Eucalyptus torquata seeds: Investigation of phytochemicals profile via LC-MS and its potential cardiopreventive capacity in rats

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103666 - 103666

Published: Jan. 24, 2024

Language: Английский

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Sequencing and analysis of the complete mitochondrial genomes of Toona sinensis and Toona ciliata reveal evolutionary features of Toona

BMC Genomics, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 1, 2023

Toona is a critical genus in the Meliaceae, and plants of this group are an asset for both restorative purposes, most flexible which sinensis ciliata. To concentrate on advancement mitochondrial(Mt) genome variety T.sinensis T.ciliata, Mt genomes two species were sequenced high throughput independently, after de novo assembly annotation to construct map comparison structure. Find their repetitive sequences analyze them with chloroplast genome, along Maximum-likelihood(ML) phylogenetic analysis 16 other relatives.(1) T. T.ciliata circular structures lengths 683482 bp 68300 bp, respectively. They share degree similarity encoding genes have AT preferences. All largest Phe concentration frequently used codons. (2) Both highly preserved terms structural functional genes, while main variability reflected length tRNA, number value RSCU. (3) siniensis ciliata detected 94 87 SSRs, respectively, mononucleotides accounted absolute proportion. Besides, vast majority SSRs found be poly-A or poly-T. (4)10 11 migrating fragments identified (5) In ML evolutionary tree, clustered individually into small branch 100% support, reflecting very similarly related each other.This research provides basis exploitation medicinal, edible, timber resources avoid confusion; at same time, it can explore relationship between species, does not only important practical value, but also theoretical future hybrid breeding forest trees, molecular markers, aspects plants, has great scientific significance.

Language: Английский

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The promising guide to LC–MS analysis and cholinesterase activity of Luffa cylindrica (L.) fruit using in vitro and in-silico analyses

Future Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 11, 2023

Abstract Background Luffa cylindrica (L.) is an annual climbing plant that produces fibrous fruit and can also be used as a vegetable in northern parts of India. Various studies have been carried out on the found to anti-inflammatory, antifungal, analgesic, anti-myocardial, anti-hyper triglyceride, immunostimulant, anti-allergic, other properties. The ethanolic extract has not yet subjected LC–MS analysis for several bioactive chemicals target neurological diseases. Oxidative stress inevitable situation AD mechanisms key bridge connecting various pathways. Results contains phytochemicals showed highest alkaloid content 21.39 ± 1.47 mg AE/g. A total 80 compounds were identified from analysis. screened eligibility by Lipinski's rule five docking with receptors responsible causing oxidative stress-associated Alzheimer's disease. Perlolyrine was chosen perform in-silico docking. An vitro activity cholinesterase inhibition at 500 µg/ml. In-silico perlolyrine better binding affinity score. revealed 10 docked receptors, amyloid beta energy − 46.1 kcal/mol showing promising drug Conclusion Based current findings, study reports presence promising, compound (perlolyrine) turn provides optimistic note exploring its biological vivo stress-related

Language: Английский

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An integrated strategy combining network toxicology and feature-based molecular networking for exploring hepatotoxic constituents and mechanism of Epimedii Folium-induced hepatotoxicity in vitro

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 176, P. 113785 - 113785

Published: April 19, 2023

Language: Английский

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Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 718 - 718

Published: Feb. 4, 2024

Toona sinensis (A. Juss.) Roem., which is widely distributed in China, a homologous plant resource of medicine and food. The leaves, seeds, barks, buds pericarps T. can be used as with traditional efficacy. Due to its extensive use the ancient world, has significant development potential. In this review, 206 compounds, including triterpenoids (1–133), sesquiterpenoids (134–135), diterpenoids (136–142), sterols (143–147), phenols (148–167), flavonoids (168–186), phenylpropanoids (187–192) others (193–206), are isolated from plant. mass spectrum cracking laws representative compounds (64, 128, 129, 154–156, 175, 177, 179 183) reviewed, conducive discovery novel active substances. Modern pharmacological studies have shown that extracts their antidiabetic, antidiabetic nephropathy, antioxidant, anti-inflammatory, antitumor, hepatoprotective, antiviral, antibacterial, immunopotentiation other biological activities. uses, chemical constituents, compound activities different parts laying foundation for improving utilization medicinal value.

Language: Английский

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Untargeted Characterization and Biological Activity of Amazonian Aqueous Stem Bark Extracts by Liquid and Gas Chromatography–Mass Spectrometry

Phytochemical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

ABSTRACT Introduction Aqueous stem bark extracts of Aspidosperma rigidum Rusby, Couroupita guianensis Aubl., Monteverdia laevis (Reissek) Biral, and Protium sagotianum Marchand have been reported as traditional remedies in several countries the Amazonian region. Despite previous research, further investigation to characterize secondary metabolites biological activity is needed derive potential applications. Material Methods Metabolic profiling was carried out using liquid gas chromatography coupled with mass spectrometry (UHPLC–MS/MS GC–MS). The chemical composition studied plants compared by principal component analysis (PCA). Additionally, profiles were correlated antimicrobial toxicity activities, which suggested for future research. Results We identified 16 32 compounds UHPLC–MS/MS GC–MS analysis, respectively. Antimicrobial detected three extracts. C. showed inhibition all tested microorganisms, including antibiotic‐resistant strains. Molecular networking approaches, silico tools, Pearson's correlation that antifungal could be a terpene glycoside ( r = 0.918) and/or phenolic 0.882) metabolite class. Conclusion This study highlights use established procedure exploring metabolomes these species, novel source drug discovery. Coupling observed data has also accelerated tracing their bioactive compounds. These findings update state art regarding plant extracts, defining new applications pharmaceutical

Language: Английский

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Antibacterial and antibiofilm activities and mechanisms of Toona sinensis extracts against Bacillus cereus and its application in milk

Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101045 - 101045

Published: April 1, 2025

Language: Английский

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Unraveling anti-aging mystery of green tea in C. elegans: Chemical truth and multiple mechanisms

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140510 - 140510

Published: July 17, 2024

Language: Английский

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The chemical composition, antioxidative and antimicrobial potentials of Toona sinensis essential oils from different regions of China

Journal of Essential Oil Bearing Plants, Journal Year: 2024, Volume and Issue: 27(5), P. 1377 - 1393

Published: Sept. 2, 2024

AbstractToona sinensis is one of the traditional Chinese medicinal materials with rich physiological activities. This study aimed to investigate chemical composition differences essential oils from tender leaves and shoots T. sinensis, collected four main producing areas in China, verify their anti-listeria antioxidant properties. Gas chromatography-mass spectrometry (GC-MS) analysis was conducted on obtained by hydro-distillation. The results indicated that compounds such as β-elemene (3.5∼8.1%), α-caryophyllene (3.7∼7.2%), trans-caryophyllene (4.0∼9.7%) were common components (TSEO) areas. DPPH ABTS showed oil Dazhou, Sichuan, China had best effect. At a concentration 1.25 mg/mL, activity TSEO-DZ Sichuan comparable 0.08 mg/mL BHT only slightly lower than 0.06 VC. broth dilution method Tai 'an, Shandong, better antibacterial effect, minimum inhibitory (MIC) bactericidal (MLC) values μL/mL 2.54 μL/mL, respectively. demonstrates TSEO possesses promising application potential activities, it confirms growth environment significantly influences quality, content, biological oil.Keywords: Antioxidant propertiesAnti-listeria activityEssential oilPrincipal component analysisToona

Language: Английский

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Multiple approaches to characterize and visualize the chemical composition of Sijunzi Decoction comprehensively

Journal of Separation Science, Journal Year: 2023, Volume and Issue: 46(8)

Published: Feb. 21, 2023

Sijunzi Decoction is composed of Ginseng Radix et Rhizoma, Atractylodes Macrocephalae Poria, and Glycyrrhizae Et Rhizoma Praeparata Cum Melle, it a classic formula for treating spleen deficiency syndrome in Chinese medicine. Clarifying the active substances an effective way to develop Traditional medicine innovative medicines. Carbohydrates, proteins, amino acids, saponins, flavonoids, phenolic inorganic elements decoction were analyzed by multiple approaches. A molecular network was also used visualizing ingredients Decoction, representative components quantified. The detected accounted 74.544% freeze-dried powder, including 41.751% crude polysaccharides, 17.826% sugars (degree polymerization 1-2), 8.181% total 2.427% insoluble precipitates, 2.154% free 1.177% 0.546% 0.483% elements. Molecular quantitative analysis characterize chemical composition Decoction. present study systematically characterized constituents revealed ratio each type constituent, provided reference on substance basis other

Language: Английский

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