Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(5), P. 1027 - 1057

Published: June 30, 2022

Language: Английский

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Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(19), P. 5369 - 5390

Published: Jan. 1, 2022

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials.

Language: Английский

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Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Macromolecular Materials and Engineering, Journal Year: 2023, Volume and Issue: 309(4)

Published: Nov. 23, 2023

Abstract In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by novel spinneret, is homemade conducting processes. The types electrospun nanofibers E1, electrosprayed microparticles E2, core‐shell E3. SEM TEM results indicate that they have anticipated morphologies inner structures. X‐ray diffraction Fourier Transform Infrared verify KET mainly amorphous in all composites due its fine compatibility with HPMC. vitro tests demonstrate rapid release performances has an order E3>E1>E2≫KET powders. mechanisms suggested advantages compared. super performance E3 furnishing attributed synergistic action small size (of shell thickness), high porosity, state drug, solubility nanostructures can support development nano delivery systems (DDSs) through tailoring spatial distribution molecules within products.

Language: Английский

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Eco-friendly Electrospinning of Recycled Nylon 6,12 Waste for High-Performance Nonwoven Nanofibers in Sustainable Textile Applications

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(4), P. 1491 - 1505

Published: Jan. 22, 2024

Language: Английский

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Photo-responsive electrospun polymer nanofibers: Mechanisms, properties, and applications

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101312 - 101312

Published: May 18, 2024

Language: Английский

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Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 31, 2024

Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.

Language: Английский

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Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435

Published: Feb. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Language: Английский

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Electrospinning Technology, Machine Learning, and Control Approaches: A Review

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Electrospinning is a versatile technique for producing micro‐ and nanoscale fibers, offering vast potential to address critical market demands, particularly in biomedical engineering. However, the industrial adoption of electrospinning as manufacturing technology faces significant hurdles, notably achieving precise control over fiber properties ensuring reproducibility scalability. These challenges directly impact its viability creating advanced products. Bridging gap between material properties, end‐user requirements, process parameters essential unlocking full electrospinning. This work provides comprehensive review modalities, operational factors, modeling techniques, emphasizing their role optimizing process. The use strategies machine learning methods explored, showcasing enhance performance. highlights connection product performance electrospinning, well necessary conditions applications. In addition, identifies gaps unexplored areas, roadmap future innovation fabrication. By synergy intelligent design applications, this lays groundwork advancements, positioning cornerstone next‐generation technologies.

Language: Английский

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Biopolymer-based electrospun fibers in electrochemical devices: versatile platform for energy, environment, and health monitoring

Materials Horizons, Journal Year: 2022, Volume and Issue: 9(12), P. 2914 - 2948

Published: Jan. 1, 2022

Electrochemical power tools, fabricated using the natural-based electrospun fibers, are regarded as essential keys in a world that is becoming increasingly reliant on fossil fuels order to meet challenges of rapidly depleting fuel supplies.

Language: Английский

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Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 10(1)

Published: Nov. 14, 2022

Abstract This review addresses the latest advancements in integration of aggregation‐induced emission (AIE) materials with polymer electrospinning, to accomplish fine‐scale electrospun fibers tunable photophysical and photochemical properties. Micro‐ nanoscale augmented AIE dyes (termed AIEgens) are bespoke composite systems that can overcome limitation posed by aggregation‐caused quenching, a critical deficiency conventional luminescent materials. comprises three parts. First, reader is exposed basic concepts fundamental mechanisms underpinning restriction intermolecular motions. followed an introduction electrospinning techniques pertinent AIE‐based fibers, core parameters for controlling fiber architecture resultant Second, exemplars drawn from research demonstrate how nanofibers porous films incorporating modified AIEgens (especially tetraphenylethylene triphenylamine derivatives) yield enhanced photostability, photothermal properties, photoefficiency (quantum yield), improved device sensitivity. Advanced applications several promising sectors, encompassing optoelectronics, drug delivery biology, chemosensors mechanochromic sensors, innovative devices, among others. Finally, outstanding challenges together potential opportunities nascent field AIE‐active presented, stimulating frontier explorations this exciting field.

Language: Английский

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