Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization DOI

Hyeonseo Park,

Tejal V. Patil, Sayan Deb Dutta

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 31, 2024

Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.

Language: Английский

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing DOI Open Access
Yutong Yang, Meng Li,

Guoying Pan

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)

Published: April 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Language: Английский

Citations

143
Applications of electrospinning in human health: From detection, protection, regulation to reconstruction DOI
Yifan Si, Shuo Shi, Jinlian Hu

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 48, P. 101723 - 101723

Published: Dec. 13, 2022

Language: Английский

Citations

110
Advances in chitosan-based wound dressings: Modifications, fabrications, applications and prospects DOI

Maocheng Ji,

Jianyong Li, Yi Wang

et al.

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 297, P. 120058 - 120058

Published: Aug. 31, 2022

Language: Английский

Citations

77
Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing DOI Creative Commons

Ziwei Jiang,

Zijun Zheng,

Shengxiang Yu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829

Published: June 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Language: Английский

Citations

72
Electrospun trilayer eccentric Janus nanofibers for a combined treatment of periodontitis DOI
Ping Zhao,

Kecong Zhou,

Yiru Xia

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(4), P. 1053 - 1073

Published: April 12, 2024

Language: Английский

Citations

72
Advances in wound dressing based on electrospinning nanofibers DOI Open Access
Xiaotong Zhang, Yanxin Wang, Zhiyuan Gao

et al.

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 141(1)

Published: Oct. 3, 2023

Abstract In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity permeability air water, effective barrier properties against external pathogens, excellent resemblance the extracellular matrix wound healing skin regeneration. This article reviews advancements in application of electrospinning healing. The review begins with an overview process methods. It then explores advantages disadvantages different synthetic natural polymers used preparation dressings. discussed this include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, sodium alginate. Additionally, delves into commonly like polyvinyl alcohol, chloride, polyethylene lactone, polylactide, polyurethane applications. Furthermore, examines blending create high‐performance also incorporation functional additives, such as antimicrobial agents, growth factors, extracts, expedite tissue repair. conclusion, is emerging technology that provides unique opportunities designing more care products.

Language: Английский

Citations

66
Establishments and Evaluations of Post‐Operative Adhesion Animal Models DOI
Yi Wang, Weijie Zhai, Lan Yang

et al.

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(4)

Published: Feb. 4, 2023

Abstract After abdominopelvic surgery, there are 90–93% of patients who develop postoperative adhesions. Post‐operative adhesions can occur after various surgical procedures, which not only cause a series complications but also increase the economic burden patients. Based on US FDA rules, anti‐adhesive products need to be deeply evaluated for their bio‐functionality in animal models before clinic entrance. However, date, few literatures systematically summarizing establish approaches and evaluation standards post‐operative adhesion models. Therefore, according importance knowledge related vivo models, this manuscript, occurrence mechanism is reviewed, followed by construction methods at different organs, then common indicators including scores histological characterization listed. This review reference characterizations materials.

Language: Английский

Citations

55
Emerging Bioprinting for Wound Healing DOI
Zijian Wang, Xiao Liang, Guanyi Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Language: Английский

Citations

54
Double-network cellulose-based hybrid hydrogels with favourable biocompatibility and antibacterial activity for wound healing DOI
Weikang Hu, Zesheng Chen, Xi Chen

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 319, P. 121193 - 121193

Published: July 11, 2023

Language: Английский

Citations

52
Supramolecular hydrogels for wound repair and hemostasis DOI

Shaowen Zhuo,

Yongping Liang,

Zhengying Wu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

Citations

51