Indian Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 41(6), P. 527 - 532
Published: Dec. 1, 2022
Language: Английский
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(9), P. 626 - 645
Published: June 7, 2024
Most patients with alcohol-associated liver disease (ALD) engage in heavy drinking defined as 4 or more drinks per day (56 g) 8 (112 week for women and 5 (70 15 (210 men. Although abstinence from alcohol after diagnosis of ALD improves life expectancy reduces the risk decompensation disease, few studies have evaluated whether treatment use disorders will reduce progression improve liver-related outcomes. In November 2021, National Institute Alcohol Abuse Alcoholism commissioned a task force that included hepatologists, addiction medicine specialists, statisticians, clinical trialists members regulatory agencies to develop recommendations design conduct trials evaluate effect use, particularly eliminate ALD. The conducted extensive reviews relevant literature on Findings were presented at one in-person meeting discussed over next 16 months final recommendations. As directly address this topic, 28 approved by all represent consensus expert opinions. Alcohol-associated is main cause morbidity mortality globally. This Consensus Statement makes design, best practice effects disorder.
Language: Английский
Citations
22
Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 43(1), P. 5 - 30
Published: Aug. 17, 2022
Abstract The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins through various chaperones enzymes residing within ER organelle. Perturbation in process ensues when overwhelmed protein exceeds handling capacity, leading to accumulation misfolded/unfolded lumen—a state being referred as stress. In turn, stress induces a gamut signaling cascades, termed “unfolded response” (UPR) that reinstates homeostasis panel gene expression modulation. This type UPR is usually deemed “adaptive UPR.” However, persistent or unresolved hyperactivates response, which ultimately, triggers cell death inflammatory pathways, “maladaptive/terminal A plethora evidence indicates crosstalks between (maladaptive UPR) inflammation precipitate obesity pathogenesis. this regard, acquisition mechanisms linking might unveil potential remedies tackle pathological condition. Herein, we aim elucidate key stress‐induced context summarize therapeutic strategies management maneuvering stress‐associated inflammation.
Language: Английский
Citations
57
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: July 22, 2022
Endometriosis is defined as the presence of endometrial-like glands and stroma located outside uterine cavity. This common, estrogen dependent, inflammatory condition affects up to 15% reproductive-aged women a well-recognized cause chronic pelvic pain infertility. Despite still unknown etiology endometriosis, much evidence suggests participation epigenetic mechanisms in disease etiopathogenesis. The main rationale based on fact that heritable phenotype changes do not involve alterations DNA sequence are common triggers for hormonal, immunological, disorders, which play key role formation endometriotic foci. Epigenetic regulating T-cell responses, including methylation posttranslational histone modifications, deserve attention because tissue-resident T lymphocytes work concert with organ structural cells generate appropriate immune responses functionally shaped by organ-specific environmental conditions. Thus, failure precisely regulate cell transcription may result compromised immunological integrity an increased risk disorders. coexistence endometriosis autoimmunity well-known occurrence. Recent research results indicate regulatory (Treg) number highly active Tregs macrophages have been found peritoneal fluid from endometriosis. Elimination function imbalance between helper Th1 Th2 types reported endometria endometriosis-associated review aims present state art recognition reprogramming factor pathophysiology context T-cell-related autoimmunity. new potential therapeutic approaches modulation and/or adoptive transfer will also be outlined.
Language: Английский
Citations
40
Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155814 - 155814
Published: June 12, 2024
Alcohol-associated liver disease (ALD) is a prevalent ailment. It has escalated into significant public health issue, imposing substantial burdens on medical, economic, and social domains. Currently, oxidative stress, inflammation, apoptosis are recognized as crucial culprits in improving ALD. Consequently, mitigating these issues emerged promising avenue for enhancing Hydroxysafflor yellow A (HSYA) the main ingredient safflower, showing excellent antioxidative anti-inflammatory, anti-apoptosis traits. However, there limited investigations mechanisms by which HSYA ameliorates ALD PURPOSE: We investigated whether HSYA, constituent of Asteraceae exerts antioxidant stress attenuates inflammation anti-apoptotic effects through PI3K/Akt STAT3/NF-κB pathways, thereby ameliorating METHODS: established two experimental models: an ethanol-induced damage mouse model vivo HepG2 cell alcohol injury vitro RESULTS: The results demonstrated that effectively ameliorated tissue damage, reduced levels ALT, AST, LDL-C, TG, TC, MDA, enhanced HDL-C levels, SOD GSH activities, ROS accumulation cells, activated Nrf2 pathway, transcription factor involved defense. By regulating exhibits notable effects, impeding ALD's advancement. To further confirm regulatory effect downstream signaling PI3K activator 740 Y-P was used found to reverse downregulation CONCLUSION: This study supports effectiveness reducing indicating its potential medicinal value.
Language: Английский
Citations
6
Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3537 - 3537
Published: July 27, 2024
Liver disease is a global health problem that affects the well-being of tens thousands people. Dihydroquercetin (DHQ) flavonoid compound derived from various plants. Furthermore, DHQ has shown excellent activity in prevention and treatment liver injury, such as inhibition hepatocellular carcinoma cell proliferation after administration, normalization oxidative indices (like SOD, GSH) this tissue, down-regulation pro-inflammatory molecules (such IL-6 TNF-α). also exerts its therapeutic effects by affecting molecular pathways NF-κB Nrf2. This paper discusses latest research progress diseases (including viral drug alcoholic non-alcoholic fatty immune injury). It explores how to optimize application improve effectiveness treating diseases, which valuable for preparing potential drugs human conjunction with DHQ.
Language: Английский
Citations
4
Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 251, P. 108547 - 108547
Published: Oct. 13, 2023
Language: Английский
Citations
10
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137367 - 137367
Published: Jan. 1, 2025
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: Jan. 27, 2025
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156522 - 156522
Published: Feb. 16, 2025
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: March 13, 2025
Language: Английский
Citations
0