Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4928 - 4928

Published: April 28, 2022

Chronic inflammation is one of the hallmarks chronic wounds and tightly coupled to immune regulation. The dysregulation system leads continuing impaired wound healing and, subsequently, skin wounds. In this review, we discuss role system, involvement inflammatory mediators reactive oxygen species, complication bacterial infections in healing, still-underexplored potential natural bioactive compounds treatment. We focus on with antioxidant, anti-inflammatory, antibacterial activities their mechanisms action, as well recent treatments therapeutic advancements capitalizing nanotechnology or new biomaterial platforms.

Language: Английский

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Role of Oxidative Stress in Diabetic Cardiomyopathy

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 784 - 784

Published: April 15, 2022

Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes-specific mechanisms contribute prominent oxidative distress in the heart, resulting development diabetic cardiomyopathy. Mitochondrial overproduction reactive oxygen species subjects not only caused by intracellular hyperglycemia microvasculature but also result increased fatty oxidation lipotoxicity cardiomyocytes. superoxide anion radicals induces, via inhibition glyceraldehyde 3-phosphate dehydrogenase, an polyol pathway flux, formation advanced glycation end-products (AGE) activation receptor for AGE (RAGE), protein kinase C isoforms, hexosamine flux. These pathways directly cardiomyopathy are themselves source additional species. Reactive lead cell dysfunction cellular injury oxidation, lipid peroxidation, DNA damage, changes microRNAs stress-sensitive regulation. Investigations animal models have consistently demonstrated that expression primary antioxidant enzymes attenuates myocardial pathology improves cardiac function.

Language: Английский

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Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4278 - 4278

Published: July 3, 2022

Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence diabetes worldwide has led to the development several synthetic drugs tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible majority living in underdeveloped countries. Medicinal plants have been used traditionally throughout ages treat ailments due their availability safe nature. rich source phytochemicals possess benefits. As continues become prevalent, care practitioners considering plant-based medicines potential antidiabetic high potency fewer effects. To better understand mechanism action medicinal plants, active phytoconstituents being isolated investigated thoroughly. In review article, we focused on pharmacologically phytomolecules from presenting activity role they play treatment management diabetes. These natural compounds may represent good candidates for novel therapeutic approach and/or alternative therapies

Language: Английский

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Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8874 - 8874

Published: May 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Language: Английский

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Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 329 - 329

Published: March 1, 2024

In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, shorter duration of action pharmaceutical applications. However, those can be improved using nanotechnology create various drug delivery systems, including lipid-based nanoparticles, adjust the compounds’ physicochemical properties pharmacokinetic profile. Because enormous technical advancements made in fundamental sciences physical chemical manipulation individual atoms molecules, subject has experienced revolutionary growth. By fabricating certain functionalized particles, opens an innovative horizon research development for overcoming restrictions, traditional medication administration systems. Nanotechnology-driven are a impact clinical value current future uses. Lipid-based nanotechnologies were shown deliver range naturally occurring with decent entrapment potential successfully controlled release, increased intriguing activity. This review outlines such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, oridonin, fortified within either or synthetic system based on evaluation considerations.

Language: Английский

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Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(4), P. 1442 - 1458

Published: Dec. 14, 2021

Abstract This systematic review was designed to determine the clinical efficacy and safety of curcumin supplementation for pediatric patients based on trials in children. We systematically searched electronic databases including PubMed, EMBASE, Web Science, Scopus all studies that investigated administration population without any time frame limitation. Finally, we identified 16 this review. Clinical were assessed children with inflammatory immune disorders (including asthma, bowel disease (IBD), juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal dominant polycystic kidney (ADPKD), cystic fibrosis (CF), tetralogy Fallot (TOF), infectious diseases. Curcumin administered a wide range doses (45 mg–4,000 mg daily) durations (2–48 weeks). Overall, well tolerated improved severity However, more are needed clarify role among ADPKD, CF, TOF, Because substantial heterogeneity methodological quality, design, outcomes, dose, duration intake, formulations, study populations across studies, no quantitative analysis performed. Additional large‐scale, randomized, placebo‐controlled confirm results conducted studies.

Language: Английский

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The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile

Heliyon, Journal Year: 2022, Volume and Issue: 9(1), P. e12698 - e12698

Published: Dec. 31, 2022

Healthy diet is vital to cellular health. The human body succumbs numerous diseases which afflict severe economic and psychological burdens on the patient family. Oxidative stress a possible crucial regulator of various pathologies, including type 2 diabetes neurodegenerative diseases. It generates reactive oxygen species (ROS) that trigger dysregulation essential functions, ultimately affecting health homeostasis. However, lower levels ROS can be advantageous are implicated in variety signaling pathways. Due this dichotomy, terms oxidative "eustress," refers good event, "distress," hazardous, have developed. affects multiple pathways, leading compromised insulin secretion, resistance, β-cell dysfunction diabetes. also associated with increased mitochondrial neuroinflammation, aggravating conditions body, particularly age. Treatment includes drugs/therapies often dependence, side effects non-selectivity, toxicity, long run. imperative explore alternative medicines as an adjunct therapy, utilizing natural remedies/resources avoid all harms. Antioxidants components our fight disease by reducing or nullifying excess toxic free radicals produced under pathological conditions. In review, we focus antioxidant dietary foods such tea, coffee, wine, oils, honey role mechanism action these antioxidants alleviating disorders. We aim provide information about alternatives drug treatments used alone combined reduce intake encourage consumption ingredients at doses adequate promote combat pathologies while unwanted risks effects.

Language: Английский

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Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

Biocell, Journal Year: 2023, Volume and Issue: 47(11), P. 2547 - 2566

Published: Jan. 1, 2023

Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with multitude of factors linked to Inflammatory Bowel Disease (IBD). These encompass cytokines, oxidative stress-associated enzymes, modulation the intestinal microbiota. Notably, curcumin demonstrated therapeutic potential colitis, wherein it exerts negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, β-catenin. Moreover, inhibits expression pro-inflammatory enzymes co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating characteristic neutrophil infiltration observed IBD. Another facet curcumin's action involves its microbiota itself contributes beneficial biotrans formations curcumin, enhancing effectiveness IBD treatment. On front, ability induce and/or endoscopic remission without any reported toxic effects. Hence, warrants consideration an adjunctive therapy management. Subsequent investigations should concentrate meticulously evaluating impact these precise targets.

Language: Английский

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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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