Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Cellular senescence has emerged as one of the central hallmarks aging and drivers chronic comorbidities, including periodontal diseases. Senescence can also occur in younger tissues instigate metabolic alterations dysfunction, culminating accelerated pathological consequences. Senotherapeutics, such combination dasatinib quercetin (DQ), are being increasingly used to improve clinical outcomes disorders promote a healthy life span through reduction senescent cell burden senescence-associated secretory phenotype (SASP). Recent evidence suggests that cells SASP contribute pathogenesis diseases well. In this study, we investigated effect DQ interventions on tissue health using preclinical models aging. vitro, ameliorated biological signatures human gingival keratinocytes upon persistent exposure bacteria, Fusobacterium nucleatum, by modulating levels key markers p16, SA-β-galactosidase, lamin-B1 inflammatory mediators associated with interleukin-8, matrix metalloproteinase (MMP)–1, MMP-3. vivo, oral administration mitigated reduced naturally progressing bone loss aged mice. Collectively, our findings provide proof-of-concept for translational studies reveal targeting secretome be an effective strategy health, particularly vulnerable populations.
Language: Английский
Citations
1
Archives of Medicine and Health Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Abstract Inflammasomes are complex multimeric protein molecules that play a central role in orchestrating the inflammatory response within periodontal tissues. These structures, primarily located immune cells like macrophages and dendritic cells, become activated when exposed to microbial pathogens which commonly found dental plaque. Inflammasomes, crucial regulators of inflammation, significant diseases. Activation inflammasomes, particularly NOD-like receptor family, pyrin domain-containing 3, triggers release pro-inflammatory cytokines, exacerbating tissue destruction periodontium. The aim this review is comprehensively explore inflammasomes periodontology, elucidating their involvement diseases, discussing mechanisms inflammasome activation, evaluating potential as therapeutic targets. A comprehensive search was conducted across three databases, namely PubMed, Medline, Google Scholar, focusing on periodontology: Various terms including inflammasome, periodontitis, oral health, related keywords were employed identify relevant studies.
Language: Английский
Citations
0
Journal of Endodontics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cuadernos de Educación y Desarrollo, Journal Year: 2025, Volume and Issue: 17(4), P. e7926 - e7926
Published: April 4, 2025
Due to the characterization of Autism Spectrum Disorder (ASD) as a multifaceted syndrome, most diagnoses are still not precise. To avoid pharmacological treatments, natural strategies with significant potential reduce oxidative stress sought. This study aims identify influence quercetin on oral and gut microbiota, well evaluate action this bioactive compound in relation signs symptoms that characterize ASD individuals. research, is systematic review, was conducted PubMed platform from 2014 2024. The keywords used were: “quercetin autismo”; “autism, antioxidante”; microbiota”; intestinal microbiota.” Evidences showed reduces under various conditions, both vitro vivo, indicated mitochondrial function optimization protection against xenobiotic-induced damage. It demonstrated benefits such improved cognitive function, reduced blood glucose levels, activation SIRT1 enzyme. preserved microbial diversity dominance inflammatory taxonomic groups. positively influenced microbiota by decreasing Firmicutes increasing Bacteroidetes. could represent novel approach conditions related gut-brain-microbiota axis. Studies suggest offers promising mitigate physiological manifestation challenges, improve responses, act potent antioxidant, modulate microbiota. hoped attention these individuals will continue grow progressively.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1138 - 1138
Published: May 21, 2024
Diabetic retinopathy (DR) is one of the most severe complications diabetes mellitus and potentially leads to significant visual impairment blindness. The complex mechanisms involved in pathological changes DR make it challenging achieve satisfactory outcomes with existing treatments. Diets conducive glycemic control have been shown improve diabetic patients, thus positioning dietary interventions as promising avenues for treatment. Investigations demonstrated that natural products (NPs) may effectively manage DR. Many types compounds, including saponins, phenols, terpenoids, flavonoids, saccharides, alkaloids, vitamins, exert anti-inflammatory, antioxidant, anti-neovascular, antiapoptotic effects vivo vitro. Nevertheless, clinical application NPs still faces challenges, such suboptimal specificity, poor bioavailability, a risk toxicity. Prospective studies are imperative validate therapeutic potential delaying or preventing
Language: Английский
Citations
2
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2645 - 2645
Published: Nov. 19, 2024
Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113612 - 113612
Published: Nov. 22, 2024
Language: Английский
Citations
2
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(27), P. 2351 - 2361
Published: Aug. 28, 2024
: Diabetes mellitus poses a significant health challenge globally, often leading to debilitating complications, such as neuropathy and retinopathy. Quercetin, flavonoid prevalent in fruits vegetables, has demonstrated potential therapeutic effects these conditions due its antioxidant, anti-inflammatory, neuroprotective properties. This review summarizes provides comprehensive understanding of the molecular mechanisms underlying efficacy quercetin ameliorating diabetic A thorough search was carried out across scientific databases, SciFinder, PubMed, Google Scholar, gather pertinent literature regarding effect on retinopathy till February 2024. Preclinical studies indicate that mitigates neuropathic pain, sensory deficits, nerve damage associated with by improving neuronal function, reducing DNA damage, regulating pro-inflammatory cytokines, enhancing antioxidant enzyme levels endothelial well restoring injuries. In retinopathy, shows preserve retinal structure inhibiting neovascularization, preventing cell death, increasing neurotrophic factor levels. Moreover, through modulating key signaling pathways, AMP-activated Protein Kinase (AMPK) activation, Glucose Transporter 4 (GLUT 4) upregulation, insulin secretion regulation, demonstrates oxidative stress inflammation, thereby protecting tissues. Despite promising preclinical findings, challenges, limited bioavailability, necessitate further research optimize quercetin’s clinical application order establish optimal dosage, formulation, long-term settings.
Language: Английский
Citations
1
Frontiers in Dental Medicine, Journal Year: 2024, Volume and Issue: 5
Published: Oct. 14, 2024
Impaired bone healing is a significant complication observed in individuals with type 2 diabetes mellitus (T2DM), leading to prolonged recovery, increased risk of complications, impaired quality life, and patient morbidity. Oxidative stress, resulting from an imbalance between the generation reactive oxygen species (ROS) cellular/tissue antioxidant defence mechanisms, has been identified as critical contributor pathogenesis T2DM. Antioxidants have shown promise mitigating oxidative stress promoting repair, particularly non-enzymic entities. This comprehensive narrative review aims explore underlying mechanisms intricate relationship T2DM, specific focus on current preclinical clinical evidence advocating potential therapeutic interventions improving outcomes From ever-emerging available, it apparent that exogenously supplemented antioxidants, especially can ameliorate detrimental effects inflammation, cellular function processes during uncontrolled hyperglycaemia; therefore, hold considerable novel efficacious However, despite such conclusions, several important gaps our knowledge remain be addressed, including studies involving more sophisticated enzymic antioxidant-based delivery systems, further mechanistic into how these antioxidants exert their desirable reparative effects; extensive trial optimisation therapy dosing, frequency, duration subsequent biodistribution bioavailability. By enhancing understanding crucial issues, we fully exploit stress-neutralising properties develop effective mitigate reduce associated complications T2DM populations.
Language: Английский
Citations
1
Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0