Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(4)

Published: Nov. 9, 2022

Abstract Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy surgery, exhibit suboptimal efficacy for malignant tumors owing serious side effects, drug resistance even relapse. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), emerging localized tumor inhibition, which can produce a large amount reactive oxygen species (ROS) or elevate temperature initiate cell death by non‐invasive irradiation. In consideration poor bioavailability phototherapy agents (PTAs), lots delivery systems have been developed enhance targeted delivery. Nevertheless, carriers inevitably bring biosafety concerns on account their metabolism, degradation, accumulation. Of note, carrier‐free nanomedicine attracts great attention clinical translation with synergistic antitumor effect, is characterized high loading, simplified synthetic method good biocompatibility. this review, latest advances nanomedicines summarized, may provide new paradigm future development precision therapy.

Language: Английский

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Self-assembly hydrogels of therapeutic agents for local drug delivery

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 898 - 921

Published: Sept. 15, 2022

Language: Английский

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A small-molecule self-assembled nanodrug for combination therapy of photothermal-differentiation-chemotherapy of breast cancer stem cells

Biomaterials, Journal Year: 2022, Volume and Issue: 286, P. 121598 - 121598

Published: May 24, 2022

Language: Английский

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A Comprehensive Review and Analysis of Nanosensors for Structural Health Monitoring in Bridge Maintenance: Innovations, Challenges, and Future Perspectives

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(20), P. 11149 - 11149

Published: Oct. 10, 2023

This paper presents a thorough review and detailed analysis of nanosensors for structural health monitoring (SHM) in the context bridge maintenance. With rapid advancements nanotechnology, have emerged as promising tools detecting assessing integrity bridges. The objective this is to provide comprehensive understanding various types utilized maintenance, their operating principles, fabrication techniques, integration strategies. Furthermore, explores challenges associated with nanosensor deployment, such signal processing, power supply, data interpretation. Finally, concludes an outlook on future developments field SHM

Language: Английский

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Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Aggregate, Journal Year: 2023, Volume and Issue: 5(1)

Published: Oct. 12, 2023

Abstract Nowadays, cancer has become the leading cause of death worldwide, driving need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) been widely applied as an antitumor modality, owing its minimal invasiveness, localized tumor damage, and high safety profile. However, efficacy is limited by poor stability photosensitizers, inadequate accumulation, a complex microenvironment. To overcome these challenges, extensive endeavors have made explore co‐assembly used photosensitizer chlorin e6 (Ce6) with various functional small molecules enhance pharmacodynamic activity. This review provides comprehensive overview current studies on Ce6‐based nanoparticles PDT precise delivery molecules. The self‐assembly mechanism will be discussed in detail, focus potential strategies combinational PDT.

Language: Английский

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Doxorubicin covalently conjugated heparin displays anti-cancer activity as a self-assembled nanoparticle with a low-anticoagulant effect

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 314, P. 120930 - 120930

Published: April 18, 2023

Language: Английский

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Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150

Published: March 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Language: Английский

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Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68

Published: Jan. 6, 2025

Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.

Language: Английский

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Triethylamine-mediated protonation–deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(5)

Published: Jan. 28, 2025

Carrier-free nanomedicines exhibited significant potential in elevating drug efficacy and safety for tumor management, yet their self assembly typically relied on chemical modifications of drugs or the incorporation surfactants, thereby compromising drug’s inherent pharmacological activity. To address this challenge, we proposed a triethylamine (TEA)-mediated protonation–deprotonation strategy that enabled adjustable-proportion dual without modification, achieving nearly 100% loading capacity. Molecular dynamic simulations, supported by experiment evidence, elucidated underlying self-assembly mechanism. Specifically, TEA facilitated deprotonation Doxorubicin (Dox) α-Tocopherol succinate (α-tos), causing Dox to transition from hydrophilic hydrophobic state, while simultaneously increasing hydrophilicity α-tos. This allowed fine-tuned balance between properties two compounds, enabling precise into carrier-free nanomedicine (DT) with tailored ratio. The engineered DT demonstrated ability accumulate at sites release its therapeutic controlled manner. combination α-tos synergistically generated reactive oxygen species modulated expression matrix metalloproteinase-9, leading superior antitumor metastasis, maintaining excellent profiles. Our findings provided unique perspectives design cancer therapy, laying solid foundation clinical translation.

Language: Английский

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Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(8), P. 2291 - 2302

Published: Jan. 23, 2021

Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high efficiency security, nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs developed on basis dual-mode co-loading photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly chlorine e6 (Ce6, donor) 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR, acceptor) for breast treatment. Notably, Ce6 in the nanoassemby quenched DiR could be unlocked photodynamic therapy (PDT) only when photobleached 808-nm laser. As result, Ce6-caused phototoxicity well controlled. Under cascaded laser irradiation (808–660 nm), tumor-localizing temperature rise following not induces tumor cell apoptosis but also facilitates penetration NPs, relieves hypoxia, promotes PDT Ce6. Such pair-based provides new strategy developing multimodal phototherapy nanomedicines with good security.

Language: Английский

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