Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis
ACS Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
10(7), P. 2356 - 2380
Published: June 7, 2024
Fungal
keratitis
(FK)
is
a
severe
ocular
condition
resulting
from
corneal
infection
that
prevalent
in
tropical
countries,
particularly
developing
regions
of
Asia
and
Africa.
Factors
like
lens
misuse,
inappropriate
steroid
use,
diagnostic
challenges
have
provoked
the
epidemic.
FK
causes
significant
vision
impairment,
scarring,
deformities.
Accurate
pathological
diagnosis
crucial
for
effective
therapeutic
intervention.
Topical
antifungal
therapy
with
surface
healing
medications
proves
preventing
fungal-borne
ulcers.
Managing
requires
comprehensive
understanding
fungal
pathogenesis,
guiding
formulation
strategies
preventive
measures
to
curb
global
blindness.
This
review
provides
in-depth
insights
into
FK,
covering
etiology,
epidemiology,
interventions,
resistance,
limitations,
prevention,
future
perspectives
on
disease
management.
Language: Английский
Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer
Danrong Hu,
No information about this author
Yicong Li,
No information about this author
Ran Li
No information about this author
et al.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Language: Английский
Recent updates on ocular disease management with ophthalmic ointments
Therapeutic Delivery,
Journal Year:
2024,
Volume and Issue:
15(6), P. 463 - 480
Published: June 2, 2024
Ophthalmic
diseases
can
result
in
permanent
vision
loss
and
blindness.
Convenient
topical
systemic
treatments
are
preferred
to
address
these
sight-threatening
conditions.
However,
the
unique
anatomy
of
eye
presents
challenges
for
drug
delivery.
Various
ophthalmic
ointment
formulations
have
been
developed
enhance
bioavailability
prolong
residence
time
improve
corneal
permeability.
This
article
explores
a
wide
range
ocular
affecting
individuals
globally
how
ointments
used
manage
them.
From
barriers,
this
review
focuses
on
published
scientific
research
formulation
strategies
severe
complications
using
conventional
ointments.
Additionally,
it
delves
through
patented
technologies
marketed
supporting
use
Language: Английский
Low-density polyamide 12 foams using bayesian optimization and inverse design
Karim Ali Shah,
No information about this author
Rodrigo Q. Albuquerque,
No information about this author
Christian Brütting
No information about this author
et al.
Polymer,
Journal Year:
2025,
Volume and Issue:
unknown, P. 128096 - 128096
Published: Feb. 1, 2025
Language: Английский
Feeling of an Eye When It Meets the Unseen “Nano”
Salman Khan,
No information about this author
Sneha Asok,
No information about this author
Veda V. Dasari
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Nanomedicine
is
increasingly
being
utilized
in
addressing
various
eye
ailments
and
holds
immense
potential
rectifying
ocular
diseases;
however,
the
interactions
between
nanomedicines
their
route
of
administration
via
tear
fluid
remain
poorly
understood.
When
nanoparticles
are
introduced
into
fluid,
a
layer
protein
corona
formed
on
surface
that
not
only
influences
properties
biological
fate
but
also
potentially
interferes
with
function
endogenous
proteins.
To
investigate
gold
nanoaprticles
(AuNPs)
focusing
physicochemical
changes
particles,
to
quantitatively
qualitatively
identify
key
proteins
involved
formation,
we
employed
label-free
techniques
for
material
biophysical
characterizations
along
proteomic
analyses
mass
spectrometry.
The
AuNPs
remained
stable
without
forming
aggregates,
showing
an
∼31
nm
increase
hydrodynamic
diameter
after
interacting
fluid.
Notably,
overall
zeta
increased
significantly
from
-12
-23
eV
due
supplemented
charge
by
adsorbed
Proteomic
analysis
liquid
chromatography/mass
spectrometry
(LC-MS/MS)
identified
31
were
bound
total
174
detected
Bioinformatic
classification
revealed
enrichment
specific
essential
health;
such
as
clusterin,
lactotransferrin,
adenosine
triphosphate
(ATP)
synthase,
lysozyme,
alpha
enolase,
keratin,
apolipoprotein,
epidermal
growth
factor
receptor
(EGFR)
pivotal
roles
anti-inflammatory,
immune
response,
cell
adhesion,
cellular
organization,
plasminogen
activation,
signaling,
stress
corneal
epithelial
homeostasis.
Overall,
our
study
provides
unresolved
comprehensive
map
landscape
its
impact
nanoparticle
behavior
These
insights
must
be
considered
valuable
designing
safer
more
effective
treatment
diseases.
Language: Английский
Functional Nanoparticle Developments for 3D-Printed Biodegradable Implants- A Comprehensive Review
Results in Surfaces and Interfaces,
Journal Year:
2025,
Volume and Issue:
19, P. 100541 - 100541
Published: May 1, 2025
Language: Английский
An Overview of Novel Formulations For Ocular Viral Infections: Focused On Nanomedicines
Shalu Verma,
No information about this author
Nidhi Nainwal,
No information about this author
Divya Juyal
No information about this author
et al.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 45
Published: June 6, 2025
Ocular
viral
infections
are
a
common
cause
of
blindness
globally.
Many
ocular
mistakenly
identified
as
bacterial
infections.
In
these
situations,
treatment
is
initiated
belatedly
and
fails
to
address
the
root
infection,
which
frequently
results
in
serious
complications
like
corneal
infiltrates,
conjunctival
scarring,
decreased
visual
acuity.
The
efficacy
conventional
treatments
for
suffers
from
poor
bioavailability,
requires
development
novel
methods
drug
delivery,
accurate
diagnosis,
efficient
choices.
As
nanotechnology
medicine
advances
at
rapid
pace,
multifunctional
nanosystems
being
prioritized
more
problems
brought
on
by
eyes
offering
targeted
increased
bioavailability
systemic
toxicity.
This
study
delivers
thorough
overview
use
nanomedicines
infections,
with
particular
emphasis
how
they
may
enhance
safety
antiviral
drugs.
We
range
nanocarrier
systems,
such
liposomes,
nanoparticles,
nanosuspension,
proniosomes,
in-situ
gels,
dendrimers,
nanogels,
emphasizing
their
distinct
characteristics
that
facilitate
effective
transportation
drugs
tissues.
article
also
highlighted
regulatory
barriers
nanoformulation.
transition
in-vitro
studies
in-vivo
clinical
models
has
been
discussed.
review
highlights
Preclinical
treatment,
nanotoxicology
advancement
form
patents,
ongoing
trials
marketed
formulations.
Language: Английский
Poly(allylamine)-adorned heptylcarboxymethyl galactomannan nanocarriers of canagliflozin for controlling type-II diabetes: Optimization by Box-Behnken design and in vivo performance
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
277, P. 134253 - 134253
Published: July 30, 2024
Language: Английский