing
to
their
unique
chemical
and
physical
properties,
hydrogels
are
attracting
increasing
attention
in
both
basic
translational
biomedical
studies.
Although
the
classical
with
static
networks
have
been
widely
reported
for
decades,
a
growing
number
of
recent
studies
shown
that
structurally
dynamic
can
better
mimic
dynamics
functions
natural
extracellular
matrix
(ECM)
soft
tissues.
These
synthetic
materials
defined
compositions
recapitulate
key
biophysical
properties
living
tissues,
providing
an
important
means
understanding
mechanisms
by
which
cells
sense
remodel
surrounding
microenvironments.
This
review
begins
overall
expectation
design
principles
hydrogels.
We
then
highlight
progress
fabrication
strategies
including
degradation-dependent
degradation-independent
approaches,
followed
use
applications
such
as
regenerative
medicine,
drug
delivery,
3D
culture.
Finally,
challenges
emerging
trends
development
application
discussed.
Advanced Healthcare Materials,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Oct. 18, 2020
Abstract
Injectable
hydrogels
have
received
considerable
interest
in
the
biomedical
field
due
to
their
potential
applications
minimally
invasive
local
drug
delivery,
more
precise
implantation,
and
site‐specific
delivery
into
poorly
reachable
tissue
sites
interface
tissues,
where
wound
healing
takes
a
long
time.
hydrogels,
such
as
situ
forming
and/or
shear‐thinning
can
be
generated
using
chemically
physically
crosslinked
hydrogels.
Yet,
for
controlled
applications,
ideal
injectable
hydrogel
should
able
provide
sustained
release
of
molecules
target
site
when
needed
limit
nonspecific
molecule
distribution
healthy
tissues.
Thus,
sense
environmental
changes
that
arise
disease
states
optimal
amount
over
necessary
time
period
region.
To
address
this,
researchers
designed
stimuli‐responsive
Stimuli‐responsive
change
shape
or
volume
they
stimuli,
e.g.,
pH,
temperature,
light,
electrical
signals,
enzymatic
changes,
deliver
an
concentration
drugs
without
affecting
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(7), P. 3665 - 3665
Published: March 27, 2022
Since
the
last
few
decades,
development
of
smart
hydrogels,
which
can
respond
to
stimuli
and
adapt
their
responses
based
on
external
cues
from
environments,
has
become
a
thriving
research
frontier
in
biomedical
engineering
field.
Nowadays,
drug
delivery
systems
have
received
great
attention
hydrogels
be
potentially
used
these
due
high
stability,
physicochemical
properties,
biocompatibility.
Smart
change
hydrophilicity,
swelling
ability,
physical
molecules
permeability,
influenced
by
such
as
pH,
temperature,
electrical
magnetic
fields,
light,
biomolecules'
concentration,
thus
resulting
controlled
release
loaded
drugs.
Herein,
this
review
encompasses
latest
investigations
field
stimuli-responsive
drug-loaded
our
contribution
matter.
Bone Research,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: March 16, 2021
Abstract
Bone
tumors,
especially
those
in
osteosarcoma,
usually
occur
adolescents.
The
standard
clinical
treatment
includes
chemotherapy,
surgical
therapy,
and
radiation
therapy.
Unfortunately,
resection
often
fails
to
completely
remove
the
tumor,
which
is
main
cause
of
postoperative
recurrence
metastasis,
resulting
a
high
mortality
rate.
Moreover,
bone
tumors
invade
large
areas
bone,
cannot
repair
itself,
causes
serious
effect
on
quality
life
patients.
Thus,
tumor
therapy
regeneration
are
challenging
clinic.
Herein,
this
review
presents
recent
developments
bifunctional
biomaterials
achieve
new
strategy
for
selected
materials
include
3D-printed
scaffolds,
nano/microparticle-containing
hydrogels,
bone-targeting
nanomaterials.
Numerous
related
studies
combining
photothermal
with
enhanced
were
reviewed.
Finally,
perspective
future
development
tissue
engineering
discussed.
This
will
provide
useful
reference
tumor-related
disease
field
complex
diseases
combine
engineering.
Polymers,
Journal Year:
2021,
Volume and Issue:
13(4), P. 650 - 650
Published: Feb. 22, 2021
The
transfer
of
some
innovative
technologies
from
the
laboratory
to
industrial
scale
is
many
times
not
taken
into
account
in
design
and
development
functional
materials
such
as
hydrogels
be
applied
biomedical
field.
There
a
lack
knowledge
scientific
field
where
aspects
scaling
an
process
are
ignored,
products
cannot
reach
market.
Injectable
good
example
that
we
have
used
our
research
show
different
steps
needed
follow
get
product
market
based
on
them.
From
synthesis
validation
characterization
techniques
assays
performed
ensure
safety
efficacy
product,
following
regulation,
several
well-defined
protocols
must
adopted.
Therefore,
this
paper
summarized
all
these
due
exists
about
industrialization
injectable
with
great
importance
it
entails,
intended
serve
guide
area
non-initiated
scientists.
More
concretely,
work,
characteristics
requirements
for
presented
terms
(i)
employed
obtain
tunable
desired
properties,
(ii)
most
common
characterize
hydrogels,
(iii)
necessary
industrialize
commercialize
regulatory
point
view.
Finally,
review
also
mentioned
explained
real
natural
hyaluronic
acid
hydrogel
reached
product.
Macromolecular Rapid Communications,
Journal Year:
2021,
Volume and Issue:
42(10)
Published: April 20, 2021
Abstract
Injectable
hydrogel
possesses
great
application
potential
in
disease
treatment
and
tissue
engineering,
but
damage
to
gel
often
occurs
due
the
squeezing
pressure
from
injection
devices
mechanical
forces
limb
movement,
leads
rapid
degradation
of
matrix
leakage
load
material.
The
self‐healing
injectable
hydrogels
can
overcome
these
drawbacks
via
automatically
repairing
structural
defects
restoring
function.
polysaccharide
constructed
through
Schiff
base
reaction
own
advantages
including
simple
fabrication,
injectability,
under
physiological
conditions,
therefore
have
drawn
extensive
attention
investigation
recently.
In
this
short
review,
preparation
properties
that
is
established
on
are
focused
their
biological
applications
drug
delivery
cell
therapy
discussed.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.