AI energized hydrogel design, optimization and application in biomedicine

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 101014 - 101014

Published: Feb. 29, 2024

Traditional hydrogel design and optimization methods usually rely on repeated experiments, which is time-consuming expensive, resulting in a slow-moving of advanced development. With the rapid development artificial intelligence (AI) technology increasing material data, AI-energized hydrogels for biomedical applications has emerged as revolutionary breakthrough materials science. This review begins by outlining history AI potential advantages using hydrogels, such prediction properties, multi-attribute optimization, high-throughput screening, automated discovery, optimizing experimental design, etc. Then, we focus various supported biomedicine, including drug delivery, bio-inks manufacturing, tissue repair, biosensors, so to provide clear comprehensive understanding researchers this field. Finally, discuss future directions prospects, new perspective research novel applications.

Language: Английский

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A pH-responsive, injectable and self-healing chitosan-coumarin hydrogel based on Schiff base and hydrogen bonds

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 255, P. 128122 - 128122

Published: Nov. 18, 2023

Language: Английский

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Sustainable Biomass Lignin-Based Hydrogels: A Review on Properties, Formulation, and Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13493 - 13493

Published: Aug. 30, 2023

Different techniques have been developed to overcome the recalcitrant nature of lignocellulosic biomass and extract lignin biopolymer. Lignin has gained considerable interest owing its attractive properties. These properties may be more beneficial when including in preparation highly desired value-added products, hydrogels. biopolymer, as one three major components biomaterials, attracted significant biomedical field due biocompatibility, biodegradability, antioxidant antimicrobial activities. Its valorization by developing new hydrogels increased recent years. Furthermore, lignin-based shown great potential for various applications, their copolymerization with other polymers biopolymers further expands possibilities. In this regard, can synthesized a variety methods, but not limited interpenetrating polymer networks polymerization, crosslinking copolymerization, grafted monomers, atom transfer radical reversible addition–fragmentation polymerization. As an example, mechanism lignin–chitosan–poly(vinyl alcohol) (PVA) hydrogel involves active groups such hydroxyl, carboxyl, sulfonic that form hydrogen bonds (with chemical structures chitosan and/or PVA) ionic PVA). The aim review paper is provide comprehensive overview focusing on applications these addition, we explore wound healing, drug delivery systems, 3D bioprinting, showcasing unique enable successful utilization areas. Finally, discuss future trends draw conclusions based findings presented.

Language: Английский

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Enhancing Chronic Wound Healing through Engineering Mg²⁺-Coordinated Asiatic Acid/Bacterial Cellulose Hybrid Hydrogels

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8238 - 8249

Published: Feb. 12, 2024

Infectious chronic wounds have gradually become a major clinical problem due to their high prevalence and poor treatment outcomes. The urgent need for wound dressings with immune modulatory, antibacterial, angiogenic properties has led the development of innovative solutions. Asiatic acid (AA), derived from herbs, demonstrated excellent anti-inflammatory, effects, making it promising candidate incorporation into hydrogel carriers healing. However, there is currently no available report on AA-based self-assembled hydrogels. Here, novel hybrid dressing consists interpenetrating polymer networks composed magnesium ion (Mg2+) coordinated asiatic (AA-Mg) bacterial cellulose (BC) developed promote infected A natural carrier-free AA-Mg good injectable self-healing could maintain sustained release AA Mg2+ over an extended period. Notably, introduction boosted some pharmacological effects hydrogels its anti-inflammatory angiogenesis. In vitro studies confirmed exceptional biocompatibility, antibacterial efficacy, potential AA-Mg/BC hydrogel, which also exhibited commendable mechanical strength. Furthermore, in vivo biological results displayed that significantly accelerated healing process by boosting dense organized collagen deposition granulation tissue benefiting revascularization. introduced AA-Mg-based offers solution effective management wounds. This universal strategy preparation modulated bioactive divalent metal ions able excavate more herbal small molecules construct new biomaterials.

Language: Английский

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Enzyme‐Immobilized Surface‐Catalyzed Cross‐Linking: Creating Multifunctional Double Network Hydrogel Coatings on Diverse Substrates

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(27)

Published: March 7, 2024

Abstract Hydrogel coatings, with natural tissue‐like mechanical and biological compatibility, demonstrate promise for bulk material applications. However, existing coating methods lack efficiency control, especially when dealing complex geometries, diverse substrate materials, varying sizes. In this study, an enzyme‐immobilized surface‐catalyzed cross‐link approach is proposed the growth of hydrogel coatings on multiple substrates, accommodating various materials shapes. The formed through catalytic action interface‐immobilized enzymes, which induce crosslinking hyaluronic acid, its properties are further enhanced by introducing a secondary polyacrylamide network. This enables controlled conformal double network desired thickness wide range surfaces devices. Notably, exhibits remarkable lubricity anti‐thrombotic properties, desire medical intervention advancement offers universal route to impart biocompatible soft interfaces or

Language: Английский

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Recoverable and degradable carboxymethyl chitosan polyelectrolyte hydrogel film for ultra stable encapsulation of curcumin

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131616 - 131616

Published: April 15, 2024

Language: Английский

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Chitin nanofibrils assisted 3D printing all-chitin hydrogels for wound dressing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122028 - 122028

Published: March 6, 2024

Language: Английский

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Current progress of protein-based dressing for wound healing applications – A review

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(15), P. 2402 - 2445

Published: July 17, 2024

Protein-based wound dressings have garnered increasing interest in recent years owing to their distinct physical, chemical, and biological characteristics. The intricate molecular composition of proteins gives rise unique characteristics, such as exceptional biocompatibility, biodegradability, responsiveness, which contribute the promotion healing. Wound healing is an ongoing process influenced by multiple causes, it consists four phases. Various treatments been developed repair different types skin wounds, thanks advancements medical technology recognition diverse nature wounds. This review has literature reviewed within last 3-5 years-the progress development protein fundamental properties ideal dressing. Herein, strides protein-based state-of-the-art dressing emphasize significant challenges summarize future perspectives for applications.

Language: Английский

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Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 28894 - 28909

Published: Oct. 9, 2024

Self-assembly of hydrogels for mechanical support and drug delivery has been extensively researched in traumatic brain injury (TBI), where treatment options are limited. The chief challenge is that most self-assembled rely on high molecular carriers or the incorporation exogenous inactive substances as mediators. It difficult these systems to achieve clinical translation due concerns regarding biological safety. Here we report a small molecule hydrogel (GBR-gel) loading drugs (glycyrrhizic acid, berberine, rhein) originated from popular Chinese medicines without additional components under physiological conditions. In long run, GBR-gel possesses several advantages, including ease preparation, cost-effectiveness, biocompatibility. As proof-of-concept, allows prompt administration at site exert potent pharmacodynamic effects. Further single-cell RNA sequencing experimental validation indicated can effectively rescue suppressed glutamatergic synapse pathway after TBI, thereby attenuating inflammatory responses neural impairments. Our work provides an alternative strategy timely intervention TBI.

Language: Английский

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Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing via precise immunoregulation

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Responsive hydrogels were capable of achieving the spatiotemporally controlled release polyphenol that relieved severe oxidative stress and modulated macrophage polarization, thus accelerating diabetic wound healing.

Language: Английский

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