Harmony Within: Unravelling the Microbiome–Immune System Symbiosis for Health DOI Creative Commons
Anuupama Suchiita, Neelu Gupta, Kajal Nandi

et al.

Advanced Gut & Microbiome Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The microbiome, a diverse ecosystem of microorganisms within the human body, interacts intricately with immune system to maintain health and prevent disease. This dynamic partnership influences development, inflammation regulation, metabolic health, neurological well‐being, while disruptions, termed dysbiosis, have been linked autoimmune disorders, chronic diseases, mental issues. review highlights microbiome’s role in educating system, modulating responses, supporting physical barriers, addressing key research advances, such as microbial metabolites regulation impact on cancer immunotherapy. Emerging technologies like multiomics machine learning propelled microbiome research, unlocking potential for personalized medicine microbiome‐targeted therapies. Despite progress, challenges remain understanding diversity, individual variability, causation–correlation microbiome–immune interactions. Future directions include precision medicine, engineering, public interventions, interdisciplinary collaborations, positioning symbiosis transformative frontier healthcare innovation.

Language: Английский

Impact of antibiotics on the human microbiome and consequences for host health DOI Creative Commons
Dhrati Patangia,

Cornelius Anthony Ryan,

Eugene Dempsey

et al.

MicrobiologyOpen, Journal Year: 2022, Volume and Issue: 11(1)

Published: Jan. 13, 2022

It is well established that the gut microbiota plays an important role in host health and perturbed by several factors including antibiotics. Antibiotic-induced changes microbial composition can have a negative impact on reduced diversity, functional attributes of microbiota, formation, selection antibiotic-resistant strains making hosts more susceptible to infection with pathogens such as Clostridioides difficile. Antibiotic resistance global crisis increased use antibiotics over time warrants investigation into its effects health. In this review, we discuss adverse thus health, suggest alternative approaches antibiotic use.

Language: Английский

Citations

470
Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised controlled trials DOI
Eric A. F. Simões, Shabir A. Madhi, William J. Muller

et al.

The Lancet Child & Adolescent Health, Journal Year: 2023, Volume and Issue: 7(3), P. 180 - 189

Published: Jan. 9, 2023

Language: Английский

Citations

176
A hybrid nanocomposite based on CuFe layered double hydroxide coated graphene oxide for photocatalytic degradation of trimethoprim DOI
Yasser Vasseghian, Deniz Sezgin, Nguyễn Đình Chiến

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 322, P. 138243 - 138243

Published: Feb. 23, 2023

Language: Английский

Citations

143
Metal–Organic Framework-Based Materials for Wastewater Treatment: Superior Adsorbent Materials for the Removal of Hazardous Pollutants DOI Creative Commons
Harjot Kaur, Nishu Devi, Samarjeet Singh Siwal

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(10), P. 9004 - 9030

Published: Feb. 28, 2023

In previous years, different pollutants, for example, organic dyes, antibiotics, heavy metals, pharmaceuticals, and agricultural have been of note to the water enterprise due their insufficient reduction during standard wastewater processing methods. MOFs found potential toward management. This Review focused on synthesis process (such as traditional, electrochemical, microwave, sonochemical, mechanochemical, continuous-flow spray-drying method) MOF materials. Moreover, properties materials discussed in detail. Further, materials' applications treatment removal metal ions, waste) discussed. Additionally, we compared performances some typical MOFs-based with those other commonly used Finally, study's current challenges, future prospects, outlook highlighted.

Language: Английский

Citations

109
Antibiotic failure: Beyond antimicrobial resistance DOI Creative Commons
César de la Fuente‐Núñez, Angela Cesaro, Robert E. W. Hancock

et al.

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101012 - 101012

Published: Oct. 18, 2023

Language: Английский

Citations

105
Metallic Nanosystems in the Development of Antimicrobial Strategies with High Antimicrobial Activity and High Biocompatibility DOI Open Access

Karol Skłodowski,

Sylwia Joanna Chmielewska-Deptuła,

Ewelina Piktel

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2104 - 2104

Published: Jan. 20, 2023

Antimicrobial resistance is a major and growing global problem new approaches to combat infections caused by antibiotic resistant bacterial strains are needed. In recent years, increasing attention has been paid nanomedicine, which great potential in the development of controlled systems for delivering drugs specific sites targeting cells, such as pathogenic microbes. There continued interest metallic nanoparticles nanosystems based on containing antimicrobial agents attached their surface (core shell nanosystems), offer unique properties, ability overcome microbial resistance, enhancing activity against both planktonic biofilm embedded microorganisms, reducing cell toxicity possibility dosage antimicrobials. The current review presents synergistic interactions within functionalizing with appropriate agents, defining core structure use combination therapy fight infections. Various modulate biocompatibility control future medical applications also discussed, well induce effects host microbiome.

Language: Английский

Citations

80
Current understanding of antibiotic-associated dysbiosis and approaches for its management DOI Creative Commons
Dhanasekhar Kesavelu,

Pramod Jog

Therapeutic Advances in Infectious Disease, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Increased exposure to antibiotics during early childhood increases the risk of antibiotic-associated dysbiosis, which is associated with reduced diversity gut microbial species and abundance certain taxa, disruption host immunity, emergence antibiotic-resistant microbes. The microbiota immunity in life linked development immune-related metabolic disorders later life. Antibiotic administration populations predisposed such as newborns, obese children, children allergic rhinitis recurrent infections; changes composition diversity; exacerbating dysbiosis resulting negative health outcomes. Antibiotic-associated diarrhea (AAD), Clostridiodes difficile-associated (CDAD), Helicobacter pylori infection are all short-term consequences antibiotic treatment that persist from a few weeks months. Changes microbiota, even 2 years after exposure, obesity, allergies, asthma among long-term consequences. Probiotic bacteria dietary supplements can potentially prevent or reverse dysbiosis. Probiotics have been demonstrated clinical studies help AAD and, lesser extent, CDAD, well improve H eradication rates. In Indian setting, probiotics ( Saccharomyces boulardii Bacillus clausii) shown reduce duration frequency acute children. Antibiotics may exaggerate vulnerable already affected by condition. Therefore, prudent use neonates young critical detrimental effects on health.

Language: Английский

Citations

65
Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases DOI Creative Commons

Oana-Alina Petrariu,

Ilda Czobor Barbu, Adelina-Gabriela Niculescu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.

Language: Английский

Citations

58
The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease DOI Creative Commons

Kallie E. Hays,

Jacob M. Pfaffinger,

Rebecca Ryznar

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 16, 2024

Short-chain fatty acids (SCFAs) - acetate, propionate, and butyrate are important bacterial fermentation metabolites regulating many aspects of human physiology. Decreases in the concentrations any or multiple SCFAs associated with various detrimental effects to host. Previous research has broadly focused on gut microbiome produced as a group, minimal distinction between independently, each significantly different host effects. In this review, we comprehensively delineate roles these emphasis receptor affinity, signaling pathway involvement, net physiologic Butyrate is highlighted due its unique role gastrointestinal-associated functions, especially maintaining barrier integrity. functions by promoting epithelial tight junctions, serving fuel for colonocyte ATP production, modulating immune system. Interaction system occurs locally gastrointestinal tract systemically brain. Investigation into conducted production pathways specific players involved highlights risk use gram-positive targeted antibiotics. We review discuss evidence showing relationship butyrate-producing genus,

Language: Английский

Citations

46
Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action DOI Creative Commons
Massimo Sartelli, Philip S. Barie, Federico Coccolini

et al.

World Journal of Emergency Surgery, Journal Year: 2023, Volume and Issue: 18(1)

Published: Oct. 16, 2023

Abstract Antibiotics are recognized widely for their benefits when used appropriately. However, they often inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component universal healthcare, and it a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive develop new antibiotics due scientific, regulatory, financial barriers, further emphasizing To address this issue, Global Alliance Infections in Surgery established international multidisciplinary task force 295 experts from 115 countries with different backgrounds. The developed position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness antimicrobial resistance improving prescribing practices worldwide. outlined 10 axioms, or “golden rules,” that all healthcare workers should consistently adhere

Language: Английский

Citations

45