An Injectable IPN Nanocomposite Hydrogel Embedding Nano Silica for Tissue Engineering Application DOI Creative Commons

Ali Kakapour,

Saied Nouri Khorasani, Shahla Khalili

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 310(1)

Published: Oct. 24, 2024

Abstract Gelatin methacrylate (GM) and sodium alginate (SA) are two biomaterials that have been widely employed in tissue engineering, particularly 3D bioprinting. However, they some drawbacks including undesirable physico‐mechanical properties printability, hindering their application. This work developed an interpenetrating polymeric network (IPN) of GM SA reinforced with silica nanoparticles (SNPs) to deal hydrogels’ drawbacks. Besides, for cross‐linking, visible light is used as alternative UV prevent disruptions cellular metabolism immune system reactions. Four GM/SA/SNP hydrogels different SNPs concentration (0, 0.5, 1, 2 w/w%) studied. The performance the evaluated terms (viscoelasticity, compressive modulus, degradation, swelling), rheological properties, biological (fibroblast cell growth adhesion, MTT assay). results demonstrated hydrogel 1% provided desirable physical (645% swelling 59.3% degradation), mechanical strength (270 kPa), (tan δ almost 0.14), performances (≈98% viability after 3 days) while maintaining appropriate printability. findings suggest holds great potential applications soft regeneration.

Language: Английский

Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties DOI
Fariba Mehvari, Vahid Ramezanzade, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093

Published: July 25, 2024

Language: Английский

Citations

12
An injectable, self-healable, and antimicrobial hydroxypropyl chitosan/poly(vinyl alcohol) hydrogel for drug delivery systems DOI
Jingping Qiu,

Jue Lan,

Yilei Xiang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 698, P. 134587 - 134587

Published: Oct. 1, 2024

Language: Английский

Citations

8
Covalent Organic Framework (COF)—Topical Game Changer for Polymeric Nanocomposites DOI
Ayesha Kausar

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32

Published: April 10, 2025

Language: Английский

Citations

0
Effect of zein nanoparticles addition on anthocyanin and lutein dual-loaded nanocomposite hydrogels: Structure, physico-chemical and delivery properties DOI
Shuaizhen Fang, Yingjie Wang, Lin Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142967 - 142967

Published: April 1, 2025

Language: Английский

Citations

0
IPN nanocomposite scaffolds based on GelMA-alginate with modified super-paramagnetic iron oxide for cartilage tissue engineering DOI

Mahdieh Abtahi,

Saied Nouri Khorasani, Shahla Khalili

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143845 - 143845

Published: May 1, 2025

Language: Английский

Citations

0
Nanomaterial-integrated injectable hydrogels for craniofacial bone reconstruction DOI Creative Commons
Yong Xia, Zihan Chen,

Zebin Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 31, 2024

The complex anatomy and biology of craniofacial bones pose difficulties in their effective precise reconstruction. Injectable hydrogels (IHs) with water-swollen networks are emerging as a shape-adaptive alternative for noninvasively rebuilding bones. advent versatile nanomaterials (NMs) customizes IHs strengthened mechanical properties therapeutically favorable performance, presenting excellent contenders over traditional substitutes. Structurally, NM-reinforced energy dissipative covalently crosslinked, providing the mechanics necessary to support structures physiological functions. Biofunctionally, incorporating unique NMs into IH expands plethora biological activities, including immunomodulatory, osteogenic, angiogenic, antibacterial effects, further favoring controllable dynamic tissue regeneration. Mechanistically, NM-engineered optimize physical traits direct cell responses, regulate intracellular signaling pathways, control release biomolecules, collectively bestowing structure-induced features multifunctionality. By encompassing state-of-the-art advances NM-integrated IHs, this review offers foundation future clinical translation bone

Language: Английский

Citations

1
An Injectable IPN Nanocomposite Hydrogel Embedding Nano Silica for Tissue Engineering Application DOI Creative Commons

Ali Kakapour,

Saied Nouri Khorasani, Shahla Khalili

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 310(1)

Published: Oct. 24, 2024

Abstract Gelatin methacrylate (GM) and sodium alginate (SA) are two biomaterials that have been widely employed in tissue engineering, particularly 3D bioprinting. However, they some drawbacks including undesirable physico‐mechanical properties printability, hindering their application. This work developed an interpenetrating polymeric network (IPN) of GM SA reinforced with silica nanoparticles (SNPs) to deal hydrogels’ drawbacks. Besides, for cross‐linking, visible light is used as alternative UV prevent disruptions cellular metabolism immune system reactions. Four GM/SA/SNP hydrogels different SNPs concentration (0, 0.5, 1, 2 w/w%) studied. The performance the evaluated terms (viscoelasticity, compressive modulus, degradation, swelling), rheological properties, biological (fibroblast cell growth adhesion, MTT assay). results demonstrated hydrogel 1% provided desirable physical (645% swelling 59.3% degradation), mechanical strength (270 kPa), (tan δ almost 0.14), performances (≈98% viability after 3 days) while maintaining appropriate printability. findings suggest holds great potential applications soft regeneration.

Language: Английский

Citations

1