Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(27)
Published: March 7, 2024
Abstract
Hydrogel
coatings,
with
natural
tissue‐like
mechanical
and
biological
compatibility,
demonstrate
promise
for
bulk
material
applications.
However,
existing
coating
methods
lack
efficiency
control,
especially
when
dealing
complex
geometries,
diverse
substrate
materials,
varying
sizes.
In
this
study,
an
enzyme‐immobilized
surface‐catalyzed
cross‐link
approach
is
proposed
the
growth
of
hydrogel
coatings
on
multiple
substrates,
accommodating
various
materials
shapes.
The
formed
through
catalytic
action
interface‐immobilized
enzymes,
which
induce
crosslinking
hyaluronic
acid,
its
properties
are
further
enhanced
by
introducing
a
secondary
polyacrylamide
network.
This
enables
controlled
conformal
double
network
desired
thickness
wide
range
surfaces
devices.
Notably,
exhibits
remarkable
lubricity
anti‐thrombotic
properties,
desire
medical
intervention
advancement
offers
universal
route
to
impart
biocompatible
soft
interfaces
or
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(6), P. 8662 - 8676
Published: May 13, 2022
Adhesive-caused
injury
is
a
great
threat
for
infants
with
premature
skin
or
diabetic
patients
fragile
because
extra-strong
adhesion
might
incur
pain,
inflammation,
and
exacerbate
trauma
upon
removal.
Herein,
we
present
skin-friendly
adhesive
hydrogel
patch
based
on
protein–polyphenol
complexation
strategy,
which
leads
to
thermoresponsive
network
sensitive
body
temperature.
The
of
the
smartly
activated
after
contacting
warm
skin,
whereas
painless
detachment
easily
realized
by
placing
an
ice
bag
surface
hydrogel.
exhibits
immunomodulatory
performance
that
prevents
irritation
allergic
reactions
during
long-period
contact
skin.
Thus,
works
as
conformable
nonirritating
interface
guarantee
nondestructively
securing
bioelectronics
infant
healthcare.
Furthermore,
provides
gentle
wounded
favorable
environment
speed
up
healing
process
managing
wounds.
iScience,
Journal Year:
2021,
Volume and Issue:
24(11), P. 103174 - 103174
Published: Sept. 27, 2021
Skin-like
electronics
are
developing
rapidly
to
realize
a
variety
of
applications
such
as
wearable
sensing
and
soft
robotics.
Hydrogels,
biomaterials,
have
been
studied
intensively
for
skin-like
electronic
utilities
due
their
unique
features
softness,
wetness,
biocompatibility
ionic
capability.
These
could
potentially
blur
the
gap
between
biological
systems
hard
artificial
machines.
However,
development
hydrogel
devices
is
still
in
its
infancy
faces
challenges
including
limited
functionality,
low
ambient
stability,
poor
surface
adhesion,
relatively
high
power
consumption
(as
sensors).
This
review
aims
summarize
current
skin-inspired
address
these
challenges.
We
first
conduct
an
overview
hydrogels
existing
strategies
increase
toughness
conductivity.
Next,
we
describe
approaches
leverage
with
advanced
merits
anti-dehydration,
anti-freezing,
adhesion.
Thereafter,
highlight
state-of-the-art
electronics,
robotics,
energy
harvesting.
Finally,
conclude
outline
future
trends.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(5), P. 5068 - 5143
Published: Dec. 28, 2021
Recent
advances
in
nanostructured
materials
and
unconventional
device
designs
have
transformed
the
bioelectronics
from
a
rigid
bulky
form
into
soft
ultrathin
brought
enormous
advantages
to
bioelectronics.
For
example,
mechanical
deformability
of
thus
its
conformal
contact
onto
curved
organs
such
as
brain,
heart,
skin
allowed
researchers
measure
high-quality
biosignals,
deliver
real-time
feedback
treatments,
lower
long-term
side-effects
vivo.
Here,
we
review
various
materials,
fabrication
methods,
strategies
for
flexible
stretchable
electronics,
especially
focusing
on
biointegrated
electronics
using
nanomaterials
their
composites.
First,
summarize
top-down
material
processing
bottom-up
synthesis
methods
nanomaterials.
Next,
discuss
state-of-the-art
technologies
intrinsically
nanocomposites
composed
incorporated
elastomers
or
hydrogels.
We
also
briefly
design
Then
individual
components
bioelectronics,
biosensing,
data
storage,
display,
therapeutic
stimulation,
power
supply
devices,
are
introduced.
Afterward,
representative
application
examples
described.
A
brief
summary
with
discussion
remaining
challenges
concludes
review.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
19, P. 360 - 375
Published: April 26, 2022
The
high
demand
for
rapid
wound
healing
has
spurred
the
development
of
multifunctional
and
smart
bioadhesives
with
strong
bioadhesion,
antibacterial
effect,
real-time
sensing,
wireless
communication,
on-demand
treatment
capabilities.
Bioadhesives
bio-inspired
structures
chemicals
have
shown
unprecedented
adhesion
strengths,
as
well
tunable
optical,
electrical,
bio-dissolvable
properties.
Accelerated
been
achieved
via
directly
released
growth
factors,
material
or
drug-induced
host
immune
responses,
delivery
curative
cells.
Most
recently,
integration
biosensing
modules
units
in
a
closed-loop
system
yielded
bioadhesives,
allowing
sensing
physiological
conditions
(e.g.,
pH,
temperature,
uric
acid,
glucose,
cytokine)
iterative
feedback
drastically
enhanced,
stage-specific
by
triggering
drug
to
avoid
infection
prolonged
inflammation.
Despite
advances
burgeoning
field,
challenges
still
exist
design
fabrication
integrated
systems,
particularly
chronic
wounds,
presenting
significant
opportunities
future
next-generation
materials
systems.
Materials Horizons,
Journal Year:
2022,
Volume and Issue:
9(5), P. 1356 - 1386
Published: Jan. 1, 2022
Organohydrogels
are
attractive
for
constructing
various
flexible
devices
with
good
environmental
tolerance
and
smart
materials.
Their
significant
developments
in
preparation,
performance
optimization
application
systematically
reviewed.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(31)
Published: Sept. 15, 2022
Achieving
robust
underwater
adhesion
by
bioadhesives
remains
a
challenge
due
to
interfacial
water.
Herein
coacervate-to-hydrogel
strategy
enhance
water
repulsion
and
bulk
of
is
reported.
The
polyethyleneimine/thioctic
acid
(PEI/TA)
coacervate
deposited
onto
substrates,
which
can
effectively
repel
completely
spread
into
substrate
surface
irregularities
its
liquid
water-immiscible
nature.
physical
interactions
between
further
adhesion.
Furthermore,
driven
the
spontaneous
hydrophobic
aggregation
TA
molecules
strong
electrostatic
interaction
PEI
TA,
turn
hydrogel
in
situ
within
minutes
without
additional
stimuli
develop
enhanced
matrix
cohesion
on
diverse
substrates.
Molecular
dynamics
simulations
reveal
atomistic
details
formation
wet
PEI/TA
via
multimode
interactions.
Lastly,
it
demonstrated
that
coacervate-derived
blood
therefore
efficiently
deliver
carried
growth
factors
at
wound
sites,
thereby
enhancing
healing
an
animal
model.
advantages
including
body
fluid-immiscibility,
adhesion,
adaptability
fit
irregular
target
excellent
biocompatibility
make
promising
bioadhesive
for
biomedical
applications.
Journal of Polymer Science,
Journal Year:
2022,
Volume and Issue:
60(18), P. 2607 - 2634
Published: Jan. 28, 2022
Abstract
Flexible
sensors
have
great
potential
in
the
application
of
wearable
and
implantable
devices,
conductive
hydrogels
been
widely
used
sensing
devices
due
to
their
biomimetic
structure,
biocompatibility,
adjustable
transparency
stimuli‐responsive
electrical
properties.
Conventional
are
prone
be
damaged
process
lack
long‐term
reliability.
Inspired
by
natural
organisms
such
as
mussels,
introduction
self‐healing
capabilities
has
regarded
a
promising
approach
extend
service
life
hydrogel
devices.
This
work
reviews
synthesis
methods
associated
mechanisms
representative
hydrogels.
The
principles
structural
design
also
reviewed
applications
for
vivo
/
vitro
signal
monitoring
introduced.
remaining
challenges
perspectives
this
field
discussed
order
direct
future
research
on
integration
capabilities,
good
properties
excellent
mechanical
performances
into
flexible
sensors.
