Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 18, 2025
Abstract
Repair
and
reconstruction
of
critical‐sized
bone
defects
present
a
significant
challenge
due
to
poor
clinical
outcomes
conventional
repair
strategies,
such
as
autologous
allogenic
grafts.
The
study
underscores
the
potential
human
dental
pulp
stem
cell‐derived
trophic
factors
promote
regeneration,
thus
evading
risks
associated
with
cell‐based
therapy.
This
utilizes
pre‐osteoblast
cells
evaluate
osteogenic
2
Dimensional
(2D)
3
(3D)
secretome
from
monolayer
spheroid
cultures
(DPSCs),
respectively.
In‐vitro
results
on
(MC3T3‐EI)
treated
2D
3D
reveal
lower
mineralization
mRNA
expression
specific
genes
in
comparison
secretome.
Furthermore,
shows
better
regeneration
ability
rat
models
calvarial
defect
compared
proteomic
profiles
secretomes
are
also
concordance
these
key
molecules
governing
potential.
data
highlights
influence
culture
conditions
secretory
pattern
mesenchymal
provides
valuable
insights
for
development
more
effective
secretome‐based
cell‐free
alternative
novel
regeneration.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: June 17, 2023
Abstract
Regeneration
is
a
complex
process
affected
by
many
elements
independent
or
combined,
including
inflammation,
proliferation,
and
tissue
remodeling.
Stem
cells
class
of
primitive
with
the
potentiality
differentiation,
regenerate
self‐replication,
multidirectional
immunomodulatory
functions.
their
cytokines
not
only
inextricably
linked
to
regeneration
ectodermal
skin
tissues,
but
also
can
be
used
for
treatment
variety
chronic
wounds.
produce
exosomes
in
paracrine
manner.
cell
play
an
important
role
regeneration,
repair,
accelerated
wound
healing,
biological
properties
which
are
similar
stem
cells,
while
safer
more
effective.
Skin
bone
tissues
critical
organs
body,
essential
sustaining
life
activities.
The
weak
repairing
ability
leads
pronounced
impact
on
quality
patients,
could
alleviated
treatment.
However,
there
obstacles
that
trough
improved
bioavailability.
This
paper
summarizes
applications
mechanisms
healing.
We
propose
new
ways
utilizing
through
different
nanoformulations,
liposomes
nanoliposomes,
polymer
micelles,
microspheres,
hydrogels,
scaffold
microneedles,
improve
use
healing
regeneration.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e35836 - e35836
Published: Aug. 1, 2024
Stem
cell
transplantation
has
emerged
as
a
promising
avenue
in
regenerative
medicine,
potentially
facilitating
tissue
repair
degenerative
diseases
and
injuries.
This
review
comprehensively
examines
recent
developments
challenges
stem
transplantation.
It
explores
the
identification
isolation
of
various
types,
including
embryonic,
induced
pluripotent,
adult
cells
derived
from
multiple
sources.
Additionally,
highlights
tissue-specific
applications
these
cells,
focusing
on
bone
cartilage
regeneration,
treatment
neurological
disorders,
management
hematological
conditions.
Future
advancements
effective
resolution
current
will
be
crucial
fully
realizing
potential
medicine.
With
responsible
ethical
practices,
field
can
transform
disease
injury
treatment,
ultimately
improving
quality
life
for
countless
individuals.
Veterinary Sciences,
Journal Year:
2025,
Volume and Issue:
12(1), P. 67 - 67
Published: Jan. 17, 2025
Stem
cells
are
unique,
undifferentiated
that
have
the
ability
to
both
replicate
themselves
and
develop
into
specialized
cell
types.
This
dual
capability
makes
them
valuable
in
development
of
regenerative
medicine.
Current
stem
research
has
widened
their
application
therapy,
drug
discovery,
reproductive
cloning
animals,
models
for
various
diseases.
Although
there
substantial
studies
revealing
treatment
human
degenerative
diseases
using
cells,
this
is
yet
be
explored
livestock
animals.
Many
species
such
as
mastitis,
laminitis,
neuromuscular
disorders,
autoimmune
diseases,
some
debilitating
not
covered
completely
by
existing
drugs
can
improved
different
types
like
embryonic
adult
induced
pluripotent
cells.
review
mainly
focuses
on
use
disease
In
addition
mentioned,
potential
helpful
wound
healing,
skin
genetic
disorders.
article
explores
from
sources
therapy
also
role
conservation
endangered
well
model
preparation.
Moreover,
future
perspectives
challenges
associated
with
discussed.
Overall,
transformative
impact
sector
comprehensively
studied
which
will
help
researchers
design
work
related
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 7, 2025
To
date,
the
regenerative
potential
of
mitochondrial
transplantation
(MT)
has
been
extensively
investigated
under
several
pathologies.
Among
various
cardiovascular
diseases,
ischemic
heart
disease
(IHD),
most
prevalent
pathological
condition
in
human
medicine,
is
induced
by
coronary
artery
narrowing,
or
occlusion,
leading
to
bulk
necrotic
changes
and
fibrosis
within
myocardium.
Data
associated
with
pro-angiogenic
activity
mitochondria
have
not
completely
elucidated
terms
cardiac
tissue
regeneration.
Here,
we
aimed
highlight
recent
studies
advantages
related
application
mass
How
which
mechanisms,
can
reduce
aberrant
myocardial
remodeling
via
different
pathways
such
as
angiogenesis
de
novo
blood
formation
was
discussed
detail.
We
hope
that
data
from
current
review
article
help
us
understand
molecular
cellular
mechanisms
transplanted
exert
their
properties
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3216 - 3216
Published: March 12, 2024
Hyaluronic
acid
(HA)
is
a
remarkably
multifaceted
biomacromolecule,
playing
role
in
regulating
myriad
biological
processes
such
as
wound
healing,
tissue
regeneration,
anti-inflammation,
and
immunomodulation.
Crosslinked
high-
low-molecular-weight
hyaluronic
hydrogels
achieve
higher
molar
concentrations,
display
slower
degradation,
allow
optimal
product
diffusion,
while
harnessing
the
synergistic
contribution
of
different-molecular-weight
hyaluronans.
A
recent
innovation
world
synthesis
represented
by
NAHYCO®
Hybrid
Technology,
thermal
process
leading
to
hybrid
cooperative
complexes
(HCC).
This
review
summarizes
current
literature
on
vitro
studies
vivo
applications
HCC,
from
facial
body
rejuvenation
future
perspectives
skin
dermatology,
genitourinary
pathologies.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(8), P. 1250 - 1250
Published: Aug. 16, 2023
Mesenchymal
stem
cells
(MSCs)
are
a
type
of
versatile
adult
present
in
various
organs.
These
give
rise
to
extracellular
vesicles
(EVs)
containing
diverse
array
biologically
active
elements,
making
them
promising
approach
for
therapeutics
and
diagnostics.
This
article
examines
the
potential
therapeutic
applications
MSC-derived
EVs
addressing
neurodegenerative
disorders
such
as
Alzheimer’s
disease
(AD),
multiple
sclerosis
(MS),
Parkinson’s
(PD),
amyotrophic
lateral
(ALS),
Huntington’s
(HD).
Furthermore,
state-of-the-art
MSC-EV-based
therapy
AD,
HD,
PD,
ALS,
MS
is
discussed.
Significant
progress
has
been
made
understanding
etiology
treatments
range
diseases
(NDs)
over
last
few
decades.
The
contents
carried
across
intercellular
contact,
which
often
results
control
recipient
cell’s
homeostasis.
Since
represent
therapeutically
beneficial
cargo
parent
devoid
many
ethical
problems
connected
with
cell-based
treatments,
they
offer
viable
cell-free
alternative
tissue
regeneration
repair.
Developing
innovative
EV-dependent
medicines
proven
difficult
due
lack
standardized
procedures
EV
extraction
processes
well
their
pharmacological
characteristics
mechanisms
action.
However,
recent
biotechnology
engineering
research
greatly
enhanced
content
applicability
MSC-EVs.
International Journal of Oral Science,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Dec. 1, 2023
Abstract
Many
tissues
and
organ
systems
have
intrinsic
regeneration
capabilities
that
are
largely
driven
maintained
by
tissue-resident
stem
cell
populations.
In
recent
years,
growing
evidence
has
demonstrated
cellular
metabolic
homeostasis
plays
a
central
role
in
mediating
fate,
tissue
regeneration,
homeostasis.
Thus,
thorough
understanding
of
the
mechanisms
regulate
cells
may
contribute
to
our
knowledge
on
how
is
provide
novel
insights
for
disease
management.
this
review,
we
summarize
known
relationship
between
regulation
molecular
pathways
cells.
We
also
discuss
potential
targets
therapy
describe
current
limitations
future
directions
development
these
therapeutic
targets.
