Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 682, P. 653 - 670
Published: Nov. 29, 2024
Language: Английский
Aggregate, Journal Year: 2024, Volume and Issue: 5(4)
Published: March 10, 2024
Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.
Language: Английский
Citations
38
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 10, 2024
Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.
Language: Английский
Citations
17
Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150
Published: March 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Language: Английский
Citations
15
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 265 - 274
Published: March 2, 2024
Language: Английский
Citations
10
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 25, 2025
Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness can lead to systemic side effects. Photodynamic therapy (PDT) a photoresponsive cancer based on photosensitizers generate reactive oxygen species (ROS) eradicate tumor cells. Our previous study showed that exosomes derived from human γδ-T cells (γδ-T exosomes) could control Epstein–Barr virus-associated tumors. Here, we combined PDT for targeted photoimmunotherapy by membrane fusion Chlorin e6 (Ce6)-loaded liposomes. The functional surface proteins, such as CCR5 PD-1, hybrid mediated specific binding toward melanoma tissues. cytolytic molecules, granzyme A, B, perforin, granulysin exosomes, induced apoptosis without harming normal In response light irradiation, ROS generation inside synergized with molecules induce promote immunogenic cell death (ICD). subsequently released damage-associated molecular patterns (DAMPs) stimulate dendritic maturation antigen-specific CD4+ CD8+ T-cell responses, thereby enhancing antitumor immunity. This provides promising strategy combining photoimmunotherapy, expanding clinical applications exosome patients.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: July 21, 2024
Abnormal tumor metabolism creates a complex immune microenvironment that plays dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is insensitive to checkpoint blockade (ICB) therapy because insufficient cytotoxic T lymphocyte (CTL) infiltration and hyper-lactic acid-suppressive caused by abnormal glycolysis. Herein, we propose an amplified strategy based on lactic acid regulation reprogram immunosuppressive (ITM) combine it with ICB achieve enhanced antitumor immunotherapy effects. Specifically, constructed CASN, carrier-free photodynamic bioregulator, through self-assembly photosensitizer Chlorin e6 monocarboxylate transporter 1 (MCT1) inhibitor AZD3965. CASN exhibited uniform structure, good stability, drug accumulation at site. CASN-mediated following laser irradiation inhibited primary growth induced immunogenic cell death. Furthermore, reduced acid-mediated regulatory generation M2 tumor-associated macrophage polarization blocking MCT1-mediated efflux attenuate suppression, inducing recruitment activation CTLs. Ultimately, immunopotentiation combined considerably strengthened effectively TNBC. This synergistic amplification overcomes limitations acidic ITM presents potential clinical treatment option for metastatic tumors.
Language: Английский
Citations
8
RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13654 - 13668
Published: Jan. 1, 2024
The emission features of a novel bioactive compound, 1,3-bis(2-hydroxy-3,5-diiodophenyl-methylideneamino)guanidine is found impressive with aggregation induced enhancement. nitrogen and iodine rich multidentate proligand was characterized physicochemically. SCXRD Hirshfeld surface investigation have revealed the presence significant triangular bonding apart from hydrogen bonding, weak C-H⋯π π⋯π intermolecular interactions. These interactions collectively contribute to solid-state packing arrangement molecules within crystal lattice. band gap compound estimated experimentally supported theoretical calculations. fluorescence quantum yield
Language: Английский
Citations
6
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 3, 2024
Abstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile innovative nanoagents due to their structure‒function control, biological nature, simple preparation methods. This review article summarized the recent developments in multicomponent formed from metal interactions amino acids, peptides, proteins, together anticancer drugs, theranostics. We discussed role of functional groups anchored building blocks interactions, subsequently, types were examined a perspective. Amino acids different drugs forming mechanisms highlighted. Peptides proteins used material formations, activity discussed. Ultimately, conclusion future outlook offer fundamental fabrication design precision medicine.
Language: Английский
Citations
6
Advanced Optical Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 20, 2024
Abstract Commercial photosensitizers (PSs) present great potential in the field of clinical photodynamic therapy (PDT) yet face a formidable challenge owing to extremely short lifespan singlet oxygen ( 1 O 2 ). Herein, slow‐release “platform” is proposed based on an anthracene‐groups functionalized D‐π‐A system AIC ), which can capture and slowly release produced by commercial PSs. Meanwhile, reversible chemical process between demonstrated series optical experiments high‐resolution mass spectrum. Remarkably, virtue “platform”, sustaining mitochondrial autophagy cell apoptosis still take place when laser cut off with period irradiation, reducing side effect sustained irradiation. In general, construction platform opens up exciting opportunities for improving PDT
Language: Английский
Citations
4
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2505 - 2519
Published: Feb. 1, 2025
Photodynamic therapy (PDT) is a common cancer treatment strategy that combines the use of light, photosensitizer, and oxygen to precisely generate reactive species (ROS). However, efficacy this method limited by shallow tissue penetration short-wavelength lasers involved, combination with other treatments such as photothermal (PTT) or radiation requires additional instruments. A new dual approach using single laser could minimize procedure. Chlorin e6 (Ce6) loaded-NaYF4:Yb,Er@NaYF4:Yb,Nd upconversion nanoparticles@mesoporous silica@mesoporous polydopamine nanoparticles (U@MSC@MP NPs) were fabricated achieve PDT PTT 808 nm laser. The NaYF4:Yb,Er@NaYF4:Yb,Nd (UCNPs) coated mesoporous silica (MS) for Ce6-loading (MP) photosensitizer. effects measured ROS generation detection thermal camera, respectively; in vitro cytotoxicity studies vivo antitumor analysis tumor xenograft mouse models performed confirm effects. PDT-PTT UCNPs successfully synthesized emit photoluminescence spectra can be absorbed Ce6 induce effect. Significant was observed from U@MSC@MP NPs following irradiation 5 min, which corresponded intracellular human colorectal adenocarcinoma HT-29 cells. significantly reduced cell viability compared alone, demonstrating potential designed UCNPs. Moreover, confirmed effect no signs toxicity, supporting safety biocompatibility NPs. These findings suggest achieved This promising simplifying procedures clinical applications.
Language: Английский
Citations
0