Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 273 - 273
Published: Jan. 24, 2022
Diabetes
mellitus
is
a
chronic
disease
with
high
mortality
rate
and
many
complications.
A
non-healing
diabetic
foot
ulcer
(DFU)
one
the
most
serious
complications,
leading
to
lower-extremity
amputation
in
15%
of
patients.
Nanofibers
are
emerging
as
versatile
wound
dressing
due
their
unique
healing
properties,
such
surface
area
volume
ratio,
porosity,
ability
maintain
moist
environment
capable
delivering
sustained
drug
release
oxygen
supply
wound.
The
present
study
was
aimed
prepare
evaluate
polyvinyl
alcohol
(PVA)-sodium
alginate
(SA)-silk
fibroin
(SF)-based
multifunctional
nanofibrous
scaffold
loaded
asiaticoside
(AT)
rats.
SEM
findings
showed
that
fibers'
diameters
ranged
from
100-200
nm,
tensile
strengths
12.41-16.80
MPa.
crosslinked
nanofibers
were
AT
over
an
extended
period.
MTT
scratch
assay
on
HaCat
cells
confirmed
low
cytotoxicity
significant
cell
migration,
respectively.
Antimicrobial
tests
revealed
excellent
anti-microbial
efficacy
against
P.
aeruginosa
S.
aureus
bacteria.
In-vivo
demonstrated
better
In
addition,
histopathological
studies
its
restore
normal
structure
skin.
concluded
developed
have
great
potential
for
applications.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(12), P. 20600 - 20606
Published: Dec. 6, 2021
Particle-based
drug
delivery
systems
have
a
demonstrated
value
in
osteoarthritis
treatment.
Research
this
area
trends
to
developing
functional
particles
improve
the
therapeutic
effects.
Herein,
inspired
by
super
lubricated
surface
of
ice
that
consists
contiguous
and
ultrathin
layer
bound
water,
we
developed
2-methylacryloyloxyethyl
phosphorylcholine
(MPC)
decorated
methacrylate
anhydride-
hyaluronic
acid
(HAMA)
particle
with
satisfying
strength
enhanced
lubrication
from
microfluidic
electrospray
for
Benefiting
precise
control
flows,
generated
are
imparted
well-tailored
sizes
good
dispersion.
As
HAMA
were
modified
MPC
positively
(N+(CH3)3)
negatively
(PO4–)
charged
chemical
groups,
they
effect
reduced
friction
on
joint
interface
forming
hydrated
lubricating
layer.
We
MPC-modified
could
be
employed
as
microcarriers
loading
diclofenac
sodium
(DS)
inhibit
inflammatory
response,
thus
further
enhancing
vivo
vitro.
Thus,
proposed
satisfactory
biocompatibility
great
potential
clinical
applications.
Advanced Engineering Materials,
Journal Year:
2022,
Volume and Issue:
24(6)
Published: April 5, 2022
Since
ancient
times,
wound
dressings
have
experienced
many
significant
improvements.
Evolution
began
using
natural
materials
to
merely
cover
wounds
and
advanced
used
innovative
techniques
that
can
be
customized
perform
different
impressive
functions.
Recent
dressings,
which
are
made
of
electrospun
polymers,
contain
active
compounds,
such
as
antimicrobial
agents,
aid
in
healing
prevent
dehydration
infection.
The
mentioned
issues
may
influence
the
process,
leading
even
serious
health
risks
for
patients.
As
a
result,
scientists
now
working
on
novel
bandages
with
improved
properties.
Electrospun
polymeric
nanofibers,
because
their
structural
similarities
normal
skin's
extracellular
matrix
(ECM),
bactericidal
activity,
appropriateness
distribute
bioactive
molecules
location,
regarded
good
resources
enhancing
skin
regeneration
controlling
Herein,
latest
findings
approaches
producing
nanofibers
electrospinning
related
processes
discussed.
advances
antibacterial
biopolymeric
incorporating
nanoparticles
(silver,
zinc
oxide,
copper
etc.)
This
review
paper
raise
issues,
encourage
additional
research,
offer
important
insight
into
potential
area
fibers.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(5), P. 3359 - 3378
Published: Jan. 1, 2024
Electrostatic
spinning
as
a
technique
for
producing
nanoscale
fibers
has
recently
attracted
increasing
attention
due
to
its
simplicity,
versatility,
and
loadability.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(12)
Published: Jan. 31, 2024
Abstract
The
skin
serves
as
the
body's
outermost
barrier
and
is
largest
organ,
providing
protection
not
only
to
body
but
also
various
internal
organs.
Owing
continuous
exposure
external
factors,
it
susceptible
damage
that
can
range
from
simple
severe,
including
serious
types
of
wounds
such
burns
or
chronic
wounds.
Macrophages
play
a
crucial
role
in
entire
wound‐healing
process
contribute
significantly
regeneration.
Initially,
M1
macrophages
infiltrate
phagocytose
bacteria,
debris,
dead
cells
fresh
As
tissue
repair
activated,
M2
are
promoted,
reducing
inflammation
facilitating
restoration
dermis
epidermis
regenerate
tissue.
This
suggests
extracellular
matrix
(ECM)
promotes
cell
adhesion,
proliferation,
migrationand
macrophage
polarization.
Among
numerous
strategies,
electrospinning
versatile
technique
for
obtaining
ECM‐mimicking
structures
with
anisotropic
isotropic
topologies
micro/nanofibers.
Various
electrospun
biomaterials
influence
polarization
based
on
their
topologies.
Moreover,
these
fibers
possess
high
surface‐area‐to‐volume
ratio,
promoting
effective
exchange
vital
nutrients
oxygen,
which
viability
Micro/nanofibers
diverse
physical
chemical
properties
be
tailored
polarize
toward
regeneration
wound
healing,
depending
specific
requirements.
review
describes
significance
micro/nanostructures
activating
healing.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 25, 2024
Silk
fibroin
is
an
important
natural
fibrous
protein
with
excellent
prospects
for
tissue
engineering
applications.
With
profound
studies
in
recent
years,
its
potential
repair
has
been
developed.
A
growing
body
of
literature
investigated
various
fabricating
methods
silk
and
their
application
repair.
The
purpose
this
paper
to
trace
the
latest
developments
SF-based
scaffolds
engineering.
In
review,
we
first
presented
primary
secondary
structures
fibroin.
processing
SF
were
then
summarized.
Lastly,
examined
contribution
new
applying
as
regeneration
Overall,
review
showed
progress
fabrication
utilization
fibroin-based
scaffolds.
