Biotechnological, Computational Analysis and Predictive Modeling of Phytochemicals in Moringa oleifera DOI Creative Commons
Terkuma Saaondo

Published: Dec. 8, 2023

Moringa oleifera, commonly known as the tree, has garnered considerable attention in recent years due to its abundant phytochemical composition with potential medicinal and nutritional benefits. This literature review presents a comprehensive exploration of interplay between computational analysis, predictive modeling, richness aiming elucidate applications medicine nutrition. The comprising flavonoids, phenolic compounds, vitamins, minerals, other bioactive constituents, forms foundation this investigation. Computational methods, including molecular docking, quantitative structure-activity relationship (QSAR) chemoinformatics, are scrutinized for their role characterizing predicting bioactivity oleifera phytochemicals. Predictive modeling techniques, encompassing machine learning algorithms regression evaluated utility forecasting bioactivity, toxicity, properties these Through synergy approaches, researchers gain insights into underscores significance relationships data-driven designing targeted interventions. It also highlights promising prospects drug development, functional foods, dietary supplements derived from oleifera. While progress been made, opportunities remain address research gaps, refine models, translate findings practical that promote human health provides foundational understanding transformative analysis harnessing wealth opening new avenues interdisciplinary pursuit advancements.

Language: Английский

Moringa oleifera Leaf Extract Promotes Healing of Infected Wounds in Diabetic Rats: Evidence of Antimicrobial, Antioxidant and Proliferative Properties DOI Creative Commons
Abdullah A. Al-Ghanayem, Mohammed S. Alhussaini, Mohammed Asad

et al.

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(5), P. 528 - 528

Published: April 25, 2022

Moringa oleifera is known to possess wound healing activity. The present study evaluated the properties of methanolic extract M. leaves in excision wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) or P. aeruginosa diabetic rats. An vitro was also carried out determine gene expression VEGF and TGF-β1. Preliminary phytochemical GC-MS analyses were different chemical constituents extract. applied locally as an ointment at two concentrations. Wound contraction, period epithelization, antioxidant enzyme activities histological changes determined. For study, HaCaT cell lines used. formulation improved contraction decreased which associated increase activities, capillary density collagen formation MRSA-infected However, this effect reduced animals aeruginosa. TGF-β1 observed lines. promotes rats but less effective

Language: Английский

Citations

51
Antioxidant, anticancer, and anti‐inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach DOI Creative Commons
Muhammad Shahbaz, Hammad Naeem, Maryam Batool

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(9), P. 6157 - 6173

Published: July 9, 2024

Abstract Moringa oleifera, a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including claimed ability counteract carcinogenesis. The moringa been found possess bioactive components that exhibit promising anticancer activities against different human cancers, such breast cancer, prostate pancreatic etc. cytotoxic properties of seed extracts on cancerous cells have also provided this paper along with other notable health benefits. derived from seeds inhibit cancer proliferation and promote cell apoptosis through multiple signaling pathways. They stimulated intracellular reactive oxygen species (ROS) production subsequently induced caspase‐3 activity. impact moringin avenanthramide 2f the stimulation caspases 2, 4, 8, 9 results reduction cells. reported by studies hold implications for identifying targeting specific molecular entities could serve potential therapeutic targets search effective treatments. Furthermore, flavonoids can remove mitochondrial species, protecting beta bringing hyperglycemia under control. M. oleifera oil reduce risk cardiovascular diseases via reduced malondialdehyde (MDA) formation modulation cardiac superoxide dismutase (SOD) glutathione peroxidase (GPx) This article provides comprehensive summary noteworthy discoveries rigorous investigation explored into prevention/reduction various cancers complex diseases.

Language: Английский

Citations

5
Moringa oleifera Lam.: A Phytochemical and Pharmacological Overview DOI Creative Commons
Attilio Anzano,

Mohammad Ammar,

Marina Papaianni

et al.

Horticulturae, Journal Year: 2021, Volume and Issue: 7(10), P. 409 - 409

Published: Oct. 16, 2021

Moringa oleifera Lam. is a fast-growing and drought-resistant tree of the Moringaceae family. The known with some common names: miracle, ben oil, drumstick, horseradish or simply moringa. plant grows in variety environments including harsh conditions. has high content phytonutrients, being used as natural integrators to cure malnutrition. Phytochemical studies organs showed rich source primary secondary metabolites belonging different classes organic compounds. Pharmacological confirmed use several diseases possess nutraceutical properties. This review aimed contribute knowledge M. by providing its description, phytochemistry pharmacology.

Language: Английский

Citations

30
Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets DOI Creative Commons

Yongbing Xu,

Guilin Chen, Mingquan Guo

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 10, 2022

Moringa oleifera ( M. ), widely used in tropical and subtropical regions, has been reported to possess good anti-aging benefits on skincare. However, the potential bioactive components responsible for its effects, including anti-collagenase, anti-elastase, anti-hyaluronidase activities, have not clarified so far. In this study, leaf extracts were first conducted anti-elastase anti-collagenase activities vitro by spectrophotometric fluorometric assays, results revealed that they possessed against skin aging-related enzymes. Then, multi-target bio-affinity ultrafiltration coupled high-performance liquid chromatography-mass spectrometry (AUF-HPLC-MS) was applied quickly screen ligands extracts. Meanwhile, 10, 8, 14 phytochemicals screened out as ligands, respectively. Further confirmation of these with target enzymes also implemented molecule docking analysis. conclusion, suggest leaves might be a very promising natural source agent skincare, which can further explored cosmetics cosmeceutical industries combating aging wrinkling.

Language: Английский

Citations

22
Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC–MS feature‐based molecular networking DOI
Zi Yang, Li Li, Chen‐Hui Chen

et al.

Phytochemical Analysis, Journal Year: 2022, Volume and Issue: 33(3), P. 473 - 489

Published: Jan. 18, 2022

Widespread use of antibiotics has led to an increase in bacterial multiple drug resistance, thereby searching for natural antimicrobial agents from plants becomes effective and alternative approach. In the present study, we selected six foodborne bacteria evaluate antibacterial activities 12 medicinal ethyl acetate (EA) extracts.This study aims search antibiotic substitutes plant extracts. The components were further discussed through chemometric mass spectroscopic analyses.Agar well diffusion microdilution methods used test activity. Total phenolic content (TPC) total flavonoid (TFC) judge active phytochemicals. To characterise potential components, ultra-performance liquid chromatography-quadrupole-time flight-mass spectrometry (UPLC-Q-TOF-MS) coupled with Pearson correlation feature-based molecular network (FBMN) proposed.Most extracts possessed activity against Bacillus subtilis Salmonella typhi. Toona sinensis shoots Firmiana simplex barks showed high inhibitory Staphylococcus aureus, Shigella dysenteriae, Escherichia coli strains minimum concentrations (MICs) 1.56, 0.78, 0.39 mg/mL, respectively. typhi was highly sensitive diameter up 21.67 ± 0.95 mm, MIC at 0.78 mg/mL. Moreover, had highest TPCs.Our results indicated that shoots, Koelreuteria paniculate seeds, could be supplied as sources agents. Furthermore, 36 bioactive compounds identified mainly polyphenols, glycosides, terpenoids.

Language: Английский

Citations

21
Chemical Analysis and Antimicrobial Activity of Moringa oleifera Lam. Leaves and Seeds DOI Creative Commons
Attilio Anzano, Bruna de Falco,

Mohammad Ammar

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(24), P. 8920 - 8920

Published: Dec. 15, 2022

Moringa oleifera is a traditional food crop widespread in Asiatic, African, and South American continents. The plant, able to grow harsh conditions, shows high nutritional value medicinal potential evidencing cardioprotective, anti-inflammatory, antioxidant, antimicrobial properties. purpose of this study was the phytochemical analysis M. identification compounds by combining chemical approach with vitro tests. metabolite profile polar apolar extracts leaves seeds were investigated using Nuclear Magnetic Resonance spectroscopy Gas Chromatography-Mass Spectrometry. activity all obtained extract evaluated against four bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa Salmonella enterica). provided wide set metabolites that identified quantified. Moreover, from showed significant concentration-dependent S. aureus (4 mg/mL reduced viability up 50%) associated content specific fatty acids. Our results remarked advantages an integrated for plant its use association biological tests recognize responsible bioactivity without purification.

Language: Английский

Citations

20
The properties and mechanism of action of plant immunomodulators in regulation of immune response – A narrative review focusing on Curcuma longa L., Panax ginseng C. A. Meyer and Moringa oleifera Lam DOI Creative Commons

Muggunna Balasubramaniam,

Sarah Sapuan,

Ilie Fadzilah Hashim

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28261 - e28261

Published: March 22, 2024

Herbal treatments have been utilized for millennia to cure a variety of ailments. There are over 20, 000 herbal remedies available treat cancer and other disease in humans. In Ayurveda, traditional plants having revitalizing nourishing characteristics known as "Rasayanas." They anti-inflammatory, anticancer, anti-microbicidal, antiviral, immunomodulatory effects on the immune system. Immunomodulation is mechanism through which body stimulates, suppresses, or boosts system maintain homeostasis. Plant-derived immunomodulators typically phytocompounds, including carbohydrates, phenolics, lipids, alkaloids, terpenoids, organosulfur, nitrogen-containing chemicals. activity phytocompounds from primarily mediated macrophage activation, phagocytosis stimulation, peritoneal lymphoid cell suppression enhancement specific non-specific cellular systems via numerous signalling pathways. Despite extensive research, precise immunomodulation most has not yet fully elucidated, justifying need further experimentation. Therefore, this review describes agents such Curcuma longa L., Panax ginseng C.A. Meyer, Moringa oleifera Lam, highlighting common molecular targets involved eradicating diseases.

Language: Английский

Citations

4
Network pharmacology combined with molecular docking to explore the potential mechanisms for the antioxidant activity of Rheum tanguticum seeds DOI Creative Commons
Lingling Wang,

Feng Xiong,

Shuo Zhao

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2022, Volume and Issue: 22(1)

Published: May 3, 2022

Abstract Background Rheum tanguticum ( R. ) is an edible and medicinal plant that exhibits high antioxidant activity. The purpose of the present study was to investigate bioactive components its seeds potential mechanisms activity provide a foundation for further developmental work on R . as functional food. Methods In this study, activities were measured using DPPH, ABTS FRAP assays. LC-Q-TOF/MS used identify active compounds in seeds, Swiss Target Prediction their targets. DisGENET, DrugBank, OMIM GeneCard databases search antioxidant-related Results component–target–pathway network constructed included 5 9 target genes. hub genes ESR1, APP, MAPK8, HSP90AA1, AKT1, MMP2, PTGS2, TGFB1 JUN. signaling pathways treatment diseases cancer pathway, estrogen colorectal MAPK etc. Molecular docking revealed could inhibit targets (AKT1, ESR1 PTGS2). Conclusion studies binding energy score between liriodenine PTGS2 highest (8.16), followed by chrysophanol (7.10). This result supports PTGS2-targeted drug screening design.

Language: Английский

Citations

18
Evaluation of antioxidant activity, phenolic compound profile and accelerated storage of chestnut based mixed pulp powders DOI
Rosenildo dos Santos Silva, Rossana Maria Feitosa de Figueirêdo, Alexandre José de Melo Queiroz

et al.

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Antioxidant and antiproliferative potential of ethanolic extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in colorrectal cancer cells DOI Creative Commons
Marco Fuel, Cristina Mesas, Rosario Martínez

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112248 - 112248

Published: Sept. 30, 2021

Moringa oleifera, Tropaeolum tuberosum and Annona cherimola are medicinal plants traditionally used in Ecuador. However, their therapeutic properties not completely known. We analyzed chromatographically ethanolic extracts of the seeds M. A. tubers T. tuberosum; all presented a high content polyphenols. The extract showed highest antioxidant activity oleifera had capacity to enhance detoxifying enzymes such as glutathione S-transferase quinone oxidoreductase. antitumor effect these was evaluated vitro with colorectal cancer (CRC) cell lines T84, HCT-15, SW480 HT-29, well stem cells (CSCs). lowest IC50 T-84 HCT-15 (resistant) cells, respectively, level inhibition proliferation multicellular tumor spheroids cells. inhibitory on CSCs is noteworthy because vivo, often responsible for recurrences resistance chemotherapy. Moreover, synergistic 5-Fu. antiproliferative mechanism related overexpression caspases 9, 8 3 increased production reactive oxygen species. In addition, we observed death by autophagy extracts. Therefore, excellent candidates future molecular analysis presence bioactive compounds vivo studies which could improve colon therapy.

Language: Английский

Citations

23