Implications of glioblastoma-derived exosomes in modifying the immune system: state-of-the-art and challenges DOI

Yashmin Afshar,

Negin Sharifi,

Amirhossein Kamroo

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Glioblastoma is a brain cancer with poor prognosis. Failure of classical chemotherapy and surgical treatments indicates that new therapeutic approaches are needed. Among cell-free options, exosomes versatile extracellular vesicles (EVs) carry important cargo across barriers such as the blood-brain barrier (BBB) to their target cells. This makes an interesting option for treatment glioblastoma. Moreover, can comprise many cargos, including lipids, proteins, nucleic acids, sampled from special intercellular compartments origin cell. Cells exposed various immunomodulatory stimuli generate enriched in specific molecules. Notably, secretion could modify immune response innate adaptive systems. For instance, glioblastoma-associated (GBex) uptake by macrophages influence macrophage dynamics (e.g., shifting CD markers expression). Expression critical immunoregulatory proteins cytotoxic T-lymphocyte antigen-1 (CTLA1) programmed death-1 (PD-1) on GBex direct crosstalk these nano-size system. The present study reviews role system cells, B T natural killer (NK) dendritic cells (DCs), well novel technologies field.

Language: Английский

Mannose-modified erythrocyte membrane-coated Chuanmingshen violaceum polysaccharide PLGA nanoparticles to improve immune responses in mice DOI

Shuyao Yang,

Xinnan Zhang, Yao Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114450 - 114450

Published: March 12, 2025

Language: Английский

Citations

1
Multi-Drug Resistance and Breast Cancer Progression via Toll-Like Receptors (TLRs) Signaling DOI

Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hussein Zwamel

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3015 - 3030

Published: Aug. 7, 2024

Language: Английский

Citations

4
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis DOI
Yousef Tizabi, Marta C. Antonelli,

Daniela Tizabi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 27, 2025

Language: Английский

Citations

0
Minocycline Ameliorates Staphylococcus aureus-Induced Neuroinflammation and Anxiety-like Behaviors by Regulating the TLR2 and STAT3 Pathways in Microglia DOI Creative Commons

Jiao Zou,

Junwei Gao, Weilong Shang

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 128 - 128

Published: Jan. 28, 2025

Background: Anxiety disorders are the most common mental illnesses. S. aureus is a Gram-positive opportunistic pathogen commonly associated with anxiety-like behaviors. Minocycline ameliorates Gram-negative bacterial LPS-induced behaviors by suppressing microglia activation. However, effects of minocycline on caused infections have received little attention. In this study, we aimed to investigate molecular mechanism and effect infection. Methods: BV2 N9 microglial cells were treated in vitro. The lipoteichoic acid (LTA)-stimulated inflammatory responses, STAT3 activation, GLS1 expression assessed using Western blotting, cytokine secretion was determined an ELISA. A mouse model used evaluate capacity ameliorate Results: We found that ≥100 μmol/L remarkably attenuated LTA-induced TLR2 signaling pathway activation proinflammatory cells. prevented LTA-stimulated TLR2, TNF-α, IL-6, markedly reduced inhibition phosphorylation. Mice pretreated 50 mg/kg minocycline, significantly attenuating neuroinflammation. also effectively alleviated induced Conclusions: Our findings indicate alleviates infection-induced

Language: Английский

Citations

0
COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis DOI
Saba Fekrvand, Kiarash Saleki,

Hassan Abolhassani

et al.

Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 35

Published: April 3, 2025

Inborn errors of immunity (IEI) are congenital disorders the immune system. Due to impaired system, they at a higher risk develop more severe COVID-19 course compared general population. Herein, we aimed systematically review various aspects IEI patients infected with SARS-CoV-2. Moreover, performed meta-analysis determine frequency in different IEI. Embase, Web Science, PubMed, and Scopus were searched introducing terms related COVID-19. 3646 cases history infection enrolled. The majority had critical infections (1013 cases, 27.8%). highest was observed phenocopies (95.2%), defects intrinsic innate (69.4%) dysregulation (23.9%). 446 (12.2%) succumbed disease mortality (34.6%). immunodeficient 11.9% (95% CI: 8.3 15.5%) immunodeficiency having [34.1% (12.1 56.0%)]. case fatality rate among estimated as 5.4% 3.5-8.3%, n = 8 studies, I2 17.5%). underlying specific branches system responding RNA virus experience infection. Increasing awareness about these entities genetic defects, adherence prophylactic strategies allocating clinical attention could lead decrease patients.

Language: Английский

Citations

0
Porphyromonas gingivalis induces Zbp1-mediated macrophages PANoptosis in periodonitis pathophysiology DOI Creative Commons
Jing Qin Wu, Zixiang Guo, Long Wang

et al.

Experimental & Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Periodontitis is an oral immunoinflammatory disease, and macrophages play a crucial role in its pathophysiology. However, macrophage death during antibacterial activities will exacerbate inflammation tissue damage. Porphyromonas gingivalis major constituent of subgingival biofilm plaques periodontitis, but the effects precise molecular mechanisms by which it triggers remain unknown. Here we found that P. infection notably activated multiple pathways bone-marrow-derived macrophages, including pyroptosis, apoptosis necrosis. Furthermore, using RNA sequencing, identified markedly increased expression Z-DNA binding protein 1 (Zbp1) macrophages. Initially as interferon-induced tumor-associated protein, Zbp1 serves upstream sensor regulates cell activating PANoptosis. Mechanistically, induced mitochondrial stress response, prompting release DNA. This DNA then interacted with Zbp1, consequently augmenting downstream PANoptosis signals. In addition, stimulated through Tlr2/4-JNK-Stat3/5 pathway, exacerbating death. Importantly, blocking biosynthesis endogenous pharmacological delivery microneedles improved survival gingivalis-infected inhibited periodontal destruction. These findings highlight potential therapeutic target for gingivalis-induced periodontitis.

Language: Английский

Citations

0
Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders DOI
Veerta Sharma,

Prateek Sharma,

Thakur Gurjeet Singh

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Nanocarriers in glioblastoma treatment: a neuroimmunological perspective DOI
Faezeh Firuzpour, Kiarash Saleki, Cena Aram

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Glioblastoma multiforme (GBM) is the most fatal brain tumor with a poor prognosis current treatments, mainly because of intrinsic resistance processes. GBM also referred to as grade 4 astrocytoma, that makes up about 15.4 % cancers globally well 60-75 astrocytoma. The prevalent therapeutic choices for comprise surgery in combination radiotherapy and chemotherapy, providing patients an average survival 6-14 months. Nanocarriers provide various benefits such enhanced drug solubility, biocompatibility, targeted activity, minimized side effects. In addition, treatment comes several challenges presence blood-brain barrier (BBB), (BBTB), overexpressed efflux pumps, infiltration, invasion, resistance, immune escape due microenvironment (TME) cancer stem cells (CSC). Recent research has focused on nanocarriers their ability self-assemble, improve bioavailability, controlled release, penetrate BBB. These nano-based components could potentially enhance accumulation tissues reduce systemic toxicity, making them compelling solution therapy. This review captures complexities associated multi-functional nano delivery systems (NDDS) crossing (BBB) targeting cells. it presents succinct overview types system which exhibited promising value improving brain.

Language: Английский

Citations

3
One Path, Two Solutions: Network-Based Analysis Identifies Targetable Pathways for the Treatment of Comorbid Type II Diabetes and Neuropsychiatric Disorders DOI Creative Commons
Anna Onisiforou, Panos Zanos

Computational and Structural Biotechnology Journal, Journal Year: 2024, Volume and Issue: 23, P. 3610 - 3624

Published: Oct. 10, 2024

Language: Английский

Citations

1
Research status and prospects of pituitary adenomas in conjunction with neurological and psychiatric disorders and the tumor microenvironment DOI Creative Commons
Siyuan Cui, Sainan Chen, Xuechao Wu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 22, 2024

Patients with pituitary neuroendocrine tumors (PitNETs) often experience neuropsychiatric disorders due to factors such as hormonal imbalances, and inadequate management of medications, surgeries, radiation therapies. Commonly observed include depression, anxiety, cognitive dysfunction, which significantly impact patients’ quality life prognosis. PitNETs have a significant presence immune cells within the tumor microenvironment (TME), predominantly macrophages T lymphocytes. These secrete variety cytokines, growth factors, chemokines, regulate biological behaviors PitNETs, including initiation, proliferation, migration, invasion, angiogenesis. In addition, this review provides pioneering summary close relationships between aberrant secretion proinflammatory cytokines TME occurrence disorders, along their potential underlying mechanisms. The produced result dysregulation may affect various aspects central nervous system, neurotransmitter metabolism, function, neurovascular plasticity, thereby leading higher susceptibility neurobehavioral in PitNET patients.

Language: Английский

Citations

1