Food Frontiers,
Journal Year:
2020,
Volume and Issue:
1(1), P. 18 - 44
Published: March 1, 2020
Abstract
Dietary
polyphenols
have
been
widely
investigated
as
antidiabetic
agents
in
cell,
animals,
human
study,
and
clinical
trial.
The
number
of
publication
(Indexed
by
Web
Science)
on
“polyphenols
diabetes”
significantly
increased
since
2010.
This
review
highlights
the
advances
opportunities
dietary
agents.
prevent
manage
Type
2
diabetes
mellitus
via
insulin‐dependent
approaches,
for
instance,
protection
pancreatic
islet
β‐cell,
reduction
β‐cell
apoptosis,
promotion
proliferation,
attenuation
oxidative
stress,
activation
insulin
signaling,
stimulation
pancreas
to
secrete
insulin,
well
insulin‐independent
approaches
including
inhibition
glucose
absorption,
digestive
enzymes,
regulation
intestinal
microbiota,
modification
inflammation
response,
formation
advanced
glycation
end
products.
Moreover,
ameliorate
diabetic
complications,
such
vascular
dysfunction,
nephropathy,
retinopathy,
neuropathy,
cardiomyopathy,
coronary
diseases,
renal
failure,
so
on.
structure–activity
relationship
is
still
not
clear.
individual
flavonoid
or
isoflavone
has
no
therapeutic
effect
patients,
although
data
are
very
limited.
Resveratrol,
curcumin,
anthocyanins
showed
activity
study.
How
hyperglycemia
influences
bioavailability
bioactivity
understood.
An
understanding
how
alters
will
lead
an
improvement
their
benefits
outcomes.
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(11), P. 1092 - 1092
Published: Nov. 6, 2020
Antioxidant
potential
is
defined
as
the
ability
to
neutralize
oxygen
free
radicals
that
are
generated
in
excess
due
environmental
influences.
The
body's
defense
mechanisms
often
require
support
preventing
effects
of
oxidative
stress.
literature
data
suggest
curcumin
has
antioxidant
activity
can
significantly
reduce
stress
levels.
aim
was
assess
impact
on
markers.PubMed
and
Embase
were
searched
from
database
inception
until
27
September
2019
for
randomized
clinical
trials
>20
patients
treated
with
supplements
placebo/no
intervention/physical
verify
curcumin.Four
studies
included
meta-analysis,
three
which
double-blind
one
single-blind.
A
total
308
participants
took
part
research.
40%
respondents
men.
average
age
27.60
±
3.79
years.
supplementation
time
67
days
dose
administered
645
mg/24
h.
Curcumin
increased
capacity
(TAC)
(SMD
=
2.696,
Z
2.003,
CI
95%,
p
0.045)
had
a
tendency
decrease
malondialdehyde
(MDA)
concentration
-1.579,
-1.714,
0.086).Pure
MDA
increase
capacity.
Frontiers in Endocrinology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 3, 2021
Diabetes
mellitus
(DM)
is
an
ensemble
of
metabolic
conditions
that
have
reached
pandemic
proportions
worldwide.
Pathology's
multifactorial
nature
makes
patient
management,
including
lifelong
drug
therapy
and
lifestyle
modification,
extremely
challenging.
Currently,
there
growing
evidence
about
the
effectiveness
using
herbal
supplements
in
preventing
controlling
DM.
Curcumin
a
bioactive
component
found
Curcuma
longa,
which
exhibits
several
physiological
pharmacological
properties
such
as
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective,
anti-diabetic
activities.
For
these
reasons,
our
objective
to
systematically
review
effects
longa
or
curcumin
on
Databases
PUBMED
EMBASE
were
searched,
final
selection
included
sixteen
studies
fulfilled
inclusion
criteria.
The
results
showed
curcumin's
activity
might
be
due
its
capacity
suppress
oxidative
stress
inflammatory
process.
Also,
it
significantly
reduces
fasting
blood
glucose,
glycated
hemoglobin,
body
mass
index.
Nanocurcumin
also
associated
with
significant
reduction
triglycerides,
VLDL-c,
total
cholesterol,
LDL-c,
HDL-c,
serum
C
reactive
protein,
plasma
malonaldehyde.
Therefore,
can
considered
therapeutic
approach
patients
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(12), P. 10713 - 10746
Published: March 13, 2023
Curcumin
has
been
credited
with
a
wide
spectrum
of
pharmacological
properties
for
the
prevention
and
treatment
several
chronic
diseases
such
as
arthritis,
autoimmune
diseases,
cancer,
cardiovascular
diabetes,
hemoglobinopathies,
hypertension,
infectious
inflammation,
metabolic
syndrome,
neurological
obesity,
skin
diseases.
However,
due
to
its
weak
solubility
bioavailability,
it
limited
potential
an
oral
medication.
Numerous
factors
including
low
water
solubility,
poor
intestinal
permeability,
instability
at
alkaline
pH,
fast
metabolism
contribute
curcumin's
bioavailability.
In
order
improve
different
formulation
techniques
coadministration
piperine,
incorporation
into
micelles,
micro/nanoemulsions,
nanoparticles,
liposomes,
solid
dispersions,
spray
drying,
noncovalent
complex
formation
galactomannosides
have
investigated
in
vitro
cell
culture
models,
vivo
animal
humans.
current
study,
we
extensively
reviewed
clinical
trials
on
various
generations
curcumin
formulations
their
safety
efficacy
many
We
also
summarized
dose,
duration,
mechanism
action
these
formulations.
critically
advantages
limitations
each
compared
placebo
and/or
available
standard
care
therapies
ailments.
The
highlighted
integrative
concept
embodied
development
next-generation
helps
minimize
bioavailability
issues
least
or
no
adverse
side
effects
provisional
new
dimensions
presented
this
direction
may
add
value
cure
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4476 - 4476
Published: Feb. 24, 2023
Medicinal
properties
of
turmeric
(Curcuma
longa
L.),
a
plant
used
for
centuries
as
an
anti-inflammatory,
are
attributed
to
its
polyphenolic
curcuminoids,
where
curcumin
predominates.
Although
“curcumin”
supplements
top-selling
botanical
with
promising
pre-clinical
effects,
questions
remain
regarding
biological
activity
in
humans.
To
address
this,
scoping
review
was
conducted
assess
human
clinical
trials
reporting
oral
effects
on
disease
outcomes.
Eight
databases
were
searched
using
established
guidelines,
yielding
389
citations
(from
9528
initial)
that
met
inclusion
criteria.
Half
focused
obesity-associated
metabolic
disorders
(29%)
or
musculoskeletal
(17%),
inflammation
is
key
driver,
and
beneficial
outcomes
and/or
biomarkers
reported
most
(75%)
studies
primarily
double-blind,
randomized,
placebo-controlled
(77%,
D-RCT).
Citations
the
next
studied
categories
(neurocognitive
[11%]
gastrointestinal
[10%],
cancer
[9%]),
far
fewer
number
yielded
mixed
results
depending
study
quality
condition
studied.
additional
research
needed,
including
systematic
evaluation
diverse
formulations
doses
larger
D-RCT
studies,
preponderance
current
evidence
several
highly
diseases
(e.g.,
syndrome,
osteoarthritis),
which
also
clinically
common,
suggestive
benefits.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: April 1, 2024
Abstract
At
present,
diabetes
mellitus
(DM)
has
been
one
of
the
most
endangering
healthy
diseases.
Current
therapies
contain
controlling
high
blood
sugar,
reducing
risk
factors
like
obesity,
hypertension,
and
so
on;
however,
DM
patients
inevitably
eventually
progress
into
different
types
complications,
resulting
in
poor
quality
life.
Unfortunately,
clear
etiology
pathogenesis
complications
have
not
elucidated
owing
to
intricate
whole‐body
systems.
The
immune
system
was
responsible
regulate
homeostasis
by
triggering
or
resolving
inflammatory
response,
indicating
it
may
be
necessary
complications.
In
fact,
previous
studies
shown
inflammation
plays
multifunctional
roles
is
attracting
attention
meaningful
therapeutic
strategy.
To
this
end,
review
systematically
concluded
current
over
relationships
susceptible
(e.g.,
diabetic
cardiomyopathy,
retinopathy,
peripheral
neuropathy,
nephropathy)
inflammation,
ranging
from
cell
cytokines
interaction
pathomechanism
organ
injury.
Besides,
we
also
summarized
various
strategies
improve
target
special
remedies
conventional
lifestyle
changes.
This
will
offer
a
panoramic
insight
mechanisms
an
perspective
discuss
contemporary
clinical
interventions.
